Carbamic acid, methyl-, 2,3-dihydro-2,2-dimethyl-7-benzofuranyl ester

RTECS #

FB9450000

CAS #

1563-66-2
See: NMAM or OSHA Methods

Updated

September 2018

Molecular Weight

221.28

Molecular Formula

C₁₂H₁₅NO₃

Synonyms

2,2-Dimethyl-2,3-dihydro-7-benzofuranyl N-methylcarbamate
2,2-Dimethyl-7-coumaranyl N-methylcarbamate
2,3-Dihydro-2,2-dimethyl-7-benzofuranyl methylcarbamate
2,3-Dihydro-2,2-dimethylbenzofuran-7-yl methylcarbamate
2,3-Dihydro-2,2-dimethylbenzofuranyl-7-N-methylcarbamate
7-Benzofuranol, 2,3-dihydro-2,2-dimethyl-, methylcarbamate (9CI)
BAY 70143
C2292-59A
Carbamic acid, methyl-, 2,2-dimethyl-2,3-dihydrobenzofuran-7-yl ester
Carbofuran
Carbofuran (ACGIH)
Carbofurane
Chinufur
Crisfuran
Curaterr
D 1221
ENT 27,164
FMC 10242
Furacarb
Furadan
Furadan 3G
Furadan 4F
Furadan 75 WP
Furadane
Furodan
Karbofuranu (Polish)
ME F248
Methyl carbamic acid 2,3-dihydro-2,2-dimethyl-7-benzofuranyl ester
NIA 10242
NIA 10242 75 WP
Niagara 10242
Niagara nia-10242
N-Metylokarbaminian 2,3-dwuwodoro-2,2-dwumetylobenzofuranylu-7 (Polish)
OMS-864
Yaltox

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
skin /rabbit	500 mg	mild	HPV028 -,-,2004

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Cytogenetic Analysis	lymphocyte/human	100 mg/L	TGANAK 18(1),17,1984
Cytogenetic Analysis	oral/mouse	3800 µg/kg	MUREAV 465,123,2000
Cytogenetic Analysis	ovary/hamster	0.15 mg/L/2H	FCTOD7 45,928,2007
DNA Damage	lymphocyte/human	8 µg/L/14D	TOLED5 211,62,2012
micronucleus test	oral/rat	15 mg/kg/5W	FCTOD7 65,115,2014
micronucleus test	ovary/hamster	10 mg/L/24H	MUREAV 656,68,2008
mutation in mammalian somatic cells	lung/hamster	500 µmol/L	ENVRAL 29,48,1982
mutation in microorganisms	/Salmonella typhimurium	10 mg/plate (+/-enzymatic activation step)	MUREAV 116,185,1983
mutation in microorganisms	/Other microorganisms	60 mg/L (-enzymatic activation step)	MILEDM 12,79,1979
mutation in microorganisms	/Salmonella typhimurium	1048 µg/plate (-enzymatic activation step)	HPV028 -,-,2004
other mutation test systems	oral/mouse	5700 µg/kg	MUREAV 465,123,2000
sister chromatid exchange	lymphocyte/human	5 mg/L	MUREAV 147,296,1985
sister chromatid exchange	ovary/hamster	10 mg/L/24H	MUREAV 656,68,2008
sperm morphology	intraperitoneal/mouse	2 mg/kg	MUREAV 465,123,2000

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
oral/rat	70 mg/kg (6-19D pregnant)	Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)	JPFCD2 20,373,1985
oral/rat	86 mg/kg (60D male)	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct	HETOEA 14,889,1995
oral/mouse	210 µg/kg (1-21D pregnant)	Reproductive: Effects on newborn: Biochemical and metabolic	JEPTDQ 2(2),357,1978
oral/mouse	10500 µg/kg (1-21D pregnant)	Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) Reproductive: Effects on newborn: Delayed effects	JEPTDQ 4(5-6),53,1980
oral/mouse	220 mg/kg (6-16D pregnant)	Reproductive: Specific developmental abnormalities: Musculoskeletal system	JPFCD2 20,373,1985
oral/mouse	110 mg/kg (6-16D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Effects on embryo or fetus: Fetal death	JPFCD2 20,373,1985
oral/man	6200 µg/kg (multigeneration)	Reproductive: Effects on newborn: Delayed effects	JRPFA4 113,95,1998
oral/rat	12 mg/kg (60D male)	Reproductive: Paternal effects: Testes, epididymis, sperm duct	TOXID9 -,193,2008
oral/rat	124.8 mg/kg (multigeneration)	Reproductive: Other effects on male Reproductive: Other effects on female Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	HPV028 -,-,2004

