2-Benzimidazolecarbamic acid, 1-(butylcarbamoyl)-, methyl ester

RTECS #

DD6475000

CAS #

17804-35-2
See: NMAM or OSHA Methods

Updated

March 2019

Molecular Weight

290.36

Molecular Formula

C₁₄H₁₈N₄O₃

Synonyms

1-(Butylcarbamoyl)-2-benzimidazolecarbamic acid, methyl ester
1-(Butylcarbamoyl)-2-benzimidazol-methylcarbamat (German)
1-(N-Butylcarbamoyl)-2-(methoxy-carboxamido)-benzimidazol (German)
Agrocit
BBC
BC 6597
Benlate
Benlate 50
Benlate 50 W
Benomyl
Benomyl (ACGIH:OSHA)
Benomyl 50W
Benomyl-Imex
Carbamic acid, (1-((butylamino)carbonyl)-1H-benzimidazol-2-yl)-, methyl ester (9CI)
Chinoin-fundazol
D 1991
Du Pont 1991
Fundazol
Fungicide D-1991
Fungochrom
MBC
NS 02
NS 02 (fungicide)
Tersan 1991
Uzgen

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
skin /man	0.1%	mild	LANCAO 2,1252,1980

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Cytogenetic Analysis	liver/human	100 µmol/L	MUREAV 26,177,1974
Cytogenetic Analysis	HeLa cell/human	100 µmol/L	MUREAV 26,177,1974
Cytogenetic Analysis	lymphocyte/human	10 mg/L	CYGEDX 17(1),29,1983
Cytogenetic Analysis	intraperitoneal/rat	1 gm/kg	MUREAV 26,177,1974
Cytogenetic Analysis	oral/mouse	1 gm/kg	MUREAV 300,15,1993
Cytogenetic Analysis	lung/hamster	100 µmol/L	MUREAV 26,177,1974
Cytogenetic Analysis	oral/mouse	1680 mg/kg/2W- intermittent	ARTODN 77,712,2003
DNA Damage	lymphocyte/human	3.5 mg/L/48H	MUREAV 607,160,2006
DNA Damage	other cell types/human	0.006 mmol/L/48H	MUTAEX 28,393,2013
DNA Damage	other cell types/human	50 µmol/L	RTOPDW 55,188,2009
DNA inhibition	oral/mouse	375 mg/kg	FCTOD7 28,701,1990
DNA repair	/Salmonella typhimurium	250 µg/disc	JPFCD2 21,319,1986
gene conversion and mitotic recombination	/Aspergillus nidulans	250 ppb	NATUAS 226,771,1970
micronucleus test	lymphocyte/human	10 mg/L	MUREAV 388,27,1997
micronucleus test	oral/rat	3500 mg/kg/10W-continuous	EMMUEG 16,32,1990
micronucleus test	liver/rat	500 µg/L	MUREAV 324,59,1994
micronucleus test	intraperitoneal/mouse	500 mg/kg/24H	NTIS** PB84-138973
micronucleus test	oral/mouse	2500 mg/kg	MUREAV 310,143,1994
micronucleus test	other cell types/mouse	10 mg/L	JNCIAM 56,357,1976
micronucleus test	ovary/hamster	34400 nmol/L	MUREAV 224,517,1989
micronucleus test	other cell types/human	1.2 mg/L/24H	RTOPDW 59,28,2011
micronucleus test	ovary/hamster	2.27 µmol/L/24H	MUTAEX 28,417,2013
morphological transform	embryo/hamster	2 mg/L	MUREAV 343,7,1995
mutation in mammalian somatic cells	lymphocyte/mouse	15 mg/L	NTIS** PB84-138973
mutation in microorganisms	/Salmonella typhimurium	125 µg/L (+enzymatic activation step)	MUREAV 40,379,1976
mutation in microorganisms	/Aspergillus nidulans	250 µg/L (-enzymatic activation step)	MUREAV 91,115,1981
mutation in microorganisms	/Escherichia coli	125 µg/L (-enzymatic activation step)	MUREAV 40,379,1976
mutation in microorganisms	/Bacillus subtilis	5000 ppm (-enzymatic activation step)	MUREAV 53,209,1978
mutation in microorganisms	/Other microorganisms	5 mg/L (-enzymatic activation step)	MUREAV 21,119,1973
mutation in microorganisms	/Saccharomyes cerevisiae	50 ppm (-enzymatic activation step)	RSTUDV 6,161,1976
other mutation test systems	lymphocyte/human	2 mg/L	EMMUEG 16,32,1990
sex chromosome loss and nondisjunction	/Saccharomyes cerevisiae	123 ppm	ANYAA9 407,186,1983
sex chromosome loss and nondisjunction	/Aspergillus nidulans	200 µg/L	EVHPAZ 31,81,1979
sex chromosome loss and nondisjunction	ovary/hamster	34400 nmol/L	MUREAV 224,517,1989
sex chromosome loss and nondisjunction	lymphocyte/human	1 mg/L	MUREAV 121,139,1983
sex chromosome loss and nondisjunction	oral/mouse	1 gm/kg	MUREAV 300,15,1993
sister chromatid exchange	oral/mouse	3360 mg/kg/4W- intermittent	ARTODN 77,712,2003
sister chromatid exchange	ovary/hamster	375 mg/L	NTIS** PB84-138973
sister chromatid exchange	lymphocyte/human	250 µg/L	EMMUEG 16,32,1990

