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p-Cresol, 2,6-di-tert-butyl-

RTECS #
GO7875000
CAS #
128-37-0; 58500-82-6
See: NMAM or OSHA Methods
Updated
March 2019
Molecular Weight
220.39
Molecular Formula
C15H24O
Synonyms
2,6-Bis(1,1-dimethylethyl)-4-methylphenol
2,6-Di-terc.butyl-p-kresol (Czech)
2,6-Di-tert-butyl-1-hydroxy-4-methylbenzene
2,6-Di-tert-butyl-4-methylphenol
2,6-Di-tert-butyl-p-cresol
2,6-Di-tert-butyl-p-cresol (ACGIH)
2,6-Di-tert-butyl-p-methylphenol
3,5-Di-tert-butyl-4-hydroxytoluene
4-Hydroxy-3,5-di-tert-butyltoluene
4-Methyl-2,6-di-terc. butylfenol (Czech)
4-Methyl-2,6-di-tert-butylphenol
Advastab 401
Agidol
Agidol 1
Alkofen BP
Antioxidant 29
Antioxidant 30
Antioxidant 4
Antioxidant 4K
Antioxidant DBPC
Antioxidant KB
Antrancine 8
AO 29
AO 4K
BHT
BHT (food grade)
BUKS
Butylated hydroxytoluene
Butylhydroxytoluene
Butylohydroksytoluenu (Polish)
CAO 1
CAO 3
Catalin cao-3
Chemanox 11
Dalpac
DBMP
DBPC
DBPC (technical grade)
Deenax
Dibunol
Dibutylated hydroxytoluene
Impruvol
Ionol
Ionol (antioxidant)
Ionol 1
Ionol CP
Ionole
Kerabit
Methyldi-tert-butylphenol
NCI-C03598
Nocrac 200
Nonox TBC
P 21
Parabar 441
Paranox 441
Phenol, 2,6-bis(1,1-dimethylethyl)-4-methyl- (9CI)
Stavox
Sumilizer BHT
Sustane BHT
Swanox BHT
Tenamene 3
Tenox BHT
Topanol
Topanol O
Topanol OC
Toxolan P
Vanlube PC
Vanlube PCX
Vianol
Vulkanox KB

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg/24H moderate85JCAE -,229,1986
skin /human 500 mg/48H mildAMIHBC 5,311,1952
skin /rabbit 500 mg/48H moderateAMIHBC 5,311,1952

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisovary/hamster100 µg/LMUREAV 345,73,1995
DNA Damageoral/mouse100 mg/kgMUREAV 519,103,2002
DNA Damageoral/rat1400 mg/kg/2DHPV260 -,-,2001
DNA Damageoral/rat1400 mg/kgFCTOD7 25,603,1987
DNA inhibitionHeLa cell/human500 µmol/LCRNGDP 13,2389,1992
DNA inhibitionlymphocyte/human20 µmol/LBBRCA9 80,963,1978
DNA inhibitionintraperitoneal/mouse250 mg/kgCBINA8 19,279,1977
Dominant Lethal Testoral/mouse12 gm/kg/10W-continuousNTIS** PB278-026
Dominant Lethal Testoral/rat5460 mg/kg/10W-continuousENMUDM 8,357,1986
mutation in mammalian somatic cellslymphocyte/mouse6 mg/LEMMUEG 11,91,1988
mutation in microorganismslymphocyte/mouse6 mg/L (+enzymatic activation step)EMMUEG 11,91,1988
other mutation test systemsoral/mouse500 mg/kgMUREAV 343,157,1995
specific locus testother cell types/mouse45 µmol/LMUREAV 608,29,2006
sperm morphologyintraperitoneal/mouse350 mg/kg/5D- intermittentCMMUAO 5,257,1978
Unscheduled DNA Synthesisoral/rat16800 mg/kg/4W-continuousTXAPA9 99,37,1989
Unscheduled DNA Synthesisliver/rat100 pmol/LCRNGDP 5,1547,1984
Unscheduled DNA Synthesisintraperitoneal/rat1200 mg/kg/3D-continuousDANKAS 287,371,1986

