Chlorine fluoride
RTECS #
FO2800000
CAS #
Updated
December 2018
Molecular Weight
92.45
Molecular Formula
ClF3
Synonyms
Chlorine trifluoride
Chlorine trifluoride (ACGIH:OSHA)
Chlorotrifluoride
Trifluorure de chlore (French)
Chlorine trifluoride (ACGIH:OSHA)
Chlorotrifluoride
Trifluorure de chlore (French)
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| eye /Dog | 21 ppm/12H- intermittent | AMIHAB 12,515,1955 | |
| eye /rat | 21 ppm/12H- intermittent | AMIHAB 12,515,1955 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/Dog | lowest published toxic concentration: 1800 mg/m3/2M | Olfaction: Other olfaction effects Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Cough | VCVN5* -,386,1989 |
| inhalation/Dog | lowest published toxic concentration: 1800 mg/m3/5M | Eye: Lacrimation Eye: Corneal damage | VCVN5* -,386,1989 |
| inhalation/Dog | Lowest published lethal concentration: 360 mg/m3/4H | VCVN5* -,386,1989 | |
| inhalation/human | Lowest published lethal concentration: 50 ppm | 34ZIAG -,651,1966 | |
| inhalation/mammal (species unspecified) | lowest published toxic concentration: 80 mg/m3/10M | Lung, Thorax, or Respiration: Cough | VCVN5* -,386,1989 |
| inhalation/monkey | lethal concentration (50 percent kill): 230 ppm/1H | Behavioral: Muscle weakness Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Lung, Thorax, or Respiration: Cyanosis | AMRL** TR-70-77,1970 |
| inhalation/mouse | lethal concentration (50 percent kill): 178 ppm/1H | Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Lung, Thorax, or Respiration: Cyanosis | AMRL** TR-70-77,1970 |
| inhalation/rabbit | Lowest published lethal concentration: 360 mg/m3/4H | VCVN5* -,386,1989 | |
| inhalation/rabbit | lowest published toxic concentration: 1800 mg/m3/5M | Eye: Lacrimation Eye: Corneal damage | VCVN5* -,386,1989 |
| inhalation/rabbit | lowest published toxic concentration: 1800 mg/m3/2M | Olfaction: Other olfaction effects Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Cough | VCVN5* -,386,1989 |
| inhalation/rat | Lowest published lethal concentration: 3000 mg/m3/15M | VCVN5* -,385,1989 | |
| inhalation/rat | Lowest published lethal concentration: 1500 mg/m3/35M | VCVN5* -,386,1989 | |
| inhalation/rat | lethal concentration (50 percent kill): 299 ppm/1H | TXAPA9 42,417,1977 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/Dog | lowest published toxic concentration: 5150 ppb/6H/6W- intermittent | Eye: Corneal damage Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis) Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | AMIHAB 12,515,1955 |
| inhalation/Dog | lowest published toxic concentration: 1170 ppb/6H/26W- intermittent | Eye: Lacrimation Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis) Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | AMIHAB 13,340,1956 |
| inhalation/Dog | lowest published toxic concentration: 20 mg/m3/6H/6W- intermittent | Lung, Thorax, or Respiration: Emphysema Lung, Thorax, or Respiration: Acute pulmonary edema Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | VCVN5* -,386,1989 |
| inhalation/mammal (species unspecified) | lowest published toxic concentration: 4 mg/m3/6H/26W- intermittent | Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Cough | VCVN5* -,386,1989 |
| inhalation/mammal (species unspecified) | lowest published toxic concentration: 4 mg/m3/6H/8W- intermittent | Lung, Thorax, or Respiration: Other changes | VCVN5* -,386,1989 |
| inhalation/mammal (species unspecified) | lowest published toxic concentration: 2 mg/m3/17W- intermittent | Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Other changes Musculoskeletal: Other changes | STGNBT -,239,1999 |
| inhalation/rat | lowest published toxic concentration: 20 mg/m3/6H/6W- intermittent | Lung, Thorax, or Respiration: Emphysema Lung, Thorax, or Respiration: Acute pulmonary edema Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | VCVN5* -,386,1989 |
