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Carbamic acid, methyl-, 2,3-dihydro-2,2-dimethyl-7-benzofuranyl ester

RTECS #
FB9450000
CAS #
1563-66-2
See: NMAM or OSHA Methods
Updated
September 2018
Molecular Weight
221.28
Molecular Formula
C12H15NO3
Synonyms
2,2-Dimethyl-2,3-dihydro-7-benzofuranyl N-methylcarbamate
2,2-Dimethyl-7-coumaranyl N-methylcarbamate
2,3-Dihydro-2,2-dimethyl-7-benzofuranyl methylcarbamate
2,3-Dihydro-2,2-dimethylbenzofuran-7-yl methylcarbamate
2,3-Dihydro-2,2-dimethylbenzofuranyl-7-N-methylcarbamate
7-Benzofuranol, 2,3-dihydro-2,2-dimethyl-, methylcarbamate (9CI)
BAY 70143
C2292-59A
Carbamic acid, methyl-, 2,2-dimethyl-2,3-dihydrobenzofuran-7-yl ester
Carbofuran
Carbofuran (ACGIH)
Carbofurane
Chinufur
Crisfuran
Curaterr
D 1221
ENT 27,164
FMC 10242
Furacarb
Furadan
Furadan 3G
Furadan 4F
Furadan 75 WP
Furadane
Furodan
Karbofuranu (Polish)
ME F248
Methyl carbamic acid 2,3-dihydro-2,2-dimethyl-7-benzofuranyl ester
NIA 10242
NIA 10242 75 WP
Niagara 10242
Niagara nia-10242
N-Metylokarbaminian 2,3-dwuwodoro-2,2-dwumetylobenzofuranylu-7 (Polish)
OMS-864
Yaltox

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 500 mg mildHPV028 -,-,2004

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislymphocyte/human100 mg/LTGANAK 18(1),17,1984
Cytogenetic Analysisoral/mouse3800 µg/kgMUREAV 465,123,2000
Cytogenetic Analysisovary/hamster0.15 mg/L/2HFCTOD7 45,928,2007
DNA Damagelymphocyte/human8 µg/L/14DTOLED5 211,62,2012
micronucleus testoral/rat15 mg/kg/5WFCTOD7 65,115,2014
micronucleus testovary/hamster10 mg/L/24HMUREAV 656,68,2008
mutation in mammalian somatic cellslung/hamster500 µmol/LENVRAL 29,48,1982
mutation in microorganisms/Salmonella typhimurium10 mg/plate (+/-enzymatic activation step)MUREAV 116,185,1983
mutation in microorganisms/Other microorganisms60 mg/L (-enzymatic activation step)MILEDM 12,79,1979
mutation in microorganisms/Salmonella typhimurium1048 µg/plate (-enzymatic activation step)HPV028 -,-,2004
other mutation test systemsoral/mouse5700 µg/kgMUREAV 465,123,2000
sister chromatid exchangelymphocyte/human5 mg/LMUREAV 147,296,1985
sister chromatid exchangeovary/hamster10 mg/L/24HMUREAV 656,68,2008
sperm morphologyintraperitoneal/mouse2 mg/kgMUREAV 465,123,2000

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 70 mg/kg (6-19D pregnant)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
JPFCD2 20,373,1985
oral/rat 86 mg/kg (60D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
HETOEA 14,889,1995
oral/mouse 210 µg/kg (1-21D pregnant)Reproductive: Effects on newborn: Biochemical and metabolicJEPTDQ 2(2),357,1978
oral/mouse 10500 µg/kg (1-21D pregnant)Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Delayed effects
JEPTDQ 4(5-6),53,1980
oral/mouse 220 mg/kg (6-16D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemJPFCD2 20,373,1985
oral/mouse 110 mg/kg (6-16D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
JPFCD2 20,373,1985
oral/man 6200 µg/kg (multigeneration)Reproductive: Effects on newborn: Delayed effectsJRPFA4 113,95,1998
oral/rat 12 mg/kg (60D male)Reproductive: Paternal effects: Testes, epididymis, sperm ductTOXID9 -,193,2008
oral/rat 124.8 mg/kg (multigeneration)Reproductive: Other effects on male

Reproductive: Other effects on female

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
HPV028 -,-,2004

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Non-mammalian species, liver Inhibitor Concentration Low: 0.01 µg/LIn Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.

