4-Biphenylamine

RTECS #

DU8925000

CAS #

92-67-1
See: NMAM or OSHA Methods

Updated

March 2019

Molecular Weight

169.24

Molecular Formula

C₁₂H₁₁N

Synonyms

(1,1'-Biphenyl)-4-amine
4-Aminobifenyl (Czech)
4-Aminobiphenyl
4-Aminodifenil (Spanish)
4-Aminodiphenyl
4-Aminodiphenyl (ACGIH:OSHA)
4-Bifenylamin (Czech)
Biphenylamine
p-Aminobiphenyl
p-Aminodiphenyl
Paraaminodiphenyl
p-Biphenylamine
p-Phenylaniline
Xenylamin (Czech)
Xenylamine

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
body fluid assay	Salmonella typhimurium/rat	250 µmol/kg	TXCYAC 16,113,1980
body fluid assay	Salmonella typhimurium/Dog	10 mg/kg	CNREA8 37,1757,1977
Cytogenetic Analysis	intraperitoneal/mouse	25 mg/kg	MUREAV 268,255,1992
Cytogenetic Analysis	lymphocyte/mouse	50 mg/L	MUREAV 320,69,1994
Cytogenetic Analysis	intraperitoneal/rat	10 mg/kg/72H	NULSAK 23,36,1980
DNA adduct	/Escherichia coli	30 µmol/L	MUREAV 89,95,1981
DNA adduct	oral/Dog	5 mg/kg	CNREA8 48,6336,1988
DNA adduct	skin/mouse	8.5 mg/kg/24H	TOXID9 72(Supp 1),336,2003
DNA adduct	oral/mouse	80 mg/kg	TOSCF2 73,279,2003
DNA adduct	unreported route/mouse	120 mg/kg	CBINA8 146,51,2003
DNA adduct	oral/rat	10 mg/kg	TOXID9 90,161,2006
DNA adduct	skin/mouse	10 mg/kg	JNCIEQ 95,1227,2003
DNA adduct	intraperitoneal/mouse	558.492 µg/kg/8D- intermittent	MOCAE8 42,193,2005
DNA Damage	intraperitoneal/mouse	1692.4 µg/kg/8D- intermittent	MOCAE8 42,193,2005
DNA Damage	other cell types/human	0.06 mmol/plate	EMMUEG 38,1,2001
DNA Damage	other cell types/rat	0.5 mmol/L/20H	TXCYAC 179,115,2002
DNA Damage	other cell types/human	0.125 mmol/L/20H	TXCYAC 179,115,2002
DNA Damage	other cell types/human	60 µmol/L	EMMUEG 38,1,2001
DNA Damage	liver/human	37.5 µmol/L/24H	TXCYAC 322,69,2014
DNA Damage	lymphocyte/human	500 µmol/L/2H	TOSCF2 72,283,2003
DNA Damage	lung/hamster	300 µmol/L/2H	BBRCA9 72,732,1976
DNA Damage	liver/rat	30 µmol/L	SinJF# 26OCT1982
DNA repair	/Bacillus subtilis	200 µg/disc	MUREAV 97,1,1982
DNA repair	/Escherichia coli	250 mg/L	JJIND8 62,873,1979
gene conversion and mitotic recombination	/Saccharomyes cerevisiae	2 pph	JJIND8 62,901,1979
host-mediated assay	Salmonella typhimurium/rat	1 mmol/kg	MUREAV 93,317,1982
host-mediated assay	Escherichia coli/mouse	67 mg/kg	MUREAV 272,161,1992
micronucleus test	intraperitoneal/mouse	28 mg/kg/24H-continuous	MUREAV 216,321,1989
micronucleus test	oral/mouse	50 mg/kg/48H- intermittent	MUREAV 389,3,1997
morphological transform	embryo/mouse	10 mg/L	JNCIAM 52,1167,1974
morphological transform	oral/rat	100 mg/kg	CNREA8 40,1157,1980
morphological transform	embryo/rat	10 mg/L	JNCIAM 51,799,1973
morphological transform	kidney/hamster	80 µg/L	BJCAAI 37,873,1978
morphological transform	embryo/hamster	5 mg/L	NCIMAV 58,243,1981
morphological transform	fibroblast/mouse	0.1 mg/L/21D (-enzymatic activation step)	EMMUEG 35,300,2000
mutation in mammalian somatic cells	lung/hamster	5 mg/L	CNREA8 43,5194,1983
mutation in mammalian somatic cells	lymphocyte/mouse	5 mg/L	MUREAV 125,291,1984
mutation in mammalian somatic cells	oral/mouse	75 mg/kg	MUREAV 400,245,1998
mutation in mammalian somatic cells	fibroblast/human	60 mg/L	MUREAV 121,71,1983
mutation in microorganisms	/Salmonella typhimurium	2 µg/plate (-enzymatic activation step)	ENMUDM 5(Suppl 1),3,1983
mutation in microorganisms	/Escherichia coli	900 µg/L (+enzymatic activation step)	CNREA8 39,682,1979
mutation in microorganisms	/Salmonella typhimurium	3 µg/plate (+enzymatic activation step)	TOSCF2 56,351,2000
mutation in microorganisms	/Salmonella typhimurium	10 µg/plate/20M (+enzymatic activation step)	MUREAV 515,15,2002
mutation in microorganisms	/Salmonella typhimurium	1 nmol/plate/20M	EMMUEG 38,268,2001
mutation in microorganisms	/Salmonella typhimurium	600 µmol/L/3H	TCMUD8 23,47,2003
mutation in microorganisms	/Escherichia coli	30 nmol/plate (+enzymatic activation step)	MUTAEX 20,199,2005
mutation in microorganisms	/Escherichia coli	37.5 nmol/plate/48H (+enzymatic activation step)	MUTAEX 20,199,2005
other mutation test systems	intraperitoneal/mouse	100 mg/kg	MUREAV 268,255,1992
other mutation test systems	lymphocyte/mouse	50 mg/L	MUREAV 320,69,1994
phage inhibition capacity	/Escherichia coli	25 mg/L	CNREA8 41,532,1981
sister chromatid exchange	intraperitoneal/hamster	50 mg/kg	MUREAV 113,33,1983
sister chromatid exchange	oral/hamster	50 mg/kg	MUREAV 113,33,1983
specific locus test	oral/Drosophila melanogaster	500 µmol/L	MUREAV 242,169,1990
specific locus test	intraperitoneal/mouse	0.3 µmol/2D- intermittent	MUTAEX 21,29,2006
specific locus test	ovary/hamster	5 mg/L/9D	EMMUEG 16,260,1990
specific locus test	other cell types/mouse	50 µmol/L/4H (+enzymatic activation step)	MUTAEX 31,287,2016
Unscheduled DNA Synthesis	liver/human	100 µg/L	MUREAV 206,91,1988
Unscheduled DNA Synthesis	fibroblast/human	800 µg/L	TXCYAC 21,151,1981
Unscheduled DNA Synthesis	oral/mouse	200 mg/kg	ENMUDM 6,474,1984
Unscheduled DNA Synthesis	liver/rabbit	500 µmol/L	CNREA8 43,3120,1983
Unscheduled DNA Synthesis	oral/rat	200 mg/kg	ENMUDM 6,474,1984
Unscheduled DNA Synthesis	liver/rat	3 µmol/L	MUREAV 216,101,1989

