Benzene, 2,4-diisocyanato-1-methyl-
RTECS #
CZ6300000
CAS #
Updated
March 2019
Molecular Weight
174.17
Molecular Formula
C9H6N2O2
Synonyms
2,4-Diisocyanato-1-methylbenzene (9CI)
2,4-Diisocyanatotoluene
2,4-TDI
2,4-Toluenediisocyanate
2,4-Tolylenediisocyanate
4-Methyl-phenylene diisocyanate
4-Methyl-phenylene isocyanate
Cresorcinol diisocyanate
Desmodur T80
Di-isocyanate de toluylene (French)
Di-iso-cyanatoluene
Diisocyanat-toluol (German)
Hylene T
Isocyanic acid, 4-methyl-m-phenylene ester
Mondur TD
Mondur TD-80
Mondur TDS
Nacconate IOO
NCI-C50533
RCRA waste number U223
TDI
TDI (OSHA)
TDI-80
Tolueen-diisocyanaat (Dutch)
Toluen-disocianato (Italian)
Toluene 2,4-diisocyanate
Toluene diisocyanate
Toluene-2,4-diisocyanate
Toluene-2,4-diisocyanate (ACGIH:OSHA)
Toluilenodwuizocyjanian (Polish)
Toluylene-2,4-diisocyanate
Tolyene 2,4-diisocyanate
Tolylene-2,4-diisocyanate
Tuluylendiisocyanat (German)
2,4-Diisocyanatotoluene
2,4-TDI
2,4-Toluenediisocyanate
2,4-Tolylenediisocyanate
4-Methyl-phenylene diisocyanate
4-Methyl-phenylene isocyanate
Cresorcinol diisocyanate
Desmodur T80
Di-isocyanate de toluylene (French)
Di-iso-cyanatoluene
Diisocyanat-toluol (German)
Hylene T
Isocyanic acid, 4-methyl-m-phenylene ester
Mondur TD
Mondur TD-80
Mondur TDS
Nacconate IOO
NCI-C50533
RCRA waste number U223
TDI
TDI (OSHA)
TDI-80
Tolueen-diisocyanaat (Dutch)
Toluen-disocianato (Italian)
Toluene 2,4-diisocyanate
Toluene diisocyanate
Toluene-2,4-diisocyanate
Toluene-2,4-diisocyanate (ACGIH:OSHA)
Toluilenodwuizocyjanian (Polish)
Toluylene-2,4-diisocyanate
Tolyene 2,4-diisocyanate
Tolylene-2,4-diisocyanate
Tuluylendiisocyanat (German)
Skin and Eye Irritation and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
eye /rabbit | 100 mg | severe | EJTXAZ 9,41,1976 |
skin /rabbit | 500 mg open irritation test | severe | UCDS** 3/8/1973 |
skin /rabbit | 500 mg/24H | moderate | EJTXAZ 9,41,1976 |
skin /rat | 12 mg/8H | moderate | TOLED5 199,364,2010 |
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
micronucleus test | inhalation/rat | 0.05 ppm/6H/4W | CRTXB2 31,737,2001 |
morphological transform | fibroblast/mouse | 0.2 mg/L/21D (-enzymatic activation step) | EMMUEG 37,231,2001 |
mutation in microorganisms | /Salmonella typhimurium | 0.033 mg/plate (+enzymatic activation step) | CRTXB2 31,737,2001 |
mutation in microorganisms | /Salmonella typhimurium | 100 µg/plate (-enzymatic activation step) | ENMUDM 9(Suppl 