In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.

In Vitro Toxicity Studies: Other assays
TIVIEQ 29,1377,2015
In Vitro/Non-mammalian species, liver Inhibitor Concentration Low: 0.04 µg/LIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 29,1405,2015
In Vitro/Rat, neurons Inhibitor Concentration (50 percent kill): 35.5 µmol/L/2HBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseTIVIEQ 3,111,1989
inhalation/Dog lethal concentration (50 percent kill): 52 mg/m3Eye: Other eye effects

Gastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Nausea or vomiting
JJOMDZ 12,16,1970
inhalation/rat lethal concentration (50 percent kill): 85 mg/m3Eye: Other eye effects

Gastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Nausea or vomiting
JJOMDZ 12,16,1970
inhalation/rat lowest published toxic concentration: 50 mg/m3Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes
HPV028 -,-,2004
intraperitoneal/rat lowest published toxic dose: 1.5 mg/kgCardiac: Cardiomyopathy including infarction

Musculoskeletal: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TXCYAC 266,48,2009
intraperitoneal/rat lowest published toxic dose: 1.5 mg/kgCardiac: Other changesTXCYAC 271,36,2010
intravenous/mouse lethal dose (50 percent kill): 450 µg/kgCSLNX* NX#11280
oral/chicken lethal dose (50 percent kill): 6300 µg/kgPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia
TXAPA9 11,49,1967
oral/Dog lethal dose (50 percent kill): 19 mg/kgEye: Other eye effects

Gastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Nausea or vomiting
JJOMDZ 12,16,1970
oral/Dog lethal dose (50 percent kill): 19 mg/kgHBPTO* 2,1094,2001
oral/domestic bird lowest published toxic dose: 0.5 mg/kgLiver: Hepatitis (hepatocellular necrosis), diffuse

Blood: Hemorrhage

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
TOXID9 90,322,2006
oral/duck lethal dose (50 percent kill): 415 µg/kgTXAPA9 22,556,1972
oral/man lowest published toxic dose: 3571 mg/kgPeripheral Nerve and Sensation: Fasciculations

Cardiac: Change in rate

Lung, Thorax, or Respiration: Dyspnea
JTCTDW 43,867,2005
oral/man lowest published toxic dose: 1428.6 µL/kgPeripheral Nerve and Sensation: Paresthesia

Eye: Miosis (pupilliary constriction)

Nutritional and Gross Metabolic: Body temperature increase
JTCTDW 38,43,2000
oral/man lowest published toxic dose: 1.43 mL/kgPeripheral Nerve and Sensation: Paresthesia

Autonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Muscle weakness
JTCTDW 38,43,2000
oral/mouse lethal dose (50 percent kill): 2 mg/kgHBPTO* 2,1094,2001
oral/pigeon lowest published toxic dose: 0.5 mg/kgBehavioral: Change in psychophysiological testsTXAPA9 219,241,2007
oral/pigeon lethal dose (50 percent kill): 1330 µg/kgASTTA8 (680),157,1979
oral/quail lethal dose (50 percent kill): 3160 µg/kgASTTA8 (680),157,1979
oral/rat lethal dose (50 percent kill): 5 mg/kgPSSCBG 1,117,1970
oral/rat lowest published toxic dose: 0.5 mg/kgBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TXAPA9 219,202,2007
oral/rat lethal dose (50 percent kill): 8 mg/kgBehavioral: Convulsions or effect on seizure threshold

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
EKFAE9 55,51,1992
oral/rat lowest published toxic dose: 0.5 mg/kgBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 72,305,2003
oral/rat lowest published toxic dose: 1.5 mg/kgBrain and Coverings: Other degenerative changes

Biochemical: Metabolism (intermediary): Effect on cyclic nucleotides

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOXID9 12,471,2008
oral/rat lethal dose (50 percent kill): 8.8 mg/kgBehavioral: Tremor