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 6 gm/kg (13W male/13W pre-3W after birth)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)FCTOD7 24,1,1986
oral/rat 18 gm/kg (2W male/2W pre-3W after birth)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Behavioral
FCTXAV 19,153,1981
oral/rat 9 gm/kg (2W male/2W pre-3W after birth)Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)FCTXAV 19,153,1981
oral/rat 35 gm/kg (10W male)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)ENMUDM 8,357,1986
oral/mouse 43800 mg/kg (52D prior to copulation/1-21D pregnant)Reproductive: Maternal effects: Parturition

Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
FCTXAV 3,371,1965
oral/mouse 12600 mg/kg (1-21D pregnant)Reproductive: Effects on newborn: BehavioralFEPRA7 31,596,1972
oral/mouse 1200 mg/kg (9D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemTRENAF 28(2),45,1977
oral/rat 28000 mg/kg (multigeneration)Reproductive: Other effects on female

Reproductive: Effects on newborn: Biochemical and metabolic
HPV260 -,-,2001
oral/rat 3300 mg/kg (7-17D pregnant)Reproductive: Effects on newborn: PhysicalHPV260 -,-,2001
oral/mouse 1200 mg/kg (9D pregnant)Reproductive: Other effects on femaleHPV260 -,-,2001

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 435 mg/kg/69W- continuousTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Gastrointestinal: Tumors
FCTXAV 12,367,1974
oral/mouse toxic dose: 1423 mg/kg/43W- continuousTumorigenic: Neoplastic by RTECS criteria

Liver: Tumors
TXCYAC 38,151,1986
oral/mouse lowest published toxic dose: 1200 mg/kg/3W- intermittentTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Tumor types after systemic administration not seen spontaneously
CALEDQ 145,101,1999
oral/rat lowest published toxic dose: 134 gm/kg/32W- continuousTumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors

Tumorigenic: Cells (cultured) transformed
CRNGDP 4,895,1983
oral/rat toxic dose: 247 gm/kgTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
FCTOD7 24,1121,1986
oral/rat toxic dose: 963 gm/kgTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors
FCTOD7 24,1071,1986
oral/rat toxic dose: 247 gm/kg/3Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Reproductive: Tumorigenic effects: Transplacental tumorigenesis

Liver: Tumors
FCTOD7 24,1,1986
oral/rat toxic dose: 247 gm/kg/3Y- continuousTumorigenic: Neoplastic by RTECS criteria

Reproductive: Tumorigenic effects: Ovarian tumors
FCTOD7 24,1,1986

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, leukemia cells Inhibitor Concentration Low: 10 mg/LBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductasesJOETD7 146,456,2013
In Vitro/Human, leukemia cells Inhibitor Concentration Low: 2.5 mg/L/16HBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationJOETD7 146,456,2013
In Vitro/Human, lung tumor Inhibitor Concentration (50 percent kill): 0.15 mmol/L/24HIn Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.TIVIEQ 1,85,1987
In Vitro/Rat, lung Inhibitor Concentration (50 percent kill): 4.04 mmol/L/24HIn Vitro Toxicity Studies: Cell countingTIVIEQ 18,79,2004
intraperitoneal/mouse lowest published toxic dose: 150 mg/kgLung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes

Biochemical: Metabolism (intermediary): Other proteins
CRTOEC 21,1631,2008
intraperitoneal/mouse lethal dose (50 percent kill): 138 mg/kgLung, Thorax, or Respiration: Acute pulmonary edema

Blood: Hemorrhage
IJTOFN 21,19,2002
intraperitoneal/mouse lethal dose (50 percent kill): 138 mg/kgENTOX* -,365,2005
intraperitoneal/mouse lethal dose (50 percent kill): 138 mg/kgLung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Lung, Thorax, or Respiration: Other changes

