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4-Cyclohexene-1,2-dicarboximide, N-((1,1,2,2-tetrachloroethyl)thio)-

RTECS #
GW4900000
CAS #
2425-06-1
See: NMAM or OSHA Methods
Updated
June 2018
Molecular Weight
349.06
Molecular Formula
C10H9Cl4NO2S
Synonyms
1H-Isoindole-1,3(2H)-dione, 3a,4,7,7a-tetrahydro-2-((1,1,2,2-tetrachloroethyl)thio)- (9CI)
3a,4,7,7a-Tetrahydro-N-(1,1,2,2-tetrachloroethanesulphenyl)phthalimide
Alfloc 7020
Alfloc 7046
Arborseal
Captafol
Captafol (ACGIH)
CS5623
Difolatan
Difolatan 4F
Difolatan 80W
Difolatan BOW
Difosan
Folcid
Foltaf
Haipen 50
Merpafol
N-((1,1,2,2-Tetrachloroethyl)sulfenyl)-cis-4-cyclohexene-1,2-dicarboximide
N-(1,1,2,2-Tetrachloraethylthio)-cyclohex-4-en-1,4-diacarboximid (German)
N-(1,1,2,2-Tetrachloraethylthio)-tetrahydrophthalamid (German)
N-(1,1,2,2-Tetrachloroethylthio)-4-cyclohexene-1,2-dicarboximide
N-1,1,2,2-Tetrachloroethylmercapto-4-cyclohexene-1,2-carboximide
Nalco 7046
Ortho 5865
Proxel EF
Sanspor
Santar SM
Terrazol

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /human 0.05%/48HCODEDG 17,212,1987

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisembryo/human3400 µg/LSNSHBT (20),574,1980
Cytogenetic Analysislung/hamster10 µmol/LMUREAV 78,177,1980
DNA Damagekidney/rat1 µmol/L/20HTXCYAC 204,187,2004
DNA Damageoral/rat1250 mg/kgTXCYAC 204,187,2004
DNA Damagekidney/human0.5 µmol/L/20HTXCYAC 204,187,2004
DNA inhibitionother cell types/rat80 mg/LARTODN 45,101,1980
DNA inhibitionlymphocyte/human5 mg/LARTODN 45,101,1980
DNA repair/Bacillus subtilis100 ng/discMUREAV 40,19,1976
Dominant Lethal Testintraperitoneal/rat25 mg/kg/5DFCTXAV 10,353,1972
gene conversion and mitotic recombination/Aspergillus nidulans20 µg/plateMUREAV 46,395,1977
micronucleus testembryo/human3400 µg/LSNSHBT (20),574,1980
micronucleus testlung/hamster3400 µg/LSNSHBT (20),574,1980
micronucleus testkidney/human1 µmol/L/48HTXCYAC 204,187,2004
micronucleus testkidney/rat0.5 µmol/L/48HTXCYAC 204,187,2004
micronucleus testoral/rat1250 mg/kgTXCYAC 204,187,2004
morphological transformoral/rat7560 mg/kg/6WCRNGDP 9,387,1988
mutation in microorganisms/Aspergillus nidulans20 µg/plate (-enzymatic activation step)MUREAV 46,395,1977
mutation in microorganisms/Salmonella typhimurium100 µg/plate (+enzymatic activation step)EMCAE8 5,11,1985
mutation in microorganisms/Escherichia coli50 µg/plate (-enzymatic activation step)MUREAV 40,19,1976
mutation in microorganisms/Escherichia coli50 µg/plate (+enzymatic activation step)MUREAV 116,185,1983
other mutation test systems/Escherichia coli100 µg/LMUREAV 390,245,1997
sister chromatid exchangeembryo/human3400 µg/LSNSHBT (20),574,1980
sister chromatid exchangelung/hamster2 µmol/LMUREAV 78,177,1980