Lung, Thorax, or Respiration: Acute pulmonary edema
HPV028 -,-,2004
oral/wild bird lethal dose (50 percent kill): 420 µg/kgTXAPA9 26,154,1973
oral/woman lowest published toxic dose: 1200 µg/kgBehavioral: Hallucinations, distorted perceptions

Lung, Thorax, or Respiration: Dyspnea

Skin and Appendages: Other: Sweating
KHZDAN 24,445,1981
skin/mammal (species unspecified) lethal dose (50 percent kill): 837 mg/kgOlfaction: Other olfaction effects

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands
GISAAA 53(2),89,1988
skin/rabbit lethal dose (50 percent kill): 885 mg/kgGUCHAZ 6,81,1973
skin/rabbit lowest published toxic dose: 2010 mg/kgEye: Miosis (pupilliary constriction)

Behavioral: Tremor

Kidney, Ureter, and Bladder: Hematuria
HPV028 -,-,2004
skin/rat lethal dose (50 percent kill): 120 mg/kgWRPCA2 9,119,1970
skin/wild bird lethal dose (50 percent kill): 100 mg/kgTXAPA9 26,154,1973
subcutaneous/rat lowest published toxic dose: 1.5 mg/kgBehavioral: Convulsions or effect on seizure threshold

Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 44,204,2005
subcutaneous/rat lowest published toxic dose: 1.5 mg/kgBiochemical: Metabolism (intermediary): OtherTOXID9 44,204,2005
subcutaneous/rat lowest published toxic dose: 1.5 mg/kgBehavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands

Biochemical: Metabolism (intermediary): Lipids including transport
TXCYAC 208,13,2005
subcutaneous/rat lowest published toxic dose: 1.5 mg/kgEndocrine: Estrogenic

Endocrine: Hypoglycemia

Nutritional and Gross Metabolic: Body temperature decrease
TOXID9 78,117,2004
subcutaneous/rat lowest published toxic dose: 1.25 mg/kgBrain and Coverings: Other degenerative changes

Biochemical: Metabolism (intermediary): Effect on mitochondrial function

Biochemical: Metabolism (intermediary): Other
TOXID9 1,49,2001
subcutaneous/rat lowest published toxic dose: 1.5 mg/kgPeripheral Nerve and Sensation: Fasciculations

Musculoskeletal: Other changes

Biochemical: Metabolism (intermediary): Effect on cyclic nucleotides
TOXID9 78,309,2004
subcutaneous/rat lowest published toxic dose: 1.5 mg/kgBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport

Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation
TOXID9 90,102,2006
subcutaneous/rat lowest published toxic dose: 1.5 mg/kgBrain and Coverings: Other degenerative changes

Peripheral Nerve and Sensation: Fasciculations

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TXAPA9 219,97,2007
Tank with water/Carp Inhibitor Concentration Low: 50 µg/L/96HLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
TOLED5 196S,S114,2010
Tank with water/Carp Inhibitor Concentration Low: 50 µg/L/28DLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
TOLED5 196S,S114,2010
unreported route/mouse lethal dose (50 percent kill): 5 mg/kgGISAAA 49(10),23,1984
unreported route/rabbit lethal dose (50 percent kill): 885 mg/kg30ZDA9 -,192,1971
unreported route/rat lethal dose (50 percent kill): 19 mg/kgGISAAA 49(10),23,1984
unreported route/rat lethal dose (50 percent kill): 8 mg/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)FATOAO 50,97,1987

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mammal (species unspecified) lowest published toxic dose: 10.5 mg/kg/6W- intermittentBlood: Other changesHBPTO* 1,776,2001
intraperitoneal/mouse lowest published toxic dose: 3 mg/kg/6W- intermittentBrain and Coverings: Other degenerative changes

Liver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
TXCYAC 38,69,1986
multiple/non-mammalian species lowest published toxic dose: 50 mg/m3/7D- continuousBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases
TXCYAC 212,107,2005
oral/chicken lowest published toxic dose: 1960 mg/kg/2W- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldTXAPA9 11,49,1967
oral/Dog lowest published toxic dose: 4550 mg/kg/1Y- continuousBlood: Other changes

