1,3-Butadiene, 2-chloro-

RTECS #

EI9625000

CAS #

126-99-8
See: NMAM or OSHA Methods

Updated

March 2018

Molecular Weight

88.54

Molecular Formula

C₄H₅Cl

Synonyms

2-Chloor-1,3-butadieen (Dutch)
2-Chlor-1,3-butadien (German)
2-Chloro-1,3-butadiene
2-Chloro-1,3-butadiene (OSHA)
2-Chlorobuta-1,3-diene
2-Cloro-1,3-butadiene (Italian)
beta-Chloroprene
beta-Chloroprene (ACGIH:OSHA)
Chlorobutadiene
Chloropreen (Dutch)
Chloropren (German, Polish)
Chloroprene
Cloroprene (Italian)

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
skin /rabbit	500 µL/24H	severe	NTIS** OTS0535986

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Cytogenetic Analysis	unreported route/human	1 mg/m³	MUREAV 147,301,1985
Cytogenetic Analysis	inhalation/rat	1960 µg/m³/16W	BZARAZ 27(6),102,1974
Cytogenetic Analysis	inhalation/mouse	320 µg/m³/4W-continuous	GTPZAB 20(3),31,1976
DNA Damage	inhalation/mouse	32 ppm/104W- intermittent	CBINA8 135-136,373,2001
Dominant Lethal Test	inhalation/rat	4 µg/L/48D- intermittent	TNICS* 13,56,1973
host-mediated assay	Salmonella typhimurium/mouse	375 mg/kg/4H	ZKMAAX 16,41,1976
micronucleus test	inhalation/mouse	1480 µg/m³/2H/2D-continuous	HYDXET 17,209,1986
morphological transform	embryo/hamster	125 mg/L	AETODY 1,241,1980
mutation in microorganisms	/Salmonella typhimurium	70 µmol/L (+enzymatic activation step)	NATUAS 255,641,1975
mutation in microorganisms	/Salmonella typhimurium	2 pph/4H (-enzymatic activation step)	ARTODN 41,249,1979
sex chromosome loss and nondisjunction	oral/Drosophila melanogaster	5700 µmol/L/3D- intermittent	35WYAM -,63,1976

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	4 mg/m³/24H (3-4D pregnant)	Reproductive: Effects on embryo or fetus: Fetal death	GTPZAB 19(3),30,1975
inhalation/rat	4 mg/m³/24H (11-12D pregnant)	Reproductive: Specific developmental abnormalities: Central nervous system	GTPZAB 19(3),30,1975
inhalation/rat	10 ppm/4H (3-20D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)	TXAPA9 44,81,1978
inhalation/rat	150 µg/m³/24H (19W male)	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)	EVHPAZ 17,85,1976
inhalation/rat	500 mg/m³/5H (17W prior to copulation)	Reproductive: Maternal effects: Menstrual cycle changes or disorders	BEBMAE 60(7),107,1965
inhalation/rat	500 mg/m³/5H (30W prior to copulation)	Reproductive: Maternal effects: Ovaries, fallopian tubes	BEBMAE 60(7),107,1965
inhalation/rat	0.15 mg/m³ (multigenerations)	Reproductive: Effects on embryo or fetus: Fetal death	VCVGH* -,505,1990
inhalation/rat	0.0038 gm/m³ (48D male)	Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)	TPKVAL 13,58,1973
oral/rat	9100 µg/kg (26W male)	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)	GISAAA 45(2),17,1980
oral/rat	1 mg/kg (11-12D pregnant)	Reproductive: Specific developmental abnormalities: Central nervous system	GTPZAB 19(3),30,1975
oral/rat	1 mg/kg (11-12D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	GTPZAB 19(7),30,1975
oral/rat	1 mg/kg (9-10D pregnant)	Reproductive: Other developmental abnormalities	GTPZAB 19(7),30,1975

