Diborane(6)

RTECS #

HQ9275000

CAS #

19287-45-7
See: NMAM or OSHA Methods

Updated

December 2018

Molecular Weight

27.68

Molecular Formula

B₂H₆

Synonyms

Boroethane
Boron hydride
Diborane
Diborane (ACGIH:OSHA)
Diboron hexahydride

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
mutation in microorganisms	/Salmonella typhimurium	2000 ppm (+/-enzymatic activation step)	MUREAV 307,335,1994
mutation in microorganisms	/Salmonella typhimurium	5000 ppm (-enzymatic activation step)	MUREAV 307,335,1994

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/Dog	Lowest published lethal concentration: 125 ppm/2H	Brain and Coverings: Changes in surface EEG Lung, Thorax, or Respiration: Acute pulmonary edema Blood: Hemorrhage	AMIHAB 13,346,1956
inhalation/hamster	Lowest published lethal concentration: 50 ppm/8H	Lung, Thorax, or Respiration: Acute pulmonary edema	AMIHAB 21,519,1960
inhalation/mouse	lethal concentration (50 percent kill): 29 ppm/4H	Olfaction: Other olfaction effects Lung, Thorax, or Respiration: Acute pulmonary edema Lung, Thorax, or Respiration: Dyspnea	TXAPA9 4,215,1962
inhalation/rat	lethal concentration (50 percent kill): 40 ppm/4H		14KTAK -,693,1964
inhalation/rat	lethal concentration (50 percent kill): 60 mg/m³/4H		VCVN1* -,199,1988

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mouse	lowest published toxic concentration: 5 ppm/6H/4W- intermittent	Lung, Thorax, or Respiration: Changes in lung weight Blood: Changes in erythrocyte (RBC) count Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases	ARTODN 69,397,1995
inhalation/rat	lowest published toxic concentration: 100 ppb/6H/8W- intermittent	Lung, Thorax, or Respiration: Other changes Blood: Pigmented or nucleated red blood cells Nutritional and Gross Metabolic: Changes in: Na	TXAPA9 138,1977,1996

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 0.1 ppm	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		CTOXAO 6,497,1973
TOXICOLOGY REVIEW		RTOPDW 54,247,2009

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 0.1 ppm (0.1 mg/m³)	DTLVS* 3,72,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 0.1 ppm (0.11 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 0.1 ppm (0.1 mg/m³);KZW 0.2 ppm (0.2 mg/m³), 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 0.1 ppm (0.11 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 0.1 ppm (0.1 mg/m³), MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 0.1 ppm (0.11 mg/m³), short term exposure limit 0.3 ppm (0.34 mg/m³), NOV2011
Occupational Exposure Limit-FRANCE	VME 0.1 ppm (0.1 mg/m³), FEB2006
Occupational Exposure Limit-ICELAND	time-weighted average 0.1 ppm (0.1 mg/m³), NOV2011
Occupational Exposure Limit-JAPAN	Occupational Exposure Limit 0.01 ppm (0.012 mg/m³), MAY2012
Occupational Exposure Limit-KOREA	time-weighted average 0.1 ppm (0.1 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 0.1 ppm (0.1 mg/m³), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 0.1 ppm (0.11 mg/m³), JAN2002
Occupational Exposure Limit-PERU	time-weighted average 0.1 ppm (0.11 mg/m³), JUL2005
Occupational Exposure Limit-RUSSIA	short term exposure limit 0.1 mg/m³, JUN2003
Occupational Exposure Limit-SWITZERLAND	ceiling concentration 0.1 ppm (0.1 mg/m³), JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 0.1 mg/m³, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 0.1 ppm (0.1 mg/m³), JAN1993
Occupational Exposure Limit-TURKEY	time-weighted average 0.1 ppm (0.1 mg/m³), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 0.1 ppm (0.1 mg/m³)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 0.1 ppm (0.1 mg/m³)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 0.1 ppm (0.1 mg/m³)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 0.1 ppm (0.1 mg/m³)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIBORANE-air	10H time-weighted average 0.1 ppm	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 23650; Number of Industries 4; Total Number of Facilities 24; Number of Occupations 12; Total Number of Employees Exposed 4616; Total Number of Female Employees Exposed 1271
National Occupational Hazard Survey 1974	Hazard Code 23650; Number of Industries 2; Total Number of Facilities 24; Number of Occupations 3; Total Number of Employees Exposed 409

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NIOSH Analytical Method, 1994: Diborane, 6006
On EPA IRIS database

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health