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
RCTOE4 104,35,1988
oral/mouse lowest published toxic dose: 39 mg/kg/30D- intermittentReproductive: Maternal effects: Oogenesis

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in ovarian weight
BECTA6 71,422,2003
oral/mouse lowest published toxic dose: 10.5 mg/kg/15D- intermittentEndocrine: Differential effect of sex or castration on observed toxicity

Related to Chronic Data: Changes in ovarian weight
TXCYAC 204,87,2004
oral/mouse lowest published toxic dose: 13686 mg/kg/2Y- continuousBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
RCTOE4 104,35,1988
oral/rabbit lowest published toxic dose: 0.99 mg/kg/33D- continuousImmunological Including Allergic: Decrease in humoral immune responseTXAPA9 32,587,1975
oral/rabbit lowest published toxic dose: 1.71 mg/kg/57D- continuousBlood: Changes in spleenTXAPA9 32,587,1975
oral/rabbit lowest published toxic dose: 1.32 mg/kg/44D- continuousImmunological Including Allergic: Decreased immune responseTXAPA9 32,587,1975
oral/rat lowest published toxic dose: 21 mg/kg/30D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS
BCTKAG 14,289,1981
oral/rat lowest published toxic dose: 3640 mg/kg/2Y- continuousBrain and Coverings: Other degenerative changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
RCTOE4 104,35,1988
oral/rat lowest published toxic dose: 12 mg/kg/60D- intermittentEndocrine: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOXID9 -,193,2008
oral/rat lowest published toxic dose: 900 mg/kg/24W- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
HPV028 -,-,2004
oral/rat lowest published toxic dose: 30 mg/kg/5W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainFCTOD7 65,115,2014
oral/rat lowest published toxic dose: 15 mg/kg/5W- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
FCTOD7 65,115,2014
oral/wild bird lowest published toxic dose: 71600 µg/kg/7D- continuousBehavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
AECTCV 11,611,1982
skin/rabbit lowest published toxic dose: 17 gm/kg/20D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldJJOMDZ 12,16,1970
skin/rat lowest published toxic dose: 5250 mg/kg/21D- intermittentBehavioral: Tremor

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOXID9 -,55,2008

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.1 mg/m3 (inhal, vapor)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWJAVMA4 164,277,1974
TOXICOLOGY REVIEWTOLED5 128,45,2002
TOXICOLOGY REVIEWMUREAV 562,77,2004
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWNETOX* 26,531,2005
TOXICOLOGY REVIEWHTOPA* 1,501,2002
TOXICOLOGY REVIEWFEREAC 73,44864,2008
TOXICOLOGY REVIEWFEREAC 74,23046,2009
TOXICOLOGY REVIEWNETEEC 33,608,2011
TOXICOLOGY REVIEWTXCYAC 307,42,2013
TOXICOLOGY REVIEWTXCYAC 307,123,2013
TOXICOLOGY REVIEWTOLED5 230,146,2014
TOXICOLOGY REVIEWTXAPA9 268,157,2013
TOXICOLOGY REVIEWFCTOD7 105,456,2017

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,94,1998
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.1 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.1 mg/m3;KZW 0.2 mg/m3, inhal, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 mg/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.1 mg/m3, MAY2011
Occupational Exposure Limit-FRANCEVME 0.1 mg/m3, FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 0.1 mg/m3, NOV2011
Occupational Exposure Limit-INDIAtime-weighted average 0.1 mg/m3, JAN1993
Occupational Exposure Limit-KOREAtime-weighted average 0.1 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.1 mg/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.1 mg/m3, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.1 mg/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0.1 mg/m3, JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.1 mg/m3, JAN1999
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 mg/m3, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.1 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CARBOFURAN-air10H time-weighted average 0.1 mg/m3NIOSH* DHHS #95-121,1995

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA without S9
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
Page last reviewed: November 16, 2018