Tumorigenic Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mouse	lowest published toxic concentration: 32 ppm/6H/2Y- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors Lung, Thorax, or Respiration: Tumors	NTPTR* NTP-TR-467,1998
inhalation/mouse	lowest published toxic concentration: 32 ppm/6H/104W - intermittent	Tumorigenic: Neoplastic by RTECS criteria Gastrointestinal: Tumors Tumorigenic: Increased incidence of tumors in susceptible strains	CBINA8 135-136,373,2001
inhalation/mouse	lowest published toxic concentration: 80 ppm/5H/104W - intermittent	Tumorigenic: Neoplastic by RTECS criteria Gastrointestinal: Tumors Tumorigenic: Increased incidence of tumors in susceptible strains	CBINA8 135-136,373,2001
inhalation/mouse	lowest published toxic concentration: 791.04 mg/kg/103W- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Lung, Thorax, or Respiration: Tumors	NTIS** PB99-123671
inhalation/mouse	lowest published toxic concentration: 1977.6 mg/kg/103W- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Skin and Appendages: Tumors Liver: Tumors	NTIS** PB99-123671
inhalation/rat	lowest published toxic concentration: 80 ppm/6H/2Y- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Olfaction: Tumors	NTPTR* NTP-TR-467,1998
inhalation/rat	lowest published toxic concentration: 988.9 mg/kg/103W- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Gastrointestinal: Tumors Kidney, Ureter, and Bladder: Bladder tumors	NTIS** PB99-123671
inhalation/rat	lowest published toxic concentration: 2060 mg/kg/103W- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Gastrointestinal: Tumors Endocrine: Thyroid tumors	NTIS** PB99-123671

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/cat	Lowest published lethal concentration: 1290 mg/m³/8H		JIHTAB 18,240,1936
inhalation/cat	Lowest published lethal concentration: 3500 mg/m³/2H		VCVGH* -,504,1990
inhalation/human	lowest published toxic concentration: 100 mg/kg/5M	Eye: Lacrimation Behavioral: Headache Gastrointestinal: Nausea or vomiting	VCVGH* -,505,1990
inhalation/mouse	lethal concentration (50 percent kill): 1600 mg/m³		VCVGH* -,504,1990
inhalation/mouse	Lowest published lethal concentration: 600 mg/m³/8H		VCVGH* -,504,1990
inhalation/mouse	lethal concentration (50 percent kill): 2300 mg/m³/2H		VCVGH* -,504,1990
inhalation/rabbit	Lowest published lethal concentration: 6000 mg/m³/2H		VCVGH* -,504,1990
inhalation/rabbit	Lowest published lethal concentration: 3870 mg/m³/8H		JIHTAB 18,240,1936
inhalation/rat	lethal concentration (50 percent kill): 11800 mg/m³/4H		85GMAT -,38,1982
inhalation/rat	lowest published toxic concentration: 17000 mg/kg/5H	Lung, Thorax, or Respiration: Acute pulmonary edema	VCVGH* -,504,1990
inhalation/rat	lethal concentration (50 percent kill): 300 mg/m³		VCVGH* -,504,1990
intravenous/rabbit	lowest published lethal dose: 96 mg/kg	Blood: Other changes Skin: After systemic exposure: Dermatitis, other	SBLEA2 44,63,1942
oral/mouse	lethal dose (50 percent kill): 146 mg/kg		85GMAT -,38,1982
oral/rat	lethal dose (50 percent kill): 450 mg/kg		85GMAT -,38,1982
subcutaneous/cat	lowest published lethal dose: 100 mg/kg		JIHTAB 18,240,1936
subcutaneous/mouse	lowest published lethal dose: 1 gm/kg	Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Dyspnea Lung, Thorax, or Respiration: Cyanosis	JIHTAB 18,240,1936
subcutaneous/pigeon	lowest published lethal dose: 13 gm/kg		JIHTAB 18,240,1936
subcutaneous/rat	lowest published lethal dose: 500 mg/kg	Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Dyspnea Lung, Thorax, or Respiration: Cyanosis	JIHTAB 18,240,1936
unreported route/mouse	lethal dose (50 percent kill): 146 mg/kg		VCVGH* -,504,1990
unreported route/rat	lethal dose (50 percent kill): 119 mg/kg		VCVGH* -,504,1990