Blood: Hemorrhage
TXAPA9 61,475,1981
intraperitoneal/mouse lowest published toxic dose: 100 mg/kgLung, Thorax, or Respiration: Fibrosis (interstitial)

Lung, Thorax, or Respiration: Changes in lung weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,212,1994
intraperitoneal/rat lethal dose (50 percent kill): 8 gm/kgIJTOFN 21,19,2002
intraperitoneal/rat lowest published toxic dose: 10 mg/kgLiver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport
FATOAO 55,34,1992
intraperitoneal/rat lowest published toxic dose: 1 mg/kgImmunological Including Allergic: Other immediate (humoral): uticaria, allergic rhinitis, serum sickness (multiple organ involvement)TXAPA9 223,164,2007
intravenous/mouse lethal dose (50 percent kill): 180 mg/kgBehavioral: SleepJMCMAR 23,1350,1980
oral/cat lowest published lethal dose: 940 mg/kgGastrointestinal: Hypermotility, diarrhea

Behavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression
AMIHAB 11,93,1955
oral/cat lowest published lethal dose: 940 mg/kgVCVGK* -,212,1994
oral/guinea pig lethal dose (50 percent kill): 10700 mg/kgGastrointestinal: Hypermotility, diarrhea

Behavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression
AMIHAB 11,93,1955
oral/guinea pig lethal dose (50 percent kill): 10700 mg/kgENTOX* -,365,2005
oral/mouse lethal dose (50 percent kill): 1040 mg/kgENTOX* -,365,2005
oral/mouse lethal dose (50 percent kill): 650 mg/kgBehavioral: Tremor

Behavioral: Ataxia

Lung, Thorax, or Respiration: Other changes
IJTOFN 21,19,2002
oral/mouse lowest published toxic dose: 50 mg/kgBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationEKFAE9 62,56,1999
oral/mouse lethal dose (50 percent kill): 650 mg/kgBehavioral: Tremor

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion
SRTCAC 36(1-4),10,1989
oral/rabbit lowest published lethal dose: 2100 mg/kgGastrointestinal: Hypermotility, diarrhea

Behavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression
AMIHAB 11,93,1955
oral/rabbit lethal dose (50 percent kill): 2100 mg/kgVCVGK* -,212,1994
oral/rabbit lowest published lethal dose: 2000 mg/kgVCVGK* -,212,1994
oral/rat lowest published toxic dose: 25 mg/kgBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
EKFAE9 62,56,1999
oral/rat lethal dose (50 percent kill): 890 mg/kgENTOX* -,365,2005
oral/woman lowest published toxic dose: 80 mg/kgBehavioral: Coma

Gastrointestinal: Gastritis

Gastrointestinal: Nausea or vomiting
NEJMAG 314,648,1986
rectal/mouse lowest published toxic dose: 50 mg/kgBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationEKFAE9 62,56,1999
rectal/rat lowest published toxic dose: 25 mg/kgBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
EKFAE9 62,56,1999
skin/rat lethal dose (50 percent kill): >2000 mg/kgHPV260 -,-,2001
subcutaneous/mouse lethal dose (50 percent kill): 650 mg/kgENTOX* -,365,2005

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/guinea pig lowest published toxic dose: 570 mg/kg/3D- intermittentBlood: Change in clotting factorsVCVGK* -,212,1994
intraperitoneal/hamster lowest published toxic dose: 1140 mg/kg/3D- intermittentBrain and Coverings: Changes in circulation

Behavioral: Tremor
VCVGK* -,212,1994
intraperitoneal/mouse lowest published toxic dose: 1750 mg/kg/1W- intermittentGastrointestinal: Tumors

Liver: Tumors

Kidney, Ureter, and Bladder: Bladder tumors
VCVGK* -,213,1994
intraperitoneal/mouse lowest published toxic dose: 600 mg/kg/4W- intermittentLung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes

Biochemical: Metabolism (intermediary): Other proteins
CRTOEC 21,1631,2008
intraperitoneal/mouse lowest published toxic dose: 750 mg/kg/3W- intermittentLung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXCYAC 169,1,2001
intraperitoneal/mouse lowest published toxic dose: 750 mg/kg/3W- intermittentBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationTXCYAC 169,1,2001
intraperitoneal/mouse lowest published toxic dose: 735 mg/kg/4W- intermittentLung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
JNCIEQ 97,1778,2005
intraperitoneal/rabbit lowest published toxic dose: 480 mg/kg/4D- intermittentCardiac: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
FATOAO 55,19,1992
oral/hamster lowest published toxic dose: 1596 mg/kg/14D- continuousLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
FCTOD7 34,595,1996
oral/monkey lowest published toxic dose: 14 gm/kg/4W- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: PhosphatasesFCTXAV 10,769,1972
oral/mouse lowest published toxic dose: 13500 mg/kg/18D- intermittentLiver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
FCTXAV 3,417,1965
oral/mouse lowest published toxic dose: 48600 mg/kg/30D- continuousLung, Thorax, or Respiration: Changes in lung weight

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
FCTOD7 30,89,1992
oral/mouse lowest published toxic dose: 10.08 mg/kg/1W- continuousBrain and Coverings: Changes in circulation

Blood: Hemorrhage

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,212,1994
oral/mouse lowest published toxic dose: 2000 mg/kg/4D- intermittentLiver: Multiple effects

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,212,1994
oral/rat lowest published toxic dose: 6.3 mg/kg/1W- continuousBrain and Coverings: Changes in circulation

Blood: Hemorrhage

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,212,1994
oral/rat lowest published toxic dose: 547.5 mg/kg/2Y- continuousBrain and Coverings: Changes in brain weight

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,213,1994
oral/rat lowest published toxic dose: 1200 mg/kg/3D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferasesFATOAO 50,81,1987
oral/rat lowest published toxic dose: 840 mg/kg/14D- intermittentCardiac: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
EKFAE9 56,47,1993
oral/rat lowest published toxic dose: 5185 mg/kg/4W- continuousLiver: Other changes

Liver: Changes in liver weight
TOLED5 87,103,1996
oral/rat lowest published toxic dose: 109 gm/kg/2Y- continuousBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count
FCTXAV 19,147,1981
oral/rat lowest published toxic dose: 27 gm/kg/90D- continuousLiver: Changes in liver weight

Endocrine: Evidence of thyroid hyperfunction

Endocrine: Changes in thyroid weight
TOLED5 10,239,1982
oral/rat lowest published toxic dose: 37800 mg/kg/6W- continuousLiver: Changes in liver weight

Endocrine: Changes in adrenal weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
AJEBAK 39,353,1961
oral/rat lowest published toxic dose: 5600 mg/kg/16W- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Other changes in urine composition
FCTXAV 3,433,1965
oral/rat lowest published toxic dose: 275 mg/kg/26W- continuousLiver: Changes in liver weight

Skin and Appendages: Other: Hair

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
AJEBAK 37,533,1959
oral/rat lowest published toxic dose: 112 gm/kg/80W- continuousLiver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Metabolism (intermediary): Other proteins
TXCYAC 7,289,1977
oral/rat lowest published toxic dose: 5040 mg/kg/7D- continuousLiver: Changes in liver weight

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
APTOA6 49,14,1981
oral/rat lowest published toxic dose: 350 mg/kg/7D- intermittentGastrointestinal: Other changes

Liver: Other changes
FATOAO 47,87,1984
oral/rat lowest published toxic dose: 350 mg/kg/7D- intermittentGastrointestinal: Other changesFATOAO 47,87,1984
oral/rat lowest published toxic dose: 500 mg/kg/5D- intermittentGastrointestinal: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
EKFAE9 61,21,1998
oral/rat lowest published toxic dose: 39.7 mg/kg/3D- intermittentBlood: Change in clotting factorsEKFAE9 62,38,1999
oral/rat lowest published toxic dose: 6300 mg/kg/6W- continuousLiver: Tumors