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
oral/rat	3500 µg/kg (70D male)	Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)	TXCYAC 28,103,1983
oral/rat	936 mg/kg (7-21D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Eye, ear	CEYRDM 10,601,1991
oral/rat	250 mg/kg (12D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Other developmental abnormalities	BEXBAN 83,247,1977
oral/rat	1250 mg/kg (5D male)	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct	JTEHD6 13,53,1984
oral/rat	625 mg/kg (7-17D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Central nervous system	TXAPA9 62,44,1982
oral/rat	156 mg/kg (7-16D pregnant)	Reproductive: Specific developmental abnormalities: Musculoskeletal system	TXAPA9 62,44,1982
oral/rat	85 gm/kg (multigenerations)	Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)	ATSUDG 4,459,1980
oral/mouse	250 mg/kg (11D pregnant)	Reproductive: Effects on embryo or fetus: Fetal death	JHEMA2 24,295,1980
oral/mouse	1100 mg/kg (7-17D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)	TXAPA9 62,44,1982
oral/mouse	1100 mg/kg (7-17D pregnant)	Reproductive: Specific developmental abnormalities: Musculoskeletal system Reproductive: Specific developmental abnormalities: Urogenital system	TXAPA9 62,44,1982
oral/mouse	2200 mg/kg (7-17D pregnant)	Reproductive: Effects on embryo or fetus: Fetal death Reproductive: Specific developmental abnormalities: Body wall	TXAPA9 62,44,1982
oral/mouse	500 mg/kg (13D pregnant)	Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Musculoskeletal system	JHEMA2 24,295,1980
oral/mouse	1 gm/kg (8-12D pregnant)	Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	JTEHD6 10,541,1982
oral/rat	2800 mg/kg (28D male/28D prior to copulation)	Reproductive: Specific developmental abnormalities: Urogenital system	JTEHF8 67,1501,2004
parenteral/rat	250 mg/kg (10D pregnant)	Reproductive: Effects on embryo or fetus: Fetal death Reproductive: Specific developmental abnormalities: Central nervous system	40YJAX -,127,1979
unreported route/rat	250 mg/kg (12D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Other developmental abnormalities	GISAAA 41(12),32,1976

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Human, leukemia cells	Inhibitor Concentration Low: 1.2 mg/L/24H	In Vitro Toxicity Studies: Cell proliferation: DNA incorporation, mitotic index etc.	RTOPDW 59,28,2011
In Vitro/Human, lung	Inhibitor Concentration (50 percent kill): 44.2 µmol/L/24H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	FCTOD7 98,100,2016
In Vitro/Human, lung	Inhibitor Concentration (50 percent kill): 7.2 µmol/L/48H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	FCTOD7 98,100,2016
In Vitro/Human, lung	Inhibitor Concentration Low: 15.6 µmol/L/24H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	FCTOD7 98,100,2016
In Vitro/Human, lung	Inhibitor Concentration Low: 3.9 µmol/L/48H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	FCTOD7 98,100,2016
In Vitro/Human, lung	Inhibitor Concentration Low: 2 µmol/L/24H	In Vitro Toxicity Studies: Other assays	FCTOD7 98,100,2016
In Vitro/Human, lung	Inhibitor Concentration Low: 2 µmol/L/48H	Nutritional and Gross Metabolic: Changes in: Ca	FCTOD7 98,100,2016
inhalation/rat	lethal concentration (50 percent kill): >2 gm/m³/4H		PEMNDP 9,59,1991
oral/rat	lowest published toxic dose: 400 mg/kg	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct Related to Chronic Data: Changes in testicular weight	REPTED 6,491,1992
oral/rat	lethal dose (50 percent kill): >10 gm/kg		ENTOX* -,248,2005
oral/wild bird	lethal dose (50 percent kill): 100 mg/kg		TXAPA9 21,315,1972
skin/rabbit	lethal dose (50 percent kill): >10 gm/kg		PEMNDP 9,59,1991
skin/rat	lethal dose (50 percent kill): >1 gm/kg		WRPCA2 9,119,1970
Tank with water/Shrimp	lethal concentration (50 percent kill): 10 mg/L/96H		TIVIEQ 34,105,1996
Tank with water/Shrimp	lowest published toxic concentration: 1 mg/L/11D	Behavioral: Sleep Behavioral: Food intake (animal) Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	TIVIEQ 34,105,1996
unreported route/mammal (species unspecified)	lethal dose (50 percent kill): 10 gm/kg		GISAAA 41(8),82,1976
unreported route/rat	lethal dose (50 percent kill): 9920 mg/kg		EQSSDX 3,618,1975

