2-Butanone, peroxide
RTECS #
EL9450000
CAS #
Updated
September 2013
Molecular Weight
176.24
Molecular Formula
C8H16O4
Synonyms
Butanox LPT
Butanox M 105
Butanox M 50
Chaloxyd MEKP-HA 1
Chaloxyd MEKP-LA 1
Esperfoam FR
Ethyl methyl ketone peroxide
FR 222
HI-Point 180
HI-Point 90
HI-Point PD-1
Kayamek A
Kayamek M
Ketonox
Lucidol DDM 9
Lucidol Delta X
Lupersol DDA 30
Lupersol DDM
Lupersol Delta X
Lupersol DNF
Lupersol DSW
MEK peroxide
MEKPO
Mepox
Methyl ethyl ketone hydroperoxide
Methyl ethyl ketone peroxide
Methyl ethyl ketone peroxide (ACGIH)
Methylethylketonhydroperoxide
NCI-C55447
Permek G
Permek N
Quickset Extra
Quickset super
RCRA waste number U160
Sprayset MEKP
Superox 46-710
Thermacure
Butanox M 105
Butanox M 50
Chaloxyd MEKP-HA 1
Chaloxyd MEKP-LA 1
Esperfoam FR
Ethyl methyl ketone peroxide
FR 222
HI-Point 180
HI-Point 90
HI-Point PD-1
Kayamek A
Kayamek M
Ketonox
Lucidol DDM 9
Lucidol Delta X
Lupersol DDA 30
Lupersol DDM
Lupersol Delta X
Lupersol DNF
Lupersol DSW
MEK peroxide
MEKPO
Mepox
Methyl ethyl ketone hydroperoxide
Methyl ethyl ketone peroxide
Methyl ethyl ketone peroxide (ACGIH)
Methylethylketonhydroperoxide
NCI-C55447
Permek G
Permek N
Quickset Extra
Quickset super
RCRA waste number U160
Sprayset MEKP
Superox 46-710
Thermacure
Skin and Eye Irritation and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
eye /rabbit | 3 mg | AIHAAP 19,205,1958 | |
eye /rabbit | 40% | VCVGK* -,529,1994 | |
skin /rabbit | 500 mg | AIHAAP 19,205,1958 |
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
mutation in microorganisms | /Salmonella typhimurium | 104 µg/plate/72H (-enzymatic activation step) | MUTAEX 15,495,2000 |
Tumorigenic Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
unreported route/mouse | lowest published toxic dose: 282 mg/kg | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors Blood: Lymphoma including Hodgkin's disease | RARSAM 3,193,1963 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/mouse | lethal concentration (50 percent kill): 170 ppm/4H | Lung, Thorax, or Respiration: Dyspnea | AIHAAP 19,205,1958 |
inhalation/mouse | lethal concentration (50 percent kill): 2500 mg/m3/4H | Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Cough | VCVGK* -,528,1994 |
inhalation/rat | lethal concentration (50 percent kill): 3600 mg/m3/4H | Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Cough | VCVGK* -,528,1994 |
inhalation/rat | lethal concentration (50 percent kill): 200 ppm/4H | Lung, Thorax, or Respiration: Dyspnea | AIHAAP 19,205,1958 |
intraperitoneal/mouse | lethal dose (50 percent kill): 200 mg/kg | VCVGK* -,528,1994 | |
intraperitoneal/rat | lowest published toxic dose: 90 mg/kg | Liver: Other changes Kidney, Ureter, and Bladder: Other changes Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | VCVGK* -,528,1994 |
intraperitoneal/rat | lethal dose (50 percent kill): 65 mg/kg | Behavioral: Muscle weakness Behavioral: Ataxia | AIHAAP 19,205,1958 |
oral/human | lowest published toxic dose: 480 mg/kg | Gastrointestinal: Changes in structure or function of esophagus Gastrointestinal: Nausea or vomiting Gastrointestinal: Other changes | NCPBBY Jan/Feb,1969 |
oral/man | lowest published toxic dose: 0.57 gm/kg | Gastrointestinal: Ulceration or bleeding from stomach Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases | JTCTDW 46,74,2008 |
oral/mouse | lethal dose (50 percent kill): 250 mg/kg | VCVGK* -,528,1994 | |
oral/rat | lethal dose (50 percent kill): 470 mg/kg | VCVGK* -,528,1994 | |
skin/rabbit | lowest published toxic dose: 2000 mg/kg | Skin: After topical application: Primary irritation | VCVGK* -,528,1994 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
intraperitoneal/rat | lowest published toxic dose: 273 mg/kg/7W- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | AIHAAP 19,205,1958 |
oral/rat | lowest published toxic dose: 2033 mg/kg/7W- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | AIHAAP 19,205,1958 |
skin/mouse | lowest published toxic dose: 141 mg/kg/4W- intermittent | Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | CRNGDP 25,431,2004 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-ceiling concentration 0.2 ppm | DTLVS* TLV/BEI,2013 |
TOXICOLOGY REVIEW | HUTOX* -,649,1996 |
Standards and Regulations
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYL ETHYL KETONE PEROXIDE-air | ceiling concentration 0.2 ppm | NIOSH* DHHS #92-100,1992 |
National Occupational Exposure Survey 1983 | Hazard Code 80105; Number of Industries 23; Total Number of Facilities 1879; Number of Occupations 31; Total Number of Employees Exposed 25827; Total Number of Female Employees Exposed 6514 | |
National Occupational Hazard Survey 1974 | Hazard Code 80105; Number of Industries 29; Total Number of Facilities 2226; Number of Occupations 31; Total Number of Employees Exposed 20053 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health