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Non-mammalian species, liver	Inhibitor Concentration Low: 0.01 µg/L	In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc. In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. In Vitro Toxicity Studies: Other assays	TIVIEQ 29,1377,2015
In Vitro/Non-mammalian species, liver	Inhibitor Concentration Low: 0.04 µg/L	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 29,1405,2015
In Vitro/Rat, neurons	Inhibitor Concentration (50 percent kill): 35.5 µmol/L/2H	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	TIVIEQ 3,111,1989
inhalation/Dog	lethal concentration (50 percent kill): 52 mg/m³	Eye: Other eye effects Gastrointestinal: Changes in structure or function of salivary glands Gastrointestinal: Nausea or vomiting	JJOMDZ 12,16,1970
inhalation/rat	lethal concentration (50 percent kill): 85 mg/m³	Eye: Other eye effects Gastrointestinal: Changes in structure or function of salivary glands Gastrointestinal: Nausea or vomiting	JJOMDZ 12,16,1970
inhalation/rat	lowest published toxic concentration: 50 mg/m³	Behavioral: Ataxia Lung, Thorax, or Respiration: Dyspnea Lung, Thorax, or Respiration: Other changes	HPV028 -,-,2004
intraperitoneal/rat	lowest published toxic dose: 1.5 mg/kg	Cardiac: Cardiomyopathy including infarction Musculoskeletal: Other changes Biochemical: Metabolism (intermediary): Other proteins	TXCYAC 266,48,2009
intraperitoneal/rat	lowest published toxic dose: 1.5 mg/kg	Cardiac: Other changes	TXCYAC 271,36,2010
intravenous/mouse	lethal dose (50 percent kill): 450 µg/kg		CSLNX* NX#11280
oral/chicken	lethal dose (50 percent kill): 6300 µg/kg	Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change Behavioral: Convulsions or effect on seizure threshold Behavioral: Ataxia	TXAPA9 11,49,1967
oral/Dog	lethal dose (50 percent kill): 19 mg/kg	Eye: Other eye effects Gastrointestinal: Changes in structure or function of salivary glands Gastrointestinal: Nausea or vomiting	JJOMDZ 12,16,1970
oral/Dog	lethal dose (50 percent kill): 19 mg/kg		HBPTO* 2,1094,2001
oral/domestic bird	lowest published toxic dose: 0.5 mg/kg	Liver: Hepatitis (hepatocellular necrosis), diffuse Blood: Hemorrhage Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases	TOXID9 90,322,2006
oral/duck	lethal dose (50 percent kill): 415 µg/kg		TXAPA9 22,556,1972
oral/man	lowest published toxic dose: 3571 mg/kg	Peripheral Nerve and Sensation: Fasciculations Cardiac: Change in rate Lung, Thorax, or Respiration: Dyspnea	JTCTDW 43,867,2005
oral/man	lowest published toxic dose: 1428.6 µL/kg	Peripheral Nerve and Sensation: Paresthesia Eye: Miosis (pupilliary constriction) Nutritional and Gross Metabolic: Body temperature increase	JTCTDW 38,43,2000
oral/man	lowest published toxic dose: 1.43 mL/kg	Peripheral Nerve and Sensation: Paresthesia Autonomic Nervous System: Other (direct) parasympathomimetic Behavioral: Muscle weakness	JTCTDW 38,43,2000
oral/mouse	lethal dose (50 percent kill): 2 mg/kg		HBPTO* 2,1094,2001
oral/pigeon	lowest published toxic dose: 0.5 mg/kg	Behavioral: Change in psychophysiological tests	TXAPA9 219,241,2007
oral/pigeon	lethal dose (50 percent kill): 1330 µg/kg		ASTTA8 (680),157,1979
oral/quail	lethal dose (50 percent kill): 3160 µg/kg		ASTTA8 (680),157,1979
oral/rat	lethal dose (50 percent kill): 5 mg/kg		PSSCBG 1,117,1970
oral/rat	lowest published toxic dose: 0.5 mg/kg	Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	TXAPA9 219,202,2007
oral/rat	lethal dose (50 percent kill): 8 mg/kg	Behavioral: Convulsions or effect on seizure threshold Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)	EKFAE9 55,51,1992
oral/rat	lowest published toxic dose: 0.5 mg/kg	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	TOXID9 72,305,2003
oral/rat	lowest published toxic dose: 1.5 mg/kg	Brain and Coverings: Other degenerative changes Biochemical: Metabolism (intermediary): Effect on cyclic nucleotides Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation	TOXID9 12,471,2008
oral/rat	lethal dose (50 percent kill): 8.8 mg/kg	Behavioral: Tremor Lung, Thorax, or Respiration: Acute pulmonary edema	HPV028 -,-,2004
oral/wild bird	lethal dose (50 percent kill): 420 µg/kg		TXAPA9 26,154,1973
oral/woman	lowest published toxic dose: 1200 µg/kg	Behavioral: Hallucinations, distorted perceptions Lung, Thorax, or Respiration: Dyspnea Skin and Appendages: Other: Sweating	KHZDAN 24,445,1981
skin/mammal (species unspecified)	lethal dose (50 percent kill): 837 mg/kg	Olfaction: Other olfaction effects Behavioral: Convulsions or effect on seizure threshold Gastrointestinal: Changes in structure or function of salivary glands	GISAAA 53(2),89,1988
skin/rabbit	lethal dose (50 percent kill): 885 mg/kg		GUCHAZ 6,81,1973
skin/rabbit	lowest published toxic dose: 2010 mg/kg	Eye: Miosis (pupilliary constriction) Behavioral: Tremor Kidney, Ureter, and Bladder: Hematuria	HPV028 -,-,2004
skin/rat	lethal dose (50 percent kill): 120 mg/kg		WRPCA2 9,119,1970
skin/wild bird	lethal dose (50 percent kill): 100 mg/kg		TXAPA9 26,154,1973
subcutaneous/rat	lowest published toxic dose: 1.5 mg/kg	Behavioral: Convulsions or effect on seizure threshold Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	TOXID9 44,204,2005
subcutaneous/rat	lowest published toxic dose: 1.5 mg/kg	Biochemical: Metabolism (intermediary): Other	TOXID9 44,204,2005
subcutaneous/rat	lowest published toxic dose: 1.5 mg/kg	Behavioral: Convulsions or effect on seizure threshold Gastrointestinal: Changes in structure or function of salivary glands Biochemical: Metabolism (intermediary): Lipids including transport	TXCYAC 208,13,2005
subcutaneous/rat	lowest published toxic dose: 1.5 mg/kg	Endocrine: Estrogenic Endocrine: Hypoglycemia Nutritional and Gross Metabolic: Body temperature decrease	TOXID9 78,117,2004
subcutaneous/rat	lowest published toxic dose: 1.25 mg/kg	Brain and Coverings: Other degenerative changes Biochemical: Metabolism (intermediary): Effect on mitochondrial function Biochemical: Metabolism (intermediary): Other	TOXID9 1,49,2001
subcutaneous/rat	lowest published toxic dose: 1.5 mg/kg	Peripheral Nerve and Sensation: Fasciculations Musculoskeletal: Other changes Biochemical: Metabolism (intermediary): Effect on cyclic nucleotides	TOXID9 78,309,2004
subcutaneous/rat	lowest published toxic dose: 1.5 mg/kg	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Metabolism (intermediary): Lipids including transport Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation	TOXID9 90,102,2006
subcutaneous/rat	lowest published toxic dose: 1.5 mg/kg	Brain and Coverings: Other degenerative changes Peripheral Nerve and Sensation: Fasciculations Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	TXAPA9 219,97,2007
Tank with water/Carp	Inhibitor Concentration Low: 50 µg/L/96H	Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes	TOLED5 196S,S114,2010
Tank with water/Carp	Inhibitor Concentration Low: 50 µg/L/28D	Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes	TOLED5 196S,S114,2010
unreported route/mouse	lethal dose (50 percent kill): 5 mg/kg		GISAAA 49(10),23,1984
unreported route/rabbit	lethal dose (50 percent kill): 885 mg/kg		30ZDA9 -,192,1971
unreported route/rat	lethal dose (50 percent kill): 19 mg/kg		GISAAA 49(10),23,1984
unreported route/rat	lethal dose (50 percent kill): 8 mg/kg	Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)	FATOAO 50,97,1987

