Cyclohexene

RTECS #

GW2500000

CAS #

110-83-8
See: NMAM or OSHA Methods

Updated

September 2013

Molecular Weight

82.16

Molecular Formula

C₆H₁₀

Synonyms

1,2,3,4-Tetrahydrobenzene
Benzene, tetrahydro-
Benzenetetrahydride
Cyclohex-1-ene
Cyclohexene (ACGIH:OSHA)
Cykloheksen (Polish)
Hexanaphthylene
Tetrahydrobenzene

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mouse	lowest published toxic concentration: 30000 mg/m³	Behavioral: General anesthetic	VCVGH* -,95,1990
inhalation/mouse	lethal concentration (50 percent kill): 50000 mg/m³	Vascular: BP lowering not characterized in autonomic section Lung, Thorax, or Respiration: Respiratory obstruction	VCVGH* -,95,1990
inhalation/rat	Lethal concentration: >6370 ppm/4H	Behavioral: Tremor Behavioral: Ataxia Lung, Thorax, or Respiration: Other changes	NTIS** OTS0555329
inhalation/rat	Lethal concentration: >6370 ppm/4H	Behavioral: Tremor Behavioral: Ataxia	HPV158 -,-,2007
oral/mouse	lethal dose (50 percent kill): >3200 µL/kg	Behavioral: Altered sleep time (including change in righting reflex) Behavioral: Somnolence (general depressed activity) Behavioral: Ataxia	NTIS** OTS0546026
oral/mouse	lethal dose (50 percent kill): 2300 mg/kg		VCVGH* -,95,1990
oral/rat	lethal dose (50 percent kill): 1300 mg/kg		VCVGH* -,95,1990
oral/rat	lethal dose (16 percent kill): 920 mg/kg		VCVGH* -,95,1990
oral/rat	lethal dose (84 percent kill): 3800 mg/kg		VCVGH* -,95,1990
oral/rat	lowest published toxic dose: 400 mg/kg	Nutritional and Gross Metabolic: Weight loss or decreased weight gain Nutritional and Gross Metabolic: Changes in: Metabolic acidosis Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	VCVGH* -,95,1990
oral/rat	lowest published lethal dose: 2000 mg/kg	Behavioral: Tremor Lung, Thorax, or Respiration: Acute pulmonary edema Gastrointestinal: Changes in structure or function of salivary glands	HPV158 -,-,2007
oral/rat	lethal dose (50 percent kill): 2400 µL/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Tremor Behavioral: Ataxia	NTIS** OTS0546026
skin/guinea pig	lethal dose (50 percent kill): >20 mL/kg		HPV158 -,-,2007
unreported route/rat	lethal dose (50 percent kill): 2 gm/kg		GTPZAB 29(12),53,1985

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	lowest published toxic concentration: 600 ppm/6H/26W- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases	TXAPA9 37,155,1976
oral/rat	lowest published toxic dose: 7200 mg/kg/48D- intermittent	Gastrointestinal: Changes in structure or function of salivary glands	HPV158 -,-,2007
oral/rat	lowest published toxic dose: 24000 mg/kg/48D- intermittent	Gastrointestinal: Changes in structure or function of salivary glands Kidney, Ureter, and Bladder: Changes in kidney weight	HPV158 -,-,2007
oral/rat	lowest published toxic dose: 6300 mg/kg/42D- intermittent	Gastrointestinal: Changes in structure or function of salivary glands	HPV158 -,-,2007

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 300 ppm	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		ENTOX* -,707,2005

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 300 ppm (1015 mg/m³)	DTLVS* 3,66,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 300 ppm (1010 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 300 ppm (1015 mg/m³);KZW 1200 ppm (4060 mg/m³), 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 300 ppm (1025 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 300 ppm (1015 mg/m³), MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 300 ppm (1000 mg/m³), short term exposure limit 380 ppm (1300 mg/m³), NOV2011
Occupational Exposure Limit-FRANCE	VME 300 ppm (1015 mg/m³), FEB2006
Occupational Exposure Limit-ICELAND	time-weighted average 300 ppm (1015 mg/m³), NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 300 ppm (1050 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 300 ppm (1015 mg/m³), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 300 ppm (1.01 mg/m³), JAN2002
Occupational Exposure Limit-PERU	time-weighted average 300 ppm (1008 mg/m³), JUL2005
Occupational Exposure Limit-POLAND	MAC(time-weighted average) 300 mg/m³, MAC(short term exposure limit) 900 mg/m³, JAN1999
Occupational Exposure Limit-RUSSIA	short term exposure limit 50 mg/m³, JUN2003
Occupational Exposure Limit-SWITZERLAND	MAK-week 300 ppm (1015 mg/m³), JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 1015 mg/m³, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 300 ppm (1015 mg/m³), JAN1993
Occupational Exposure Limit-TURKEY	time-weighted average 300 ppm (1050 mg/m³), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 300 ppm (1015 mg/m³)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 300 ppm (1015 mg/m³)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 300 ppm (1015 mg/m³)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 300 ppm (1015 mg/m³)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CYCLOHEXENE-air	10H time-weighted average 300 ppm	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 21705; Number of Industries 1; Total Number of Facilities 40; Number of Occupations 1; Total Number of Employees Exposed 517; Total Number of Female Employees Exposed 239
National Occupational Hazard Survey 1974	Hazard Code 21705; Number of Industries 1; Total Number of Facilities 16; Number of Occupations 7; Total Number of Employees Exposed 529

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Hydrocarbons, BP 36-126 degree C, 1500

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health