2-Cyclohexen-1-one, 3,5,5-trimethyl-
RTECS #
GW7700000
CAS #
Updated
December 2017
Molecular Weight
138.23
Molecular Formula
C9H14O
Synonyms
1,1,3-Trimethyl-3-cyclohexene-5-one
3,3,5-Trimethyl-5-cyclohexen-1-one
3,5,5-Trimethyl-2-cyclohexen-1-on (German, Dutch)
3,5,5-Trimethyl-2-cyclohexen-1-one
3,5,5-Trimethyl-2-cyclohexene-1-one
3,5,5-Trimethylcyclohex-2-ene-1-one
3,5,5-Trimetil-2-cicloesen-1-one (Italian)
Isoacetophorone
Isoforon
Isoforone (Italian)
Isophoron
Isophorone
Isophorone (ACGIH:OSHA)
Izoforon (Polish)
NCI-C55618
3,3,5-Trimethyl-5-cyclohexen-1-one
3,5,5-Trimethyl-2-cyclohexen-1-on (German, Dutch)
3,5,5-Trimethyl-2-cyclohexen-1-one
3,5,5-Trimethyl-2-cyclohexene-1-one
3,5,5-Trimethylcyclohex-2-ene-1-one
3,5,5-Trimetil-2-cicloesen-1-one (Italian)
Isoacetophorone
Isoforon
Isoforone (Italian)
Isophoron
Isophorone
Isophorone (ACGIH:OSHA)
Izoforon (Polish)
NCI-C55618
Skin and Eye Irritation and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
eye /guinea pig | 840 ppm/4H | severe | JIHTAB 22,477,1940 |
eye /human | 25 ppm/15M | JIHTAB 28,262,1946 | |
eye /rabbit | 920 µg | severe | UCDS** 11/15/1971 |
eye /rabbit | 100 mg/24H | moderate | 85JCAE -,290,1986 |
skin /rabbit | 100 mg/24H | mild | JETOAS 5,31,1972 |
skin /rabbit | 0.5 mL/24H | moderate | VCVGK* -,460,1994 |
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
Cytogenetic Analysis | lung/hamster | 1250 mg/L | MUREAV 369,243,1996 |
mutation in mammalian somatic cells | lymphocyte/mouse | 400 mg/L | EMMUEG 12,85,1988 |
other mutation test systems | other cell types/human | 104 µmol/L | TIVIEQ 29,1425,2015 |
sister chromatid exchange | ovary/hamster | 1 gm/L | NTPTR* NTP-TR-291,1986 |
specific locus test | other cell types/mouse | 1500 mg/L/24H (-enzymatic activation step) | MUTAEX 14,23,1999 |
Unscheduled DNA Synthesis | liver/rat | 5 mmol/L | MUREAV 315,147,1994 |
Reproductive Effects Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/rat | 115 ppm/6H (6-15D pregnant) | Reproductive: Other effects on female | NTIS** OTS0546532 |
inhalation/mouse | 115 ppm/6H (6-15D pregnant) | Reproductive: Other effects on female | NTIS** OTS0546532 |
inhalation/rat | 115 ppm (6-15D pregnant) | Reproductive: Other effects on female | HPV275 -,-,2003 |
inhalation/mouse | 115 ppm (6-15D pregnant) | Reproductive: Other effects on female | HPV275 -,-,2003 |
Tumorigenic Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
oral/mouse | lowest published toxic dose: 258 gm/kg/2Y- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Kidney, Ureter, and Bladder: Kidney tumors | TXCYAC 39,207,1986 |
oral/mouse | lowest published toxic dose: 257500 mg/kg/103W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors | NTIS** PB86-181823/AS |
oral/mouse | lowest published toxic dose: 128750 mg/kg/103W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Blood: Lymphoma including Hodgkin's disease | NTIS** PB86-181823/AS |
oral/rat | lowest published toxic dose: 128750 mg/kg/103W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, and Bladder: Kidney tumors Tumorigenic: Increased incidence of tumors in susceptible strains | HPV275 -,-,2003 |
oral/rat | lowest published toxic dose: 128750 mg/kg/103W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Kidney, Ureter, and Bladder: Kidney tumors Reproductive: Other reproductive system tumors | NTIS** PB86-181823/AS |
