Copper oxide

RTECS #

GL7900000

CAS #

1317-38-0
See: NMAM or OSHA Methods

Updated

March 2018

Molecular Weight

79.54

Molecular Formula

CuO

Synonyms

Black copper oxide
C.I. 77403
C.I. Pigment Black 15
Copper Brown
Copper monooxide
Copper monoxide
Copper(2+) oxide
Copper(II) oxide
Cupric oxide

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
DNA Damage	lung/human	20 µg/disk/4H	TOLED5 188,112,2009

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Hamster, ovary	Inhibitor Concentration Low: 27 ppm/24H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TOLED5 197,169,2010
In Vitro/Hamster, ovary	Inhibitor Concentration Low: 4.5 ppm/72H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TOLED5 197,169,2010
In Vitro/Human, HeLa cell	Inhibitor Concentration Low: 4.5 ppm/24H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TOLED5 197,169,2010
In Vitro/Human, HeLa cell	Inhibitor Concentration Low: 4.5 ppm/72H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TOLED5 197,169,2010
In Vitro/ppf	Inhibitor Concentration Low: 20 µg/well/2H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. In Vitro Toxicity Studies: Other assays	TIVIEQ 27,1287,2013
inhalation/guinea pig	lowest published toxic concentration: 1.6 mg/m³	Lung, Thorax, or Respiration: Other changes	HBTME* -,529,2007
intraperitoneal/mouse	lethal dose (50 percent kill): 273 mg/kg		VCVN1* -,67,1998
intraperitoneal/mouse	lowest published toxic dose: 45.4 mg/kg	Behavioral: Excitement Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Cough	VCVN1* -,67,1998
intratracheal/rat	lethal dose (50 percent kill): 250 mg/kg		VCVN1* -,68,1998
intratracheal/rat	lowest published lethal dose: 278 mg/kg		TPKVAL 11,47,1969
intratracheal/rat	lowest published toxic dose: 100 µg/kg	Lung, Thorax, or Respiration: Sputum	HBTME* -,529,2007
oral/rat	lethal dose (50 percent kill): 470 mg/kg		VCVN1* -,67,1998

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
oral/woman	lowest published toxic dose: 0.7 mg/kg/7D- continuous	Gastrointestinal: Hypermotility, diarrhea Gastrointestinal: Nausea or vomiting Gastrointestinal: Other changes	EVHPAZ 109,949,2001

Reviews

Organization	Standard	Reference
TOXICOLOGY REVIEW		HUTOX* -,661,1996
TOXICOLOGY REVIEW		MUREAV 727,72,2011
TOXICOLOGY REVIEW		MUTAEX 32,203,2017
TOXICOLOGY REVIEW		MUREAV 770,204,2016

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	Supported	RBREV* -,305,1998
Occupational Exposure Limit-FINLAND	time-weighted average 1 mg(Cu)/m³, NOV2011
Occupational Exposure Limit-GERMANY	MAK 0.1 mg(Cu)/m³, inhal, 2011
Occupational Exposure Limit-HUNGARY	time-weighted average 1 mg(Cu)/m³, short term exposure limit 4 mg(Cu)/m³, SEP2000
Occupational Exposure Limit-SWEDEN	time-weighted average 1 mg(Cu)/m³;time-weighted average 0.2 mg(Cu)/m³ (resp. dust), JUN2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 0.1 mg(Cu)/m³, KZG-week 0.2 mg(Cu)/m³, inhal, JAN2011

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Occupational Exposure Survey 1983	Hazard Code 81787; Number of Industries 16; Total Number of Facilities 1104; Number of Occupations 33; Total Number of Employees Exposed 17248; Total Number of Female Employees Exposed 4024
National Occupational Hazard Survey 1974	Hazard Code 81787; Number of Industries 15; Total Number of Facilities 378; Number of Occupations 27; Total Number of Employees Exposed 13362

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health