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/hamster	lowest published toxic concentration: 162 ppm/6H/4W- intermittent	Liver: Hepatitis (hepatocellular necrosis), zonal Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	TXAPA9 46,375,1978
inhalation/hamster	lowest published toxic concentration: 50 ppm/6H/78W- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	INHTE5 10,443,1998
inhalation/mouse	lowest published toxic concentration: 3 ppm/5D- intermittent	Lung, Thorax, or Respiration: Other changes	TOXID9 -,207,2009
inhalation/mouse	lowest published toxic dose: 1260 mg/m³/14D- intermittent	Endocrine: Changes in thymus weight Immunological Including Allergic: Decrease in cellular immune response Immunological Including Allergic: Decrease in humoral immune response	ZYYZEW 3,125,1989
inhalation/mouse	lowest published toxic concentration: 200 mg/m³/24H/91D- continuous	Gastrointestinal: Ulceration or bleeding from large intestine Blood: Changes in spleen Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	JIHTAB 18,240,1936
inhalation/rat	lowest published toxic concentration: 161 ppm/6H/4W- intermittent	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	TXAPA9 46,375,1978
inhalation/rat	lowest published toxic concentration: 220 µg/m³/24H/60D- continuous	Brain and Coverings: Other degenerative changes Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases	GISAAA 29(9),13,1964
inhalation/rat	lowest published toxic concentration: 200 mg/m³/24H/91D- continuous	Brain and Coverings: Other degenerative changes Gastrointestinal: Ulceration or bleeding from large intestine Blood: Changes in spleen	JIHTAB 18,240,1936
inhalation/rat	lowest published toxic concentration: 50 ppm/6H/2Y- intermittent	Lung, Thorax, or Respiration: Changes in lung weight Skin and Appendages: Other: Hair Nutritional and Gross Metabolic: Weight loss or decreased weight gain	INHTE5 10,443,1998
inhalation/rat	lowest published toxic concentration: 32 ppm/6H/16D- intermittent	Olfaction: Other olfaction effects	NTPTR* NTP-TR-467,1998
inhalation/rat	lowest published toxic concentration: 0.039 gm/m³/48D- intermittent	Kidney, Ureter, and Bladder: Other changes in urine composition	TPKVAL 13,58,1973
intraperitoneal/rat	lowest published toxic dose: 168 mg/kg/21D- intermittent	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Liver: Other changes Blood: Other changes	WDZAEK 6,126,1992
oral/mouse	lowest published toxic dose: 63 mg/m³/21D- intermittent	Immunological Including Allergic: Decreased immune response	ZYYZEW 2,57,1988
oral/rat	lowest published toxic dose: 9100 µg/kg/26W- intermittent	Liver: Changes in liver weight Endocrine: Changes in spleen weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases	GISAAA 45(2),17,1980
oral/rat	lowest published toxic dose: 1680 mg/kg/3W- intermittent	Liver: Hepatitis (hepatocellular necrosis), diffuse Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)	ZYYZEW 9,283,1995
subcutaneous/mouse	lowest published toxic dose: 42 mg/kg/21D- intermittent	Immunological Including Allergic: Decreased immune response Biochemical: Metabolism (intermediary): Other proteins	ZYYZEW 2,57,1988