oral/rat | lowest published toxic dose: 180 gm/kg/2Y- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, and Bladder: Bladder tumors | NTIS** OTS0571092 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/guinea pig | lowest published toxic concentration: 5000 mg/m3 | Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Cough | VCVGK* -,459,1994 |
inhalation/guinea pig | lowest published toxic concentration: 5000 mg/m3/150M | Behavioral: Alteration of classical conditioning | VCVGK* -,459,1994 |
inhalation/guinea pig | lowest published toxic concentration: 5000 mg/m3/6H | Lung, Thorax, or Respiration: Respiratory depression | VCVGK* -,459,1994 |
inhalation/guinea pig | lowest published toxic concentration: 5000 mg/m3/10H | Behavioral: General anesthetic Liver: Other changes Kidney, Ureter, and Bladder: Other changes | VCVGK* -,459,1994 |
inhalation/guinea pig | lethal concentration (50 percent kill): 4600 ppm/8H | 85JCAE -,290,1986 | |
inhalation/human | lowest published toxic concentration: 141 mg/m3/10M | Olfaction: Other olfaction effects Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Cough | VCVGK* -,459,1994 |
inhalation/human | lowest published toxic concentration: 1100 mg/m3/15M | Behavioral: Headache Gastrointestinal: Nausea or vomiting | VCVGK* -,459,1994 |
inhalation/human | lowest published toxic concentration: 25 ppm | Olfaction: Other olfaction effects Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Other changes | JIHTAB 28,262,1946 |
inhalation/mammal (species unspecified) | lethal concentration (50 percent kill): >7000 mg/m3/4H | FEREAC 70,21767,2005 | |
inhalation/mouse | lowest published toxic concentration: 4 ppm/6M | Lung, Thorax, or Respiration: Respiratory depression | TOLED5 9,137,1981 |
inhalation/mouse | Lethal concentration: >3500 mg/kg/6H | Lung, Thorax, or Respiration: Acute pulmonary edema | NTIS** OTS0535380 |
inhalation/rat | lethal concentration (50 percent kill): 7 gm/m3 | Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Dyspnea Skin and Appendages: Other: Hair | NTIS** OTS0572861 |
inhalation/rat | Lowest published lethal concentration: 10000 mg/m3/4H | Gastrointestinal: Gastritis Liver: Other changes | VCVGK* -,459,1994 |
inhalation/rat | lethal concentration (50 percent kill): 1281 ppm/4H | Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Dyspnea | HPV275 -,-,2003 |
intravenous/Dog | Lethal dose: >10 mg/kg | Behavioral: Convulsions or effect on seizure threshold Cardiac: Pulse rate decreased with fall in BP Lung, Thorax, or Respiration: Respiratory stimulation | NTIS** OTS0535380 |
oral/guinea pig | lethal dose (50 percent kill): 700 mg/kg | NTIS** OTS0535380 | |
oral/mammal (species unspecified) | lethal dose (50 percent kill): 1500 mg/kg | FEREAC 70,21767,2005 | |
oral/mouse | lethal dose (50 percent kill): 2690 mg/kg | TXAPA9 17,498,1970 | |
oral/rabbit | lethal dose (50 percent kill): 1420 mg/kg | NTIS** OTS0535380 | |
oral/rat | lethal dose (50 percent kill): 1870 mg/kg | UCDS** 11/15/1971 | |
oral/rat | lethal dose (50 percent kill): 3450 mg/kg | Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Acute pulmonary edema Gastrointestinal: Gastritis | HPV275 -,-,2003 |
skin/mammal (species unspecified) | lethal dose (50 percent kill): 1200 mg/kg | FEREAC 70,21767,2005 | |
skin/rabbit | lethal dose (50 percent kill): 1500 µL/kg | UCDS** 11/15/1971 | |
