o-Cresol, 4,6-dinitro-

RTECS #

GO9625000

CAS #

534-52-1
See: NMAM or OSHA Methods

Updated

September 2018

Molecular Weight

198.15

Molecular Formula

C₇H₆N₂O₅

Synonyms

2,4-Dinitro-6-methylphenol
2,4-Dinitro-o-cresol
2-Methyl-4,6-dinitrophenol
3,5-Dinitro-2-hydroxytoluene
4,6-Dinitrocresol
4,6-Dinitrokresol (Dutch)
4,6-Dinitro-o-cresol
4,6-Dinitro-o-cresolo (Italian)
4,6-Dinitro-o-kresol (Czech)
Antinonin
Antinonnin
Arborol
C.I. 10310
Capsine
Chemsect DNOC
Degrassan
Dekrysil
Detal
Detol
Dinitrocresol
Dinitrodendtroxal
Dinitrol
Dinitromethyl cyclohexyltrienol
Dinitro-o-cresol
Dinitro-o-cresol (ACGIH:OSHA)
Dinoc
Dinurania
Ditrosol
DNOC
DNOK (Czech)
Dwunitro-O-krezol (Polish)
Effusan
Effusan 3436
Elgetol
Elgetol 30
Elipol
ENT 154
Extrar
Hedolit
Hedolite
K III
K IV
Kresonite-E
Krezotol 50
LE dinitrocresol-4,6 (French)
Lipan
Neudorff DN 50
Nitrador
Nitrofan
Oranz viktoria (Czech)
Phenol, 2-methyl-4,6-dinitro- (9CI)
Prokarbol
Rafex
Rafex 35
Raphatox
RCRA waste number P047
Sandolin
Sandolin A
Selinon
Sinox
Winterwash
Zahlreiche bezeichnungen (German)

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /rabbit	20 mg/24H	moderate	85JCAE -,678,1986
skin /rabbit	105 mg/9D- intermittent	mild	JIHTAB 30,10,1948

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Cytogenetic Analysis	oral/rat	15 mg/kg	MUREAV 321,219,1994
DNA repair	/Other microorganisms	10 mg/plate	BIZNAT 95,463,1976
mutation in microorganisms	/Salmonella typhimurium	100 µg/plate (+enzymatic activation step)	STBIBN 117,99,1987
mutation in microorganisms	/Salmonella typhimurium	1 µmol/plate (-enzymatic activation step)	AIDZAC 10,305,1982
mutation in microorganisms	/Salmonella typhimurium	100 µg/plate/48H (-enzymatic activation step)	EMMUEG 47,95,2006
mutation in microorganisms	/Salmonella typhimurium	100 µg/plate/48H	EMMUEG 47,95,2006
sex chromosome loss and nondisjunction	oral/Drosophila melanogaster	250 µmol/L	ATSUDG 4,59,1980

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
oral/rat	75 mg/kg (5D male)	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)	REPTED 22,501,2006
oral/rat	50 mg/kg (5D male)	Related to Chronic Data: Changes in testicular weight	REPTED 22,501,2006

