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Copper oxide

RTECS #
GL7900000
CAS #
1317-38-0
See: NMAM or OSHA Methods
Updated
March 2018
Molecular Weight
79.54
Molecular Formula
CuO
Synonyms
Black copper oxide
C.I. 77403
C.I. Pigment Black 15
Copper Brown
Copper monooxide
Copper monoxide
Copper(2+) oxide
Copper(II) oxide
Cupric oxide

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damagelung/human20 µg/disk/4HTOLED5 188,112,2009

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Hamster, ovary Inhibitor Concentration Low: 27 ppm/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TOLED5 197,169,2010
In Vitro/Hamster, ovary Inhibitor Concentration Low: 4.5 ppm/72HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TOLED5 197,169,2010
In Vitro/Human, HeLa cell Inhibitor Concentration Low: 4.5 ppm/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TOLED5 197,169,2010
In Vitro/Human, HeLa cell Inhibitor Concentration Low: 4.5 ppm/72HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TOLED5 197,169,2010
In Vitro/ppfInhibitor Concentration Low: 20 µg/well/2HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.

In Vitro Toxicity Studies: Other assays
TIVIEQ 27,1287,2013
inhalation/guinea pig lowest published toxic concentration: 1.6 mg/m3Lung, Thorax, or Respiration: Other changesHBTME* -,529,2007
intraperitoneal/mouse lethal dose (50 percent kill): 273 mg/kgVCVN1* -,67,1998
intraperitoneal/mouse lowest published toxic dose: 45.4 mg/kgBehavioral: Excitement

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough
VCVN1* -,67,1998
intratracheal/rat lethal dose (50 percent kill): 250 mg/kgVCVN1* -,68,1998
intratracheal/rat lowest published lethal dose: 278 mg/kgTPKVAL 11,47,1969
intratracheal/rat lowest published toxic dose: 100 µg/kgLung, Thorax, or Respiration: SputumHBTME* -,529,2007
oral/rat lethal dose (50 percent kill): 470 mg/kgVCVN1* -,67,1998

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/woman lowest published toxic dose: 0.7 mg/kg/7D- continuousGastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting

Gastrointestinal: Other changes
EVHPAZ 109,949,2001

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWHUTOX* -,661,1996
TOXICOLOGY REVIEWMUREAV 727,72,2011
TOXICOLOGY REVIEWMUTAEX 32,203,2017
TOXICOLOGY REVIEWMUREAV 770,204,2016

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,305,1998
Occupational Exposure Limit-FINLANDtime-weighted average 1 mg(Cu)/m3, NOV2011
Occupational Exposure Limit-GERMANYMAK 0.1 mg(Cu)/m3, inhal, 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 1 mg(Cu)/m3, short term exposure limit 4 mg(Cu)/m3, SEP2000
Occupational Exposure Limit-SWEDENtime-weighted average 1 mg(Cu)/m3;time-weighted average 0.2 mg(Cu)/m3 (resp. dust), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 mg(Cu)/m3, KZG-week 0.2 mg(Cu)/m3, inhal, JAN2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 81787; Number of Industries 16; Total Number of Facilities 1104; Number of Occupations 33; Total Number of Employees Exposed 17248; Total Number of Female Employees Exposed 4024
National Occupational Hazard Survey 1974Hazard Code 81787; Number of Industries 15; Total Number of Facilities 378; Number of Occupations 27; Total Number of Employees Exposed 13362

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
Page last reviewed: November 16, 2018