Boric acid, disodium salt

RTECS #

ED4588000

CAS #

1330-43-4; 1332-28-1
See: NMAM or OSHA Methods

Updated

September 2018

Molecular Weight

201.22

Molecular Formula

B₄O₇·2Na

Synonyms

Anhydrous borax
Borates, tetra, sodium salt, anhydrous (ACGIH)
Borates, tetra, sodium salts (anhydrous)
Borax glass
Disodium tetraborate
FR 28
Fused borax
Rasorite 65
Sodium biborate
Sodium boron oxide
Sodium tetraborate
Sodium tetraborate (Na2B4O7)

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
oral/rat	16750 µg/kg (30D male)	Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands	EVHPAZ 13,59,1976

Acute Toxicity Data and References

Route/Organism	Dose	Reference
intraperitoneal/mouse	lethal dose (50 percent kill): 2817 mg/kg	VCVN1* -,193,1988
oral/mouse	lethal dose (50 percent kill): 1060 mg/kg	VCVN1* -,193,1988
oral/rat	lethal dose (50 percent kill): 1200 mg/kg	VCVN1* -,193,1988

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
oral/rabbit	lowest published toxic dose: 22680 mg/kg/12W- intermittent	Blood: Luekopenia Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood: Changes in erythrocyte (RBC) count	VCVN1* -,195,1988
oral/rat	lowest published toxic dose: 1312.5 mg/kg/70D- continuous	Nutritional and Gross Metabolic: Weight loss or decreased weight gain Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct	VCVN1* -,195,1988
oral/rat	lowest published toxic dose: 283.5 mg/kg/70D- continuous	Nutritional and Gross Metabolic: Weight loss or decreased weight gain Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct	VCVN1* -,195,1988
oral/rat	lowest published toxic dose: 26 gm/kg/14W- continuous	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases Biochemical: Metabolism (intermediary): Xanthine, purine or nucleotides including urate	TOLED5 10,219,1982

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 2 mg/m³;short term exposure limit 6 mg/m³ (inhal)	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		TOLED5 258,115,2016

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	RED Completed	RBREV* -,91,1998
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 1 mg/m³, JUL2008
Occupational Exposure Limit-BELGIUM	time-weighted average 2 mg/m³, short term exposure limit 6 mg/m³, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 1 mg/m³, MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 0.5 mg(B)/m³, NOV2011
Occupational Exposure Limit-FRANCE	VME 1 mg/m³, FEB2006
Occupational Exposure Limit-ICELAND	time-weighted average 1 mg/m³, NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 1 mg/m³, 2006
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 1 mg/m³, JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 1 mg/m³, JAN1999
Occupational Exposure Limit-PERU	time-weighted average 1 mg/m³, JUL2005
Occupational Exposure Limit-RUSSIA	short term exposure limit 2 mg/m³, JUN2003
Occupational Exposure Limit-SWITZERLAND	MAK-week 1 mg/m³, inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 1 mg/m³, 2003
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 1 mg/m³, OCT2007

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Occupational Exposure Survey 1983	Hazard Code M3899; Number of Industries 87; Total Number of Facilities 6225; Number of Occupations 57; Total Number of Employees Exposed 78116; Total Number of Female Employees Exposed 15080
National Occupational Hazard Survey 1974	Hazard Code B0085; Number of Industries 34; Total Number of Facilities 1170; Number of Occupations 27; Total Number of Employees Exposed 5513
National Occupational Hazard Survey 1974	Hazard Code M3899; Number of Industries 1; Total Number of Facilities 5; Number of Occupations 1; Total Number of Employees Exposed 101

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health