skin/rat | lethal dose (50 percent kill): 1390 mg/kg | NTIS** OTS0526403 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/guinea pig | lowest published toxic concentration: 500 ppm/8H/6W- intermittent | Lung, Thorax, or Respiration: Other changes Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | JIHTAB 24,46,1942 |
inhalation/guinea pig | lowest published toxic concentration: 500 ppm/8H/6W- intermittent | Liver: Other changes Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Blood: Changes in other cell count (unspecified) | NTIS** OTS0535380 |
inhalation/guinea pig | lowest published toxic concentration: 2800 mg/m3/8H/6W- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | VCVGK* -,459,1994 |
inhalation/guinea pig | lowest published toxic concentration: 280 mg/m3/8H/6W- intermittent | Kidney, Ureter, and Bladder: Other changes | VCVGK* -,459,1994 |
inhalation/human | lowest published toxic concentration: 5 ppm/30D- intermittent | Behavioral: Somnolence (general depressed activity) | VCVGK* -,460,1994 |
inhalation/rat | lowest published toxic concentration: 280 mg/m3/8H/6W- intermittent | Kidney, Ureter, and Bladder: Other changes | VCVGK* -,459,1994 |
inhalation/rat | lowest published toxic concentration: 2800 mg/m3/8H/6W- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | VCVGK* -,459,1994 |
inhalation/rat | lowest published toxic concentration: 500 ppm/8H/6W- intermittent | Lung, Thorax, or Respiration: Other changes Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | JIHTAB 24,46,1942 |
inhalation/rat | lowest published toxic concentration: 500 ppm/8H/6W- intermittent | Eye: Other eye effects Liver: Other changes Kidney, Ureter, and Bladder: Other changes in urine composition | NTIS** OTS0535380 |
inhalation/rat | lowest published toxic concentration: 208 mg/m3/6H/4W- intermittent | Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTIS** OTS0535380 |
oral/mouse | lowest published toxic dose: 24 gm/kg/16D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTPTR* NTP-TR-291,1986 |
oral/mouse | lowest published toxic dose: 65 gm/kg/13W- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTPTR* NTP-TR-291,1986 |
oral/rat | lowest published toxic dose: 24 gm/kg/16D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTPTR* NTP-TR-291,1986 |
oral/rat | lowest published toxic dose: 65 gm/kg/13W- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTPTR* NTP-TR-291,1986 |
oral/rat | lowest published toxic dose: 128750 mg/kg/103W- intermittent | Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Related to Chronic Data: Changes in ovarian weight | HPV275 -,-,2003 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-ceiling concentration 5 ppm | DTLVS* TLV/BEI,2013 |
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Confirmed animal carcinogen | DTLVS* TLV/BEI,2013 |
TOXICOLOGY REVIEW | MUREAV 543,201,2003 | |
TOXICOLOGY REVIEW | MUTAEX 14,5,1999 | |
TOXICOLOGY REVIEW | EMMUEG 39,69,2002 | |
TOXICOLOGY REVIEW | MUREAV 584,1,2005 | |
TOXICOLOGY REVIEW | FEREAC 71,45403,2006 | |
TOXICOLOGY REVIEW | FCTOD7 47,1287,2009 | |
TOXICOLOGY REVIEW | MUREAV 721,27,2011 | |
TOXICOLOGY REVIEW | MUREAV 763,36,2014 | |
TOXICOLOGY REVIEW | MUREAV 769,34,2014 | |
TOXICOLOGY REVIEW | MUREAV 802,1,2016 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 25 ppm (140 mg/m3) | DTLVS* 3,140,1971 |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