| inhalation/rat | lowest published toxic concentration: 5150 ppb/6H/6W- intermittent | Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Gastrointestinal: Changes in structure or function of salivary glands Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | AMIHAB 12,515,1955 |
| inhalation/rat | lowest published toxic concentration: 1170 ppb/6H/26W- intermittent | Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | AMIHAB 13,340,1956 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-ceiling concentration 0.1 ppm | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 2.5 mg(F)/m3 | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | TXAPA9 27,527,1974 | |
| TOXICOLOGY REVIEW | RTOPDW 54,247,2009 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Mine Safety and Health Administration (MSHA) STANDARD | air-ceiling concentration 0.1 ppm (0.4 mg/m3) | DTLWS* 3,11,1972 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | ceiling concentration 0.1 ppm (0.38 mg/m3), JUL2008 | |
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 2.5 mg(F)/m3, JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 0.1 ppm (0.4 mg/m3);KZW 0.2 ppm (0.8 mg/m3), 2007 | |
| Occupational Exposure Limit-BELGIUM | short term exposure limit 0.1 ppm (0.39 mg/m3), MAR2002 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 2.5 mg(F)/m3, MAR2002 | |
| Occupational Exposure Limit-DENMARK | ceiling concentration 0.1 ppm (0.4 mg/m3), MAY2011 | |
| Occupational Exposure Limit-EC | time-weighted average 2.5 mg(F)/m3, JUN2000 | |
| Occupational Exposure Limit-FINLAND | short term exposure limit 0.1 ppm (0.38 mg/m3), NOV2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 2.5 mg(F)/m3, NOV2011 | |
| Occupational Exposure Limit-FRANCE | VLE 0.4 mg/m3, FEB2006 | |
| Occupational Exposure Limit-GERMANY | MAK 1 mg(F)/m3, inhal, 2011 | |
| Occupational Exposure Limit-HUNGARY | time-weighted average 2.5 mg(F)/m3, short term exposure limit 10 mg(F)/m3, Skin, SEP2000 | |
| Occupational Exposure Limit-ICELAND | short term exposure limit 0.1 ppm (0.4 mg/m3), NOV2011 | |
| Occupational Exposure Limit-KOREA | ceiling concentration 0.1 ppm (0.4 mg/m3), 2006 | |
| Occupational Exposure Limit-MEXICO | peak 0.1 ppm (0.4 mg/m3), 2004 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 2.5 mg(F)/m3, 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | ceiling concentration 0.1 ppm (0.38 mg/m3), JAN2002 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 2.5 mg(F)/m3, JAN2002 | |
| Occupational Exposure Limit-PERU | short term exposure limit 0,1 ppm (0,38 mg/m3), JUL2005 | |
| Occupational Exposure Limit-POLAND | MAC(time-weighted average) 1 mg(HF)/m3, MAC(short term exposure limit) 3 mg(HF)/m3, JAN1999 | |
| Occupational Exposure Limit-SWITZERLAND | ceiling concentration 0.1 ppm (0.4 mg/m3), JAN2011 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 1 mg(F)/m3, KZG-week 4 mg(F)/m3, inhal, skin, JAN2011 | |
| Occupational Exposure Limit-THAILAND | time-weighted average 0.1 ppm (0.4 mg/m3), JAN1993 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-C 0.4 mg/m3, 2003 | |
| Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 0.1 ppm (0.4 mg/m3), JAN1993 | |
| Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 2.5 mg(F)/m3, OCT2007 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | ceiling concentration 0.1 ppm (0.4 mg/m3) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | ceiling concentration 0.1 ppm (0.4 mg/m3) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | ceiling concentration 0.1 ppm (0.4 mg/m3) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | ceiling concentration 0.1 ppm (0.4 mg/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CHLORINE TRIFLUORIDE-air | ceiling concentration 0.1 ppm | NIOSH* DHHS #92-100,1992 |
| National Occupational Hazard Survey 1974 | Hazard Code 18050; Number of Industries 1; Total Number of Facilities 11; Number of Occupations 3; Total Number of Employees Exposed 357 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA TSCA Section 8(b) CHEMICAL INVENTORY |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health