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Rat, endocrine tumor	Inhibitor Concentration Low: 10 µmol/L	Nutritional and Gross Metabolic: Changes in: Ca	TOLED5 252,62,2016
In Vitro/Rat, endocrine tumor	Inhibitor Concentration Low: 100 µmol/L/24H	In Vitro Toxicity Studies: Cell metabolic activity: Alamar Blue assay etc. In Vitro Toxicity Studies: Apoptosis in vitro	TOLED5 252,62,2016
In Vitro/Rat, endocrine tumor	Inhibitor Concentration Low: 10 µmol/L/24H	In Vitro Toxicity Studies: Cell Viability (cell death), unspecified assay	TOLED5 252,62,2016
In Vitro/Rat, endocrine tumor	Inhibitor Concentration Low: 1 µmol/L/48H	In Vitro Toxicity Studies: Other assays	TOLED5 252,62,2016
inhalation/cat	Lowest published lethal concentration: 40 mg/m³/4H	Behavioral: Somnolence (general depressed activity) Behavioral: Muscle weakness Lung, Thorax, or Respiration: Dyspnea	HYSAAV 30(1-3),197,1965
inhalation/human	lowest published toxic concentration: 1 mg/m³	Brain and Coverings: Recordings from specific areas of CNS Cardiac: Other changes Gastrointestinal: Other changes	HYSAAV 30(1-3),197,1965
inhalation/mammal (species unspecified)	lethal concentration (30 percent kill): 100 mg/m³		GTPZAB 9(4),56,1965
intraperitoneal/guinea pig	lethal dose (50 percent kill): 22500 µg/kg		JPPMAB 6,619,1954
intraperitoneal/mouse	lethal dose (50 percent kill): 19 mg/kg		BCPCA6 18,1389,1969
intraperitoneal/rabbit	lethal dose (50 percent kill): 23500 µg/kg		JPPMAB 6,619,1954
intraperitoneal/rat	lowest published lethal dose: 28 mg/kg		TXAPA9 1,156,1959
intravenous/Dog	lowest published lethal dose: 15 mg/kg		AIPTAK 50,20,1935
intravenous/pigeon	lowest published lethal dose: 7 mg/kg	Gastrointestinal: Nausea or vomiting Lung, Thorax, or Respiration: Dyspnea	AIPTAK 50,20,1935
oral/cat	lethal dose (50 percent kill): 50 mg/kg		GTPZAB 9(4),56,1965
oral/domestic animal	lethal dose (50 percent kill): 100 mg/kg		85DPAN -,-,1971/1976
oral/duck	lethal dose (50 percent kill): 383000 mg/kg		HBPTO* 2,1229,2001
oral/guinea pig	lethal dose (50 percent kill): 24600 µg/kg		GISAAA 41(6),12,1976
oral/man	lowest published toxic dose: 7500 µg/kg/7D	Behavioral: Somnolence (general depressed activity) Behavioral: Headache	CMEP** -,1,1956
oral/mouse	lethal dose (50 percent kill): 21 mg/kg		AMRL** TR-72-62,1972
oral/quail	lethal dose (50 percent kill): 1040000 mg/kg		HBPTO* 2,1229,2001
oral/rabbit	lethal dose (50 percent kill): 24600 µg/kg		GISAAA 41(6),12,1976
oral/rat	lethal dose (50 percent kill): 7 mg/kg		DEVEAA 26,69,1972
oral/rat	lethal dose (50 percent kill): 40 mg/kg	Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)	FATOAO 47,90,1984
skin/child	lowest published lethal dose: 500 mg/kg	Behavioral: Coma Behavioral: Headache Gastrointestinal: Nausea or vomiting	SMEZA5 17(1),52,1974
skin/guinea pig	lowest published lethal dose: 500 mg/kg		JIHTAB 30,10,1948
skin/rabbit	lethal dose (50 percent kill): 1 gm/kg		GTPZAB 9(4),56,1965
skin/rat	lethal dose (50 percent kill): 200 mg/kg		WRPCA2 9,119,1970
subcutaneous/rat	lethal dose (50 percent kill): 25600 µg/kg		JPPMAB 4,1062,1952
unreported route/man	lowest published lethal dose: 29 mg/kg		85DCAI 2,73,1970
unreported route/mouse	lethal dose (50 percent kill): 40 mg/kg		TGANAK 16(1),45,1982
unreported route/rat	lethal dose (50 percent kill): 85 mg/kg		GTPZAB 26(6),21,1982

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/cat	lowest published toxic concentration: 2 mg/m³/4H/4W- intermittent	Endocrine: Hyperglycemia Blood: Changes in leukocyte (WBC) count Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	GISAAA 30(2),34,1965
intraperitoneal/guinea pig	lowest published toxic dose: 780 mg/kg/30D- intermittent	Liver: Other changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases	AMASA4 34,87,1977
oral/rat	lowest published toxic dose: 45500 µg/kg/26W- intermittent	Liver: Other changes Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases	GISAAA 41(6),12,1976

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 0.2 mg/m³ (skin)	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		DTTIAF 80,485,1973
TOXICOLOGY REVIEW		FNSCA6 2,67,1973
TOXICOLOGY REVIEW		MUTAEX 21,93,2006
TOXICOLOGY REVIEW		REPTED 26,185,2008
TOXICOLOGY REVIEW		NBREV* 5,1,1981

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	Cancelled	RBREV* -,175,1998
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 0.2 mg/m³ (skin)	DTLVS* 3,93,1971
Occupational Exposure Limit-AUSTRALIA	time-weighted average 0.2 mg/m³, JUL2008
Occupational Exposure Limit-BELGIUM	time-weighted average 0.2 mg/m³, Skin, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 0.2 mg/m³, skin, MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 0.2 mg/m³, short term exposure limit 0.6 mg/m³, skin, NOV2011
Occupational Exposure Limit-FRANCE	VME 0.2 mg/m³, Skin, FEB2006
Occupational Exposure Limit-HUNGARY	time-weighted average 0.2 mg/m³, short term exposure limit 0.8 mg/m³, Skin, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 0.2 mg/m³, skin, NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 0.2 mg/m³, skin, 2006
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 0.2 mg/m³, skin, JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 25 ppm (125 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 0,2 mg/m³, JUL2005
Occupational Exposure Limit-RUSSIA	time-weighted average 0.05 mg/m³, short term exposure limit 0.2 mg/m³, JUN2003
Occupational Exposure Limit-SWITZERLAND	MAK-week 0.2 mg/m³, KZG-week 0.4 mg/m³, inhal, skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 0.2 mg/m³, Skin, 2003
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 0.2 mg/m³ (skin)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 0.2 mg/m³ (skin)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 0.2 mg/m³ (skin)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 0.2 mg/m³ (skin)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DINITRO-o-CRESOL-air	10H time-weighted average 0.2 mg/m³ (Sk)	NIOSH* DHHS #92-100,1992

Status in Federal Agencies

Organization	Reference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/264321)
EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health