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	lowest published toxic concentration: 200 mg/m³/6H/14W- intermittent	Olfaction: Other olfaction effects Nutritional and Gross Metabolic: Weight loss or decreased weight gain	FAATDF 12,333,1989
oral/Dog	lowest published toxic dose: 1800 mg/kg/90D- intermittent	Endocrine: Changes in adrenal weight Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood: Changes in leukocyte (WBC) count	BECTA6 41,704,1988
oral/guinea pig	lowest published toxic dose: 33750 mg/kg/60D- intermittent	Immunological Including Allergic: Decreased immune response	KHZDAN 21,52,1978
oral/mouse	lowest published toxic dose: 163800 mg/kg/104W- continuous	Liver: Tumors	HBPTO* 1,814,2001
oral/mouse	lowest published toxic dose: 250 mg/kg/5D- intermittent	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)	ARTODN 77,712,2003
oral/mouse	lowest published toxic dose: 1800 mg/kg/15D- continuous	Liver: Changes in liver weight Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Peptidases	BECTA6 42,301,1989
oral/rat	lowest published toxic dose: 300 mg/kg/3D- intermittent	Liver: Changes in liver weight	TXAPA9 205,11,2005
oral/rat	lowest published toxic dose: 3000 mg/kg/3D- intermittent	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight Related to Chronic Data: Changes in uterine weight	TXAPA9 205,11,2005
oral/rat	lowest published toxic dose: 1000 mg/kg/10D- intermittent	Related to Chronic Data: Changes in prostate weight	TXAPA9 205,11,2005
oral/rat	lowest published toxic dose: 3000 mg/kg/10D- intermittent	Liver: Changes in liver weight Related to Chronic Data: Changes in prostate weight	TXAPA9 205,11,2005
oral/rat	lowest published toxic dose: 10000 mg/kg/10D- intermittent	Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Changes in prostate weight	TXAPA9 205,11,2005
oral/rat	lowest published toxic dose: 900 mg/kg/3D- intermittent	Gastrointestinal: Changes in structure or function of salivary glands	TXAPA9 205,11,2005
oral/rat	lowest published toxic dose: 3000 mg/kg/3D- intermittent	Kidney, Ureter, and Bladder: Changes in kidney weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Changes in uterine weight	TXAPA9 205,11,2005
oral/rat	lowest published toxic dose: 1000 mg/kg/10D- intermittent	Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands	TXAPA9 205,11,2005
oral/rat	lowest published toxic dose: 3000 mg/kg/10D- intermittent	Liver: Changes in liver weight	TXAPA9 205,11,2005
oral/rat	lowest published toxic dose: 2400 mg/kg/8D- intermittent	Gastrointestinal: Changes in structure or function of salivary glands	TXAPA9 205,11,2005
oral/rat	lowest published toxic dose: 3000 mg/kg/3D- intermittent	Gastrointestinal: Hypermotility, diarrhea	TXAPA9 205,11,2005
oral/rat	lowest published toxic dose: 3420 mg/kg/76D- intermittent	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct Related to Chronic Data: Changes in testicular weight	JTEHD6 25,285,1988
oral/rat	lowest published toxic dose: 42 gm/kg/30D- continuous	Brain and Coverings: Changes in brain weight Liver: Changes in liver weight Blood: Changes in other cell count (unspecified)	APTOD9 19,A97,1980
oral/rat	lowest published toxic dose: 2520 mg/kg/7D- continuous	Liver: Other changes	AEHLAU 47,314,1992
oral/rat	lowest published toxic dose: 3 gm/kg/15D- continuous	Liver: Changes in liver weight Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Peptidases	BECTA6 42,301,1989