Tumorigenic Data and References

Route/Organism	Dose	Effect	Reference
intraperitoneal/mouse	lowest published toxic dose: 85 µg/kg	Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors	CALEDQ 185,13,2002
oral/Dog	toxic dose: 5580 mg/kg/4Y- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors Kidney, Ureter, and Bladder: Bladder tumors	NEOLA4 15,3,1968
oral/Dog	toxic dose: 8200 mg/kg/90W- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, and Bladder: Bladder tumors	JAMAAP 172,1611,1960
oral/Dog	toxic dose: 8200 mg/kg/2Y- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, and Bladder: Bladder tumors	IMSUAI 27,25,1958
oral/Dog	toxic dose: 9600 mg/kg/3Y- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, and Bladder: Bladder tumors	IMSUAI 27,25,1958
oral/Dog	toxic dose: 8400 mg/kg/2Y- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, and Bladder: Bladder tumors	IMSUAI 27,25,1958
oral/Dog	toxic dose: 14 gm/kg/3Y- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, and Bladder: Bladder tumors	IMSUAI 27,25,1958
oral/mouse	toxic dose: 5460 µg/kg	Tumorigenic: Carcinogenic by RTECS criteria Kidney, Ureter, and Bladder: Bladder tumors Blood: Tumors	EJCODS 21,865,1985
oral/mouse	lowest published toxic dose: 1520 mg/kg/39W- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Liver: Tumors Kidney, Ureter, and Bladder: Bladder tumors	BJCAAI 19,297,1965
oral/rat	lowest published toxic dose: 5 gm/kg/52W- continuous	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Skin and Appendages: Tumors	ARZNAD 12,270,1962
subcutaneous/mouse	lowest published toxic dose: 216 mg/kg/3D- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors	JNCIAM 41,403,1968
subcutaneous/rat	toxic dose: 5000 mg/kg/1W- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Gastrointestinal: Tumors Liver: Tumors	BMBUAQ 14,141,1958
subcutaneous/rat	lowest published toxic dose: 4560 mg/kg/44W- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Liver: Tumors Kidney, Ureter, and Bladder: Kidney tumors	NATUAS 175,1131,1955

