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2-Benzimidazolecarbamic acid, 1-(butylcarbamoyl)-, methyl ester

RTECS #
DD6475000
CAS #
17804-35-2
See: NMAM or OSHA Methods
Updated
March 2019
Molecular Weight
290.36
Molecular Formula
C14H18N4O3
Synonyms
1-(Butylcarbamoyl)-2-benzimidazolecarbamic acid, methyl ester
1-(Butylcarbamoyl)-2-benzimidazol-methylcarbamat (German)
1-(N-Butylcarbamoyl)-2-(methoxy-carboxamido)-benzimidazol (German)
Agrocit
BBC
BC 6597
Benlate
Benlate 50
Benlate 50 W
Benomyl
Benomyl (ACGIH:OSHA)
Benomyl 50W
Benomyl-Imex
Carbamic acid, (1-((butylamino)carbonyl)-1H-benzimidazol-2-yl)-, methyl ester (9CI)
Chinoin-fundazol
D 1991
Du Pont 1991
Fundazol
Fungicide D-1991
Fungochrom
MBC
NS 02
NS 02 (fungicide)
Tersan 1991
Uzgen

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /man 0.1% mildLANCAO 2,1252,1980

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisliver/human100 µmol/LMUREAV 26,177,1974
Cytogenetic AnalysisHeLa cell/human100 µmol/LMUREAV 26,177,1974
Cytogenetic Analysislymphocyte/human10 mg/LCYGEDX 17(1),29,1983
Cytogenetic Analysisintraperitoneal/rat1 gm/kgMUREAV 26,177,1974
Cytogenetic Analysisoral/mouse1 gm/kgMUREAV 300,15,1993
Cytogenetic Analysislung/hamster100 µmol/LMUREAV 26,177,1974
Cytogenetic Analysisoral/mouse1680 mg/kg/2W- intermittentARTODN 77,712,2003
DNA Damagelymphocyte/human3.5 mg/L/48HMUREAV 607,160,2006
DNA Damageother cell types/human0.006 mmol/L/48HMUTAEX 28,393,2013
DNA Damageother cell types/human50 µmol/LRTOPDW 55,188,2009
DNA inhibitionoral/mouse375 mg/kgFCTOD7 28,701,1990
DNA repair/Salmonella typhimurium250 µg/discJPFCD2 21,319,1986
gene conversion and mitotic recombination/Aspergillus nidulans250 ppbNATUAS 226,771,1970
micronucleus testlymphocyte/human10 mg/LMUREAV 388,27,1997
micronucleus testoral/rat3500 mg/kg/10W-continuousEMMUEG 16,32,1990
micronucleus testliver/rat500 µg/LMUREAV 324,59,1994
micronucleus testintraperitoneal/mouse500 mg/kg/24HNTIS** PB84-138973
micronucleus testoral/mouse2500 mg/kgMUREAV 310,143,1994
micronucleus testother cell types/mouse10 mg/LJNCIAM 56,357,1976
micronucleus testovary/hamster34400 nmol/LMUREAV 224,517,1989
micronucleus testother cell types/human1.2 mg/L/24HRTOPDW 59,28,2011
micronucleus testovary/hamster2.27 µmol/L/24HMUTAEX 28,417,2013
morphological transformembryo/hamster2 mg/LMUREAV 343,7,1995
mutation in mammalian somatic cellslymphocyte/mouse15 mg/LNTIS** PB84-138973
mutation in microorganisms/Salmonella typhimurium125 µg/L (+enzymatic activation step)MUREAV 40,379,1976
mutation in microorganisms/Aspergillus nidulans250 µg/L (-enzymatic activation step)MUREAV 91,115,1981
mutation in microorganisms/Escherichia coli125 µg/L (-enzymatic activation step)MUREAV 40,379,1976
mutation in microorganisms/Bacillus subtilis5000 ppm (-enzymatic activation step)MUREAV 53,209,1978
mutation in microorganisms/Other microorganisms5 mg/L (-enzymatic activation step)MUREAV 21,119,1973
mutation in microorganisms/Saccharomyes cerevisiae50 ppm (-enzymatic activation step)RSTUDV 6,161,1976
other mutation test systemslymphocyte/human2 mg/LEMMUEG 16,32,1990
sex chromosome loss and nondisjunction/Saccharomyes cerevisiae123 ppmANYAA9 407,186,1983
sex chromosome loss and nondisjunction/Aspergillus nidulans200 µg/LEVHPAZ 31,81,1979
sex chromosome loss and nondisjunctionovary/hamster34400 nmol/LMUREAV 224,517,1989
sex chromosome loss and nondisjunctionlymphocyte/human1 mg/LMUREAV 121,139,1983
sex chromosome loss and nondisjunctionoral/mouse1 gm/kgMUREAV 300,15,1993
sister chromatid exchangeoral/mouse3360 mg/kg/4W- intermittentARTODN 77,712,2003
sister chromatid exchangeovary/hamster375 mg/LNTIS** PB84-138973
sister chromatid exchangelymphocyte/human250 µg/LEMMUEG 16,32,1990