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat 500 mg/kg (5D male)Reproductive: Effects on embryo or fetus: Fetal deathFCTXAV 10,363,1972
oral/rabbit 975 mg/kg (6-18D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)TXAPA9 13,420,1968
oral/hamster 200 mg/kg (8D pregnant)Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TXAPA9 16,24,1970
oral/hamster 400 mg/kg (7D pregnant)Reproductive: Specific developmental abnormalities: Central nervous systemTXAPA9 16,24,1970
oral/rat 11 gm/kg (multigenerations)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)TXAPA9 13,420,1968
oral/rat 250 mg/kg (5D male)Reproductive: Effects on embryo or fetus: Fetal deathFCTXAV 10,363,1972

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 60480 mg/kg/96W- continuousTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Liver: Tumors
GANNA2 75,853,1984
oral/mouse toxic dose: 15120 mg/kg/96W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Cardiac: Tumors

Gastrointestinal: Tumors
JTSCDR 7,278,1982
oral/rat lowest published toxic dose: 65520 mg/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
JJCREP 81,1222,1990

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lowest published lethal dose: 3 mg/kgFCTXAV 13,55,1975
oral/rat lethal dose (50 percent kill): 2500 mg/kgWRPCA2 9,119,1970
skin/rabbit lethal dose (50 percent kill): 15400 mg/kgENTOX* -,407,2005
unreported route/rat lethal dose (50 percent kill): >6 gm/kgRREVAH 36,240,1971

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 45360 mg/kg/12W- continuousLiver: Other changes

Kidney, Ureter, and Bladder: Changes in bladder weight

Endocrine: Changes in spleen weight
JTEHD6 38,69,1993
oral/rat lowest published toxic dose: 39894.4 mg/kg/104W- continuousLiver: TumorsHBPTO* 1,814,2001
oral/rat lowest published toxic dose: 39894.4 mg/kg/104W- continuousKidney, Ureter, and Bladder: Kidney tumorsHBPTO* 1,814,2001

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.1 mg/m3 (skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 53,353,1991
International Agency for Research on Cancer (IARC)Cancer Review:Human No Available DataIMEMDT 53,353,1991
International Agency for Research on Cancer (IARC)Cancer Review:Group 2AIMEMDT 53,353,1991
TOXICOLOGY REVIEWMUREAV 32,3,1975
TOXICOLOGY REVIEWFCTOD7 44,1699,2006
TOXICOLOGY REVIEWENTOX* -,407,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWJTPAE7 19,1,2006
TOXICOLOGY REVIEWHUTOX* -,561,1996
TOXICOLOGY REVIEWFCTOD7 46,813,2008
TOXICOLOGY REVIEWMUREAV 769,34,2014
TOXICOLOGY REVIEWMUREAV 802,1,2016
TOXICOLOGY REVIEWMUREAV 823,45,2017

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,93,1998
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.1 mg/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 mg/m3, Skin, Carcinogen, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.1 mg/m3, skin, carc, MAY2011
Occupational Exposure Limit-FRANCEVME 0.1 mg/m3, Skin, C2 Carcinogen, FEB2006
Occupational Exposure Limit-HUNGARYceiling concentration 0.1 mg/m3, Carcinogen, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 0.1 mg/m3, carc, skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 0.1 mg/m3, skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.1 mg/m3 (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.1 mg/m3, skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.1 mg/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0.1 mg/m3, JUL2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 mg/m3, inhal, skin, JAN2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CAPTAFOL-air10H Carcinogen time-weighted average 0.1 mg/m3 (Sk)NIOSH* DHHS #95-121,1995
National Occupational Hazard Survey 1974Hazard Code M2985; Number of Industries 1; Total Number of Facilities 59; Number of Occupations 1; Total Number of Employees Exposed 117

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: Rodent dominant lethal; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: Aspergillus-aneuploidy; Host-mediated assay
EPA GENETOX PROGRAM 1988, Positive: Aspergillus-recombination; B subtilis rec assay
EPA GENETOX PROGRAM 1988, Positive: TRP reversion
EPA GENETOX PROGRAM 1988, Weakly Positive: TRP reversion
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 14th Report on Carcinogens,2016:Reasonably anticipated to be human carcinogen
On EPA IRIS database
Page last reviewed: November 16, 2018