Occupational Exposure Limit-AUSTRALIA | ceiling concentration 5 ppm (28 mg/m3), JUL2008 | |
Occupational Exposure Limit-AUSTRIA | MAK-TMW 2 ppm (11 mg/m3);KZW 2 ppm (11 mg/m3), 2007 | |
Occupational Exposure Limit-BELGIUM | short term exposure limit 5 ppm (28 mg/m3), MAR2002 | |
Occupational Exposure Limit-DENMARK | ceiling concentration 5 ppm (25 mg/m3), carc, MAY2011 | |
Occupational Exposure Limit-FINLAND | time-weighted average 1 ppm (5.7 mg/m3), NOV2011 | |
Occupational Exposure Limit-FRANCE | VLE 5 ppm (25 mg/m3), C3 Carcinogen, FEB2006 | |
Occupational Exposure Limit-GERMANY | MAK 2 ppm (11 mg/m3), 2011 | |
Occupational Exposure Limit-ICELAND | short term exposure limit 5 ppm (30 mg/m3), NOV2011 | |
Occupational Exposure Limit-KOREA | ceiling concentration 5 ppm (25 mg/m3), 2006 | |
Occupational Exposure Limit-MEXICO | peak 5 ppm (25 mg/m3), 2004 | |
Occupational Exposure Limit-NEW ZEALAND | ceiling concentration 5 ppm (28 mg/m3), JAN2002 | |
Occupational Exposure Limit-PERU | short term exposure limit 5 ppm (28 mg/m3), JUL2005 | |
Occupational Exposure Limit-POLAND | MAC(time-weighted average) 5 mg/m3, MAC(C) 25 mg/m3, JAN1999 | |
Occupational Exposure Limit-RUSSIA | short term exposure limit 1 mg/m3, JUN2003 | |
Occupational Exposure Limit-SWEDEN | ceiling concentration 5 ppm (30 mg/m3), JUN2005 | |
Occupational Exposure Limit-SWITZERLAND | MAK-week 2 ppm (11 mg/m3), KZG-week 4 ppm (22 mg/m3), carc 3, JAN2011 | |
Occupational Exposure Limit-THE NETHERLANDS | MAC-C 25 mg/m3, 2003 | |
Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 25 ppm (140 mg/m3), JAN1993 | |
Occupational Exposure Limit-TURKEY | time-weighted average 25 ppm (149 mg/m3), JAN1993 | |
Occupational Exposure Limit-UNITED KINGDOM | short term exposure limit 5 ppm (29 mg/m3), OCT2007 | |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 25 ppm (140 mg/m3) | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 25 ppm (140 mg/m3) | CFRGBR 41,50-204.50,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 25 ppm (140 mg/m3) | CFRGBR 29,1910.1000,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 25 ppm (140 mg/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ISOPHORONE-air | 10H time-weighted average 4 ppm | NIOSH* DHHS #92-100,1992 |
National Occupational Exposure Survey 1983 | Hazard Code 40910; Number of Industries 43; Total Number of Facilities 3593; Number of Occupations 47; Total Number of Employees Exposed 47097; Total Number of Female Employees Exposed 10353 | |
National Occupational Hazard Survey 1974 | Hazard Code 40910; Number of Industries 44; Total Number of Facilities 2934; Number of Occupations 40; Total Number of Employees Exposed 26825 |
Status in Federal Agencies
Organization | Reference |
---|---|
ATSDR TOXICOLOGY PROFILE (NTIS** PB/90/180225/AS) | |
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE | FEREAC 47,26992,82 |
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
EPA TSCA Section 8(d) unpublished health/safety studies | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
NCI Carcinogenesis Studies (gavage);equivocal evidence:mouse,rat | |
NIOSH Analytical Method, 1994: Isophorone, 2508 | |
NTP Carcinogenesis Studies (gavage);some evidence:rat NTPTR* NTP-TR-291,1986 | |
On EPA IRIS database |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health