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Human, liver tumor	Inhibitor Concentration Low: 100 µmol/L/24H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TXCYAC 322,69,2014
intraperitoneal/mouse	lowest published toxic dose: 20 mg/kg/24H	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases	TXCYAC 373,30,2016
intraperitoneal/mouse	lowest published lethal dose: 250 mg/kg	Behavioral: Convulsions or effect on seizure threshold Behavioral: Ataxia Lung, Thorax, or Respiration: Dyspnea	CBCCT* 6,54,1954
intraperitoneal/rat	lowest published toxic dose: 10 µg/kg	Blood: Other changes	BECTA6 67,649,2001
oral/Dog	lowest published lethal dose: 25 mg/kg	Blood: Methemoglobinemia- Carboxhemoglobinemia	SCIEAS 167,992,1970
oral/Dog	lethal dose (50 percent kill): 25 mg/kg		ENTOX* -,92,2005
oral/mouse	lethal dose (50 percent kill): 205 mg/kg		EJCODS 21,865,1985
oral/mouse	lowest published toxic dose: 120 mg/kg	Liver: Other changes	TOXID9 66,10,2002
oral/rabbit	lethal dose (50 percent kill): 690 mg/kg	Behavioral: Coma Lung, Thorax, or Respiration: Dyspnea Nutritional and Gross Metabolic: Weight loss or decreased weight gain	JIHTAB 29,1,1947
oral/rat	lethal dose (50 percent kill): 500 mg/kg	Behavioral: Coma Lung, Thorax, or Respiration: Dyspnea Nutritional and Gross Metabolic: Weight loss or decreased weight gain	JIHTAB 29,1,1947
oral/rat	lethal dose (50 percent kill): 500 mg/kg		ENTOX* -,92,2005
oral/rat	lowest published toxic dose: 0.1 µg/kg	Blood: Other changes	BECTA6 67,649,2001
skin/mouse	lowest published toxic dose: 16.9 mg/kg	Liver: Other changes Blood: Methemoglobinemia- Carboxhemoglobinemia Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases	TXAPA9 181,32,2002

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
intraperitoneal/mouse	lowest published toxic dose: 16755 µg/kg/8D- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	MOCAE8 42,193,2005