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
intraperitoneal/mammal (species unspecified)	lowest published toxic dose: 10.5 mg/kg/6W- intermittent	Blood: Other changes	HBPTO* 1,776,2001
intraperitoneal/mouse	lowest published toxic dose: 3 mg/kg/6W- intermittent	Brain and Coverings: Other degenerative changes Liver: Other changes Biochemical: Metabolism (intermediary): Lipids including transport	TXCYAC 38,69,1986
multiple/non-mammalian species	lowest published toxic dose: 50 mg/m³/7D- continuous	Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases	TXCYAC 212,107,2005
oral/chicken	lowest published toxic dose: 1960 mg/kg/2W- continuous	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	TXAPA9 11,49,1967
oral/Dog	lowest published toxic dose: 4550 mg/kg/1Y- continuous	Blood: Other changes Blood: Changes in erythrocyte (RBC) count Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	RCTOE4 104,35,1988
oral/mouse	lowest published toxic dose: 39 mg/kg/30D- intermittent	Reproductive: Maternal effects: Oogenesis Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Changes in ovarian weight	BECTA6 71,422,2003
oral/mouse	lowest published toxic dose: 10.5 mg/kg/15D- intermittent	Endocrine: Differential effect of sex or castration on observed toxicity Related to Chronic Data: Changes in ovarian weight	TXCYAC 204,87,2004
oral/mouse	lowest published toxic dose: 13686 mg/kg/2Y- continuous	Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	RCTOE4 104,35,1988
oral/rabbit	lowest published toxic dose: 0.99 mg/kg/33D- continuous	Immunological Including Allergic: Decrease in humoral immune response	TXAPA9 32,587,1975
oral/rabbit	lowest published toxic dose: 1.71 mg/kg/57D- continuous	Blood: Changes in spleen	TXAPA9 32,587,1975
oral/rabbit	lowest published toxic dose: 1.32 mg/kg/44D- continuous	Immunological Including Allergic: Decreased immune response	TXAPA9 32,587,1975
oral/rat	lowest published toxic dose: 21 mg/kg/30D- intermittent	Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS	BCTKAG 14,289,1981
oral/rat	lowest published toxic dose: 3640 mg/kg/2Y- continuous	Brain and Coverings: Other degenerative changes Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	RCTOE4 104,35,1988
oral/rat	lowest published toxic dose: 12 mg/kg/60D- intermittent	Endocrine: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain	TOXID9 -,193,2008
oral/rat	lowest published toxic dose: 900 mg/kg/24W- intermittent	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	HPV028 -,-,2004
oral/rat	lowest published toxic dose: 30 mg/kg/5W- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	FCTOD7 65,115,2014
oral/rat	lowest published toxic dose: 15 mg/kg/5W- intermittent	Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases	FCTOD7 65,115,2014
oral/wild bird	lowest published toxic dose: 71600 µg/kg/7D- continuous	Behavioral: Somnolence (general depressed activity) Behavioral: Food intake (animal) Nutritional and Gross Metabolic: Weight loss or decreased weight gain	AECTCV 11,611,1982
skin/rabbit	lowest published toxic dose: 17 gm/kg/20D- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	JJOMDZ 12,16,1970
skin/rat	lowest published toxic dose: 5250 mg/kg/21D- intermittent	Behavioral: Tremor Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	TOXID9 -,55,2008