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 10 ppm (skin)	DTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Sufficient Evidence	IMEMDT 71,227,1999
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Inadequate Evidence	IMEMDT 19,131,1979
International Agency for Research on Cancer (IARC)	Cancer Review:Human Inadequate Evidence	IMEMDT 19,131,1979
International Agency for Research on Cancer (IARC)	Cancer Review:Human Inadequate Evidence	IMEMDT 71,227,1999
International Agency for Research on Cancer (IARC)	Cancer Review:Group 2B	IMEMDT 71,227,1999
TOXICOLOGY REVIEW		CTOXAO 13,153,1978
TOXICOLOGY REVIEW		CBINA8 135-136,81,2001
TOXICOLOGY REVIEW		CBINA8 135-136,27,2001
TOXICOLOGY REVIEW		MUREAV 543,201,2003
TOXICOLOGY REVIEW		MUREAV 567,109,2004
TOXICOLOGY REVIEW		MUREAV 567,347,2004
TOXICOLOGY REVIEW		HETOEA 25,413,2006
TOXICOLOGY REVIEW		REPTED 25,192,2008
TOXICOLOGY REVIEW		MUREAV 566,49,2004
TOXICOLOGY REVIEW		MUREAV 682,94,2009
TOXICOLOGY REVIEW		NTAPM* -,629,1995
TOXICOLOGY REVIEW		MUREAV 751,49,2012
TOXICOLOGY REVIEW		TOLED5 204,148,2011

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 25 ppm (90 mg/m³) (skin)	DTLVS* 3,54,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 10 ppm (36 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 5 ppm (18 mg/m³);KZW 20 ppm (72 mg/m³), skin, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 10 ppm (37 mg/m³), Skin, MAR2002
Occupational Exposure Limit-DENMARK	ceiling concentration 1 ppm (3.6 mg/m³), skin, carc, MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 1 ppm (3.7 mg/m³), short term exposure limit 5 ppm (18 mg/m³), NOV2011
Occupational Exposure Limit-FRANCE	VME 10 ppm (36 mg/m³), C2 Carcinogen, FEB2006
Occupational Exposure Limit-HUNGARY	time-weighted average 18 mg/m³, short term exposure limit 72 mg/m³, SEP2000
Occupational Exposure Limit-ICELAND	short term exposure limit 1 ppm (3.6 mg/m³), skin, NOV2011
Occupational Exposure Limit-JAPAN	2B carc, MAY2012
Occupational Exposure Limit-KOREA	time-weighted average 10 ppm (35 mg/m³), skin, 2006
Occupational Exposure Limit-MEXICO	time-weighted average 10 ppm (45 mg/m³) (skin), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 10 ppm (36 mg/m³), skin, JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 1 ppm (3.6 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 10 ppm (36 mg/m³), JUL2005
Occupational Exposure Limit-POLAND	MAC(time-weighted average) 2 mg/m³, short term exposure limit, 16 mg/m³, JAN1999
Occupational Exposure Limit-RUSSIA	short term exposure limit 2 mg/m³, JUN2003
Occupational Exposure Limit-SWEDEN	time-weighted average 1 ppm (3.5 mg/m³);short term exposure limit 5 ppm (18 mg/m³), Skin, JUN2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 5 ppm (18 mg/m³), carc 2, skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 18 mg/m³, Skin, 2003
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 25 ppm (90 mg/m³) (skin)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 25 ppm (90 mg/m³) (skin)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 25 ppm (90 mg/m³) (skin)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 25 ppm (90 mg/m³) (skin)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO beta-CHLOROPRENE-air	Carcinogen ceiling concentration 1 ppm	NIOSH* DHHS #95-121,1995
National Occupational Exposure Survey 1983	Hazard Code 18260; Number of Industries 17; Total Number of Facilities 1864; Number of Occupations 21; Total Number of Employees Exposed 17750; Total Number of Female Employees Exposed 654
National Occupational Hazard Survey 1974	Hazard Code 18260; Number of Industries 39; Total Number of Facilities 3538; Number of Occupations 26; Total Number of Employees Exposed 43712

Status in Federal Agencies

Organization	Reference
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE; Sperm morphology-rat
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE	FEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (inhal);clear evidence:mouse,rat
NIOSH Analytical Method, 1994: beta-Chloroprene, 1002
NIOSH CURRENT INTELLIGENCE BULLETIN 1, 1975
NTP 14th Report on Carcinogens,2016:Reasonably anticipated to be human carcinogen
On EPA IRIS database
OSHA ANALYTICAL METHOD #112

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health