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 3500 µg/kg (70D male)Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)TXCYAC 28,103,1983
oral/rat 936 mg/kg (7-21D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Eye, ear
CEYRDM 10,601,1991
oral/rat 250 mg/kg (12D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Other developmental abnormalities
BEXBAN 83,247,1977
oral/rat 1250 mg/kg (5D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
JTEHD6 13,53,1984
oral/rat 625 mg/kg (7-17D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Central nervous system
TXAPA9 62,44,1982
oral/rat 156 mg/kg (7-16D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemTXAPA9 62,44,1982
oral/rat 85 gm/kg (multigenerations)Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)ATSUDG 4,459,1980
oral/mouse 250 mg/kg (11D pregnant)Reproductive: Effects on embryo or fetus: Fetal deathJHEMA2 24,295,1980
oral/mouse 1100 mg/kg (7-17D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
TXAPA9 62,44,1982
oral/mouse 1100 mg/kg (7-17D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Urogenital system
TXAPA9 62,44,1982
oral/mouse 2200 mg/kg (7-17D pregnant)Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Body wall
TXAPA9 62,44,1982
oral/mouse 500 mg/kg (13D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Musculoskeletal system
JHEMA2 24,295,1980
oral/mouse 1 gm/kg (8-12D pregnant)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
JTEHD6 10,541,1982
oral/rat 2800 mg/kg (28D male/28D prior to copulation)Reproductive: Specific developmental abnormalities: Urogenital systemJTEHF8 67,1501,2004
parenteral/rat 250 mg/kg (10D pregnant)Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Central nervous system
40YJAX -,127,1979
unreported route/rat 250 mg/kg (12D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Other developmental abnormalities
GISAAA 41(12),32,1976

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, leukemia cells Inhibitor Concentration Low: 1.2 mg/L/24HIn Vitro Toxicity Studies: Cell proliferation: DNA incorporation, mitotic index etc.RTOPDW 59,28,2011
In Vitro/Human, lung Inhibitor Concentration (50 percent kill): 44.2 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.FCTOD7 98,100,2016
In Vitro/Human, lung Inhibitor Concentration (50 percent kill): 7.2 µmol/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.FCTOD7 98,100,2016
In Vitro/Human, lung Inhibitor Concentration Low: 15.6 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.FCTOD7 98,100,2016
In Vitro/Human, lung Inhibitor Concentration Low: 3.9 µmol/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.FCTOD7 98,100,2016
In Vitro/Human, lung Inhibitor Concentration Low: 2 µmol/L/24HIn Vitro Toxicity Studies: Other assaysFCTOD7 98,100,2016
In Vitro/Human, lung Inhibitor Concentration Low: 2 µmol/L/48HNutritional and Gross Metabolic: Changes in: CaFCTOD7 98,100,2016
inhalation/rat lethal concentration (50 percent kill): >2 gm/m3/4HPEMNDP 9,59,1991
oral/rat lowest published toxic dose: 400 mg/kgReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Changes in testicular weight
REPTED 6,491,1992
oral/rat lethal dose (50 percent kill): >10 gm/kgENTOX* -,248,2005
oral/wild bird lethal dose (50 percent kill): 100 mg/kgTXAPA9 21,315,1972
skin/rabbit lethal dose (50 percent kill): >10 gm/kgPEMNDP 9,59,1991
skin/rat lethal dose (50 percent kill): >1 gm/kgWRPCA2 9,119,1970
Tank with water/Shrimp lethal concentration (50 percent kill): 10 mg/L/96HTIVIEQ 34,105,1996
Tank with water/Shrimp lowest published toxic concentration: 1 mg/L/11DBehavioral: Sleep