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 0.1 mg/m³ (inhal, vapor)	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		JAVMA4 164,277,1974
TOXICOLOGY REVIEW		TOLED5 128,45,2002
TOXICOLOGY REVIEW		MUREAV 562,77,2004
TOXICOLOGY REVIEW		MUTAEX 21,93,2006
TOXICOLOGY REVIEW		NETOX* 26,531,2005
TOXICOLOGY REVIEW		HTOPA* 1,501,2002
TOXICOLOGY REVIEW		FEREAC 73,44864,2008
TOXICOLOGY REVIEW		FEREAC 74,23046,2009
TOXICOLOGY REVIEW		NETEEC 33,608,2011
TOXICOLOGY REVIEW		TXCYAC 307,42,2013
TOXICOLOGY REVIEW		TXCYAC 307,123,2013
TOXICOLOGY REVIEW		TOLED5 230,146,2014
TOXICOLOGY REVIEW		TXAPA9 268,157,2013
TOXICOLOGY REVIEW		FCTOD7 105,456,2017

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	Supported	RBREV* -,94,1998
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 0.1 mg/m³, JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 0.1 mg/m³;KZW 0.2 mg/m³, inhal, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 0.1 mg/m³, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 0.1 mg/m³, MAY2011
Occupational Exposure Limit-FRANCE	VME 0.1 mg/m³, FEB2006
Occupational Exposure Limit-ICELAND	time-weighted average 0.1 mg/m³, NOV2011
Occupational Exposure Limit-INDIA	time-weighted average 0.1 mg/m³, JAN1993
Occupational Exposure Limit-KOREA	time-weighted average 0.1 mg/m³, 2006
Occupational Exposure Limit-MEXICO	time-weighted average 0.1 mg/m³, 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 0.1 mg/m³, JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 0.1 mg/m³, JAN1999
Occupational Exposure Limit-PERU	time-weighted average 0.1 mg/m³, JUL2005
Occupational Exposure Limit-POLAND	MAC(time-weighted average) 0.1 mg/m³, JAN1999
Occupational Exposure Limit-SWITZERLAND	MAK-week 0.1 mg/m³, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 0.1 mg/m³, 2003

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CARBOFURAN-air	10H time-weighted average 0.1 mg/m³	NIOSH* DHHS #95-121,1995

Status in Federal Agencies

Organization	Reference
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA without S9
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health