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Control as low as possible	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Confirmed human carcinogen	DTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)	Cancer Review:Human Limited Evidence	IMEMDT 1,74,1972
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Sufficient Evidence	IMEMDT 1,74,1972
International Agency for Research on Cancer (IARC)	Cancer Review:Human Sufficient Evidence	IMEMDT 28,151,1982
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Sufficient Evidence	IMEMDT 99,100,2010
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Sufficient Evidence	IMEMDT 100F,50,2012
International Agency for Research on Cancer (IARC)	Cancer Review:Human Sufficient Evidence	IMEMDT 99,100,2010
International Agency for Research on Cancer (IARC)	Cancer Review:Human Sufficient Evidence	IMEMDT 100F,50,2012
International Agency for Research on Cancer (IARC)	Cancer Review:Group 1	IMSUDL 7,91,1987
International Agency for Research on Cancer (IARC)	Cancer Review:Group 1	IMEMDT 100F,50,2012
International Agency for Research on Cancer (IARC)	Cancer Review:Group 1	IMEMDT 99,100,2010
TOXICOLOGY REVIEW		KHZHAZ 12(2),85,1976
TOXICOLOGY REVIEW		ADCSAJ 13,271,1970
TOXICOLOGY REVIEW		BLFSBY 24,253,1983
TOXICOLOGY REVIEW		ARPTDI 43,485,2003
TOXICOLOGY REVIEW		TOLED5 134,39,2002
TOXICOLOGY REVIEW		MUREAV 567,347,2004
TOXICOLOGY REVIEW		TXAPA9 197,144,2004
TOXICOLOGY REVIEW		MUTAEX 14,301,1999
TOXICOLOGY REVIEW		TCMUD8 23(Suppl 1),187,2003
TOXICOLOGY REVIEW		MUREAV 588,88,2005
TOXICOLOGY REVIEW		MUREAV 612,58,2006
TOXICOLOGY REVIEW		MUREAV 567,427,2004
TOXICOLOGY REVIEW		MUREAV 567,447,2004
TOXICOLOGY REVIEW		ENTOX* -,92,2005
TOXICOLOGY REVIEW		FCTOD7 44,1699,2006
TOXICOLOGY REVIEW		MUREAV 627,10,2007
TOXICOLOGY REVIEW		MUREAV 584,1,2005
TOXICOLOGY REVIEW		TOPADD 33,517,2005
TOXICOLOGY REVIEW		MUREAV 659,68,2008
TOXICOLOGY REVIEW		HUTOX* -,649,1996
TOXICOLOGY REVIEW		MUREAV 574,92,2005
TOXICOLOGY REVIEW		MUREAV 590,1,2005
TOXICOLOGY REVIEW		MUTAEX 23,1,2008
TOXICOLOGY REVIEW		MUREAV 579,6,2005
TOXICOLOGY REVIEW		MUREAV 705,107,2010
TOXICOLOGY REVIEW		MUREAV 751,49,2012
TOXICOLOGY REVIEW		MUREAV 752,99,2013
TOXICOLOGY REVIEW		MUREAV 769,34,2014
TOXICOLOGY REVIEW		MUREAV 767,1,2016
TOXICOLOGY REVIEW		MUREAV 768,27,2016
TOXICOLOGY REVIEW		MUTAEX 31,117,2016
TOXICOLOGY REVIEW		MUREAV 802,1,2016
TOXICOLOGY REVIEW		FCTOD7 94,93,2016
TOXICOLOGY REVIEW		EMMUEG 57,499,2016
TOXICOLOGY REVIEW		RTOPDW 56,67,2010
TOXICOLOGY REVIEW		MUTAEX 33,179,2018

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD	skin-HUMAN CARCINOGEN, NO ASSIGNED time-weighted average	DTLVS* 3,10,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	Prohibited, Carcinogen, JUL2008
Occupational Exposure Limit-BELGIUM	Skin, MAR2002
Occupational Exposure Limit-FRANCE	VME 0.001 ppm (0.007 mg/m³), C1 Carcinogen, FEB2006
Occupational Exposure Limit-HUNGARY	ceiling concentration 10 mg/m³, Carcinogen, SEP2000
Occupational Exposure Limit-JAPAN	1 carc, MAY2012
Occupational Exposure Limit-KOREA	carcinogen, skin, 2006
Occupational Exposure Limit-NEW ZEALAND	carcinogen, skin, JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 0.1 mg/m³, JAN1999
Occupational Exposure Limit-SWEDEN	Group A Carcinogen, JUN2005
Occupational Exposure Limit-SWITZERLAND	carc 1, JAN2011
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	see Code of Federal Regulations (CFR) 29,1926.1111	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	see Code of Federal Regulations (CFR) 29,1910.1011	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	see Code of Federal Regulations (CFR) 29,1915.1011	CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA)-cancer suspect agent		CFRGBR 29,1910.1011,1987

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 4-AMINODIPHENYL-air	Carcinogen use 29 Code of Federal Regulations (CFR) 1910.1011	NIOSH* DHHS #92-100,1992

Status in Federal Agencies

Organization	Reference
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus; E coli polA without S9
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Positive: Body fluid assay; Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo; Host-mediated assay
EPA GENETOX PROGRAM 1988, Positive: E coli polA with S9; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: In vitro UDS in rat liver; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive: SHE-clonal assay; Cell transform.-mouse embryo
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 14th Report on Carcinogens,2016:Known to be a human carcinogen
OSHA ANALYTICAL METHOD #93

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health