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 1 mg/m³ (inhal, sen)	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Confirmed animal carcinogen	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		RREVAH 63,1,1976
TOXICOLOGY REVIEW		MUREAV 557,109,2004
TOXICOLOGY REVIEW		TOLED5 140-141,53,2003
TOXICOLOGY REVIEW		MUREAV 562,77,2004
TOXICOLOGY REVIEW		MUTAEX 21,93,2006
TOXICOLOGY REVIEW		MUTAEX 20,389,2005
TOXICOLOGY REVIEW		ENTOX* -,248,2005
TOXICOLOGY REVIEW		MUREAV 584,1,2005
TOXICOLOGY REVIEW		JTEHD6 7,1,2004
TOXICOLOGY REVIEW		MUREAV 672,10,2009
TOXICOLOGY REVIEW		MUREAV 672,17,2009
TOXICOLOGY REVIEW		HTOPA* 1,501,2002
TOXICOLOGY REVIEW		FCTOD7 46,813,2008
TOXICOLOGY REVIEW		MUTAEX 21,343,2006
TOXICOLOGY REVIEW		MUTAEX 26,199,2011
TOXICOLOGY REVIEW		MUREAV 721,27,2011
TOXICOLOGY REVIEW		TOLED5 201,152,2011
TOXICOLOGY REVIEW		MUREAV 763,181,2015
TOXICOLOGY REVIEW		MUREAV 783,66,2015
TOXICOLOGY REVIEW		TXCYAC 307,136,2013
TOXICOLOGY REVIEW		MUREAV 786-788,14,2015
TOXICOLOGY REVIEW		TOLED5 230,146,2014
TOXICOLOGY REVIEW		TXAPA9 268,157,2013
TOXICOLOGY REVIEW		MUREAV 802,1,2016
TOXICOLOGY REVIEW		FCTOD7 83,300,2015
TOXICOLOGY REVIEW		MUREAV 770,12,2016
TOXICOLOGY REVIEW		NETEEC 52,25,2015
TOXICOLOGY REVIEW		MUREAV 770,183,2016
TOXICOLOGY REVIEW		EMMUEG 57,87,2016
TOXICOLOGY REVIEW		RTOPDW 61,251,2011

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	Supported	RBREV* -,89,1998
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 0.84 ppm (10 mg/m³), JUL2008
Occupational Exposure Limit-BELGIUM	time-weighted average 0.84 ppm (10 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 5 mg/m³, carc, MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 0.8 ppm (9.6 mg/m³), short term exposure limit 2.4 ppm (29 mg/m³), NOV2011
Occupational Exposure Limit-FRANCE	VME 0.8 ppm (10 mg/m³), FEB2006
Occupational Exposure Limit-ICELAND	time-weighted average 5 mg/m³, NOV2011
Occupational Exposure Limit-JAPAN	s2 sen, MAY2012
Occupational Exposure Limit-KOREA	time-weighted average 0.8 ppm (10 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 0.8 ppm (10 mg/m³);short term exposure limit 1.3 ppm (15 mg/m³), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 0.84 ppm (10 mg/m³), JAN2002
Occupational Exposure Limit-PERU	time-weighted average 0.84 ppm (10 mg/m³), JUL2005
Occupational Exposure Limit-RUSSIA	short term exposure limit 0.2 mg/m³, JUN2003
Occupational Exposure Limit-SWITZERLAND	MAK-week 0.8 ppm (10 mg/m³), inhal, sen, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 10 mg/m³, 2003
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 15 mg/m³, total dust	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 5 mg/m³, respirable fraction	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 15 mg/m³, total dust	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 5 mg/m³, respirable fraction	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 15 mg/m³, total dust	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 5 mg/m³, respirable fraction	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 15 mg/m³, total dust	CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 5 mg/m³, respirable fraction	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Occupational Exposure Survey 1983	Hazard Code X2223; Number of Industries 4; Total Number of Facilities 361; Number of Occupations 2; Total Number of Employees Exposed 4189; Total Number of Female Employees Exposed 378

Status in Federal Agencies

Organization	Reference
EPA GENETOX PROGRAM 1988, Inconclusive: TRP reversion
EPA GENETOX PROGRAM 1988, Negative: Aspergillus-recombination; Host-mediated assay
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion
EPA GENETOX PROGRAM 1988, Positive: Aspergillus-aneuploidy; TRP reversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health