Tumorigenic: Protects against induction of experimental tumors

Tumorigenic: Active as anti-cancer agent
CALEDQ 143,173,1999
oral/rat lowest published toxic dose: 2.625 mg/kg/1W- continuousLiver: Other changes

Blood: Change in clotting factors

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
VCVGK* -,212,1994
oral/rat lowest published toxic dose: 2000 mg/kg/4D- intermittentLiver: Multiple effects

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,212,1994
oral/rat lowest published toxic dose: 4200 mg/kg/14D- continuousLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
BIJOAK 300,117,1994
oral/rat lowest published toxic dose: 778.4 mg/kg/28D- continuousLiver: Other changesFCTOD7 46,2616,2008
oral/rat lowest published toxic dose: 2458.4 mg/kg/28D- continuousLiver: Other changes

Liver: Changes in liver weight
FCTOD7 46,2616,2008
oral/rat lowest published toxic dose: 4673.2 mg/kg/28D- continuousLiver: Other changes

Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
FCTOD7 46,2616,2008
oral/rat lowest published toxic dose: 8999.2 mg/kg/28D- continuousLiver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
FCTOD7 46,2616,2008
oral/rat lowest published toxic dose: 32446.4 mg/kg/28D- continuousLiver: Other changes

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FCTOD7 46,2616,2008
oral/rat lowest published toxic dose: 239400 mg/kg/76W- intermittentLiver: Other changes

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV260 -,-,2001
oral/rat lowest published toxic dose: 119700 mg/kg/76W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainHPV260 -,-,2001
skin/mouse lowest published toxic dose: 5 gm/kg/4W- intermittentLung, Thorax, or Respiration: Changes in lung weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOLED5 34,99,1986

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 2 mg/m3 (inhal, vapor)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 40,161,1986
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 40,161,1986
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMSUDL 7,56,1987
TOXICOLOGY REVIEWFEPRA7 35,89,1976
TOXICOLOGY REVIEWIJTOFN 21,19,2002
TOXICOLOGY REVIEWENTOX* -,365,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 659,15,2008
TOXICOLOGY REVIEWHUTOX* -,259,1996
TOXICOLOGY REVIEWHUTOX* -,577,1996
TOXICOLOGY REVIEWMUREAV 705,184,2010
TOXICOLOGY REVIEWMUREAV 721,27,2011
TOXICOLOGY REVIEWRTOPDW 55,200,2009
TOXICOLOGY REVIEWRTOPDW 56,67,2010
TOXICOLOGY REVIEWRTOPDW 60,120,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 10 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 10 mg/m3, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 10 mg/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 10 mg/m3, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 10 mg/m3, short term exposure limit 20 mg/m3, NOV2011
Occupational Exposure Limit-FRANCEVME 10 mg/m3, FEB2006
Occupational Exposure Limit-GERMANYMAK 10 mg/m3, C carcinogen, 2011
Occupational Exposure Limit-GERMANYMAK 10 mg/m3, inhal, 2011
Occupational Exposure Limit-ICELANDtime-weighted average 10 mg/m3, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 10 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 10 mg/m3;short term exposure limit 20 mg/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 10 mg/m3, JAN2002
Occupational Exposure Limit-SWITZERLANDMAK-week 10 mg/m3, inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 10 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 10 mg/m3, OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 2,6-DI-t-BUTYL-p-CRESOL-air10H time-weighted average 10 mg/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 83383; Number of Industries 210; Total Number of Facilities 27242; Number of Occupations 154; Total Number of Employees Exposed 591238; Total Number of Female Employees Exposed 163774
National Occupational Hazard Survey 1974Hazard Code 83383; Number of Industries 32; Total Number of Facilities 1526; Number of Occupations 39; Total Number of Employees Exposed 28860

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-reciprocal translocation
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus; Sperm morphology-mouse
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; Mouse specific locus
EPA GENETOX PROGRAM 1988, Positive: D melanogaster-whole sex chrom. loss
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9076
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,ratNCITR* NCI-TR-150,1979
Page last reviewed: November 16, 2018