Behavioral: Food intake (animal)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TIVIEQ 34,105,1996
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 10 gm/kgGISAAA 41(8),82,1976
unreported route/rat lethal dose (50 percent kill): 9920 mg/kgEQSSDX 3,618,1975

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 200 mg/m3/6H/14W- intermittentOlfaction: Other olfaction effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAATDF 12,333,1989
oral/Dog lowest published toxic dose: 1800 mg/kg/90D- intermittentEndocrine: Changes in adrenal weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in leukocyte (WBC) count
BECTA6 41,704,1988
oral/guinea pig lowest published toxic dose: 33750 mg/kg/60D- intermittentImmunological Including Allergic: Decreased immune responseKHZDAN 21,52,1978
oral/mouse lowest published toxic dose: 163800 mg/kg/104W- continuousLiver: TumorsHBPTO* 1,814,2001
oral/mouse lowest published toxic dose: 250 mg/kg/5D- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)ARTODN 77,712,2003
oral/mouse lowest published toxic dose: 1800 mg/kg/15D- continuousLiver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Peptidases
BECTA6 42,301,1989
oral/rat lowest published toxic dose: 300 mg/kg/3D- intermittentLiver: Changes in liver weightTXAPA9 205,11,2005
oral/rat lowest published toxic dose: 3000 mg/kg/3D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Related to Chronic Data: Changes in uterine weight
TXAPA9 205,11,2005
oral/rat lowest published toxic dose: 1000 mg/kg/10D- intermittentRelated to Chronic Data: Changes in prostate weightTXAPA9 205,11,2005
oral/rat lowest published toxic dose: 3000 mg/kg/10D- intermittentLiver: Changes in liver weight

Related to Chronic Data: Changes in prostate weight
TXAPA9 205,11,2005
oral/rat lowest published toxic dose: 10000 mg/kg/10D- intermittentLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in prostate weight
TXAPA9 205,11,2005
oral/rat lowest published toxic dose: 900 mg/kg/3D- intermittentGastrointestinal: Changes in structure or function of salivary glandsTXAPA9 205,11,2005
oral/rat lowest published toxic dose: 3000 mg/kg/3D- intermittentKidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in uterine weight
TXAPA9 205,11,2005
oral/rat lowest published toxic dose: 1000 mg/kg/10D- intermittentReproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glandsTXAPA9 205,11,2005
oral/rat lowest published toxic dose: 3000 mg/kg/10D- intermittentLiver: Changes in liver weightTXAPA9 205,11,2005
oral/rat lowest published toxic dose: 2400 mg/kg/8D- intermittentGastrointestinal: Changes in structure or function of salivary glandsTXAPA9 205,11,2005
oral/rat lowest published toxic dose: 3000 mg/kg/3D- intermittentGastrointestinal: Hypermotility, diarrheaTXAPA9 205,11,2005
oral/rat lowest published toxic dose: 3420 mg/kg/76D- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Changes in testicular weight
JTEHD6 25,285,1988
oral/rat lowest published toxic dose: 42 gm/kg/30D- continuousBrain and Coverings: Changes in brain weight

Liver: Changes in liver weight

Blood: Changes in other cell count (unspecified)
APTOD9 19,A97,1980
oral/rat lowest published toxic dose: 2520 mg/kg/7D- continuousLiver: Other changesAEHLAU 47,314,1992
oral/rat lowest published toxic dose: 3 gm/kg/15D- continuousLiver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Peptidases
BECTA6 42,301,1989

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 1 mg/m3 (inhal, sen)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWRREVAH 63,1,1976
TOXICOLOGY REVIEWMUREAV 557,109,2004
TOXICOLOGY REVIEWTOLED5 140-141,53,2003
TOXICOLOGY REVIEWMUREAV 562,77,2004
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWMUTAEX 20,389,2005
TOXICOLOGY REVIEWENTOX* -,248,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWJTEHD6 7,1,2004
TOXICOLOGY REVIEWMUREAV 672,10,2009
TOXICOLOGY REVIEWMUREAV 672,17,2009
TOXICOLOGY REVIEWHTOPA* 1,501,2002
TOXICOLOGY REVIEWFCTOD7 46,813,2008
TOXICOLOGY REVIEWMUTAEX 21,343,2006
TOXICOLOGY REVIEWMUTAEX 26,199,2011
TOXICOLOGY REVIEWMUREAV 721,27,2011
TOXICOLOGY REVIEWTOLED5 201,152,2011
TOXICOLOGY REVIEWMUREAV 763,181,2015
TOXICOLOGY REVIEWMUREAV 783,66,2015
TOXICOLOGY REVIEWTXCYAC 307,136,2013
TOXICOLOGY REVIEWMUREAV 786-788,14,2015
TOXICOLOGY REVIEWTOLED5 230,146,2014
TOXICOLOGY REVIEWTXAPA9 268,157,2013
TOXICOLOGY REVIEWMUREAV 802,1,2016
TOXICOLOGY REVIEWFCTOD7 83,300,2015
TOXICOLOGY REVIEWMUREAV 770,12,2016
TOXICOLOGY REVIEWNETEEC 52,25,2015
TOXICOLOGY REVIEWMUREAV 770,183,2016
TOXICOLOGY REVIEWEMMUEG 57,87,2016
TOXICOLOGY REVIEWRTOPDW 61,251,2011

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,89,1998
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.84 ppm (10 mg/m3), JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.84 ppm (10 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 5 mg/m3, carc, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.8 ppm (9.6 mg/m3), short term exposure limit 2.4 ppm (29 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 0.8 ppm (10 mg/m3), FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 5 mg/m3, NOV2011
Occupational Exposure Limit-JAPANs2 sen, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 0.8 ppm (10 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.8 ppm (10 mg/m3);short term exposure limit 1.3 ppm (15 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.84 ppm (10 mg/m3), JAN2002
Occupational Exposure Limit-PERUtime-weighted average 0.84 ppm (10 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.2 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 0.8 ppm (10 mg/m3), inhal, sen, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 10 mg/m3, 2003
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 15 mg/m3, total dustCFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 5 mg/m3, respirable fractionCFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 15 mg/m3, total dustCFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 5 mg/m3, respirable fractionCFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 15 mg/m3, total dustCFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 5 mg/m3, respirable fractionCFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 15 mg/m3, total dustCFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 5 mg/m3, respirable fractionCFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X2223; Number of Industries 4; Total Number of Facilities 361; Number of Occupations 2; Total Number of Employees Exposed 4189; Total Number of Female Employees Exposed 378

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: TRP reversion
EPA GENETOX PROGRAM 1988, Negative: Aspergillus-recombination; Host-mediated assay
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion
EPA GENETOX PROGRAM 1988, Positive: Aspergillus-aneuploidy; TRP reversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
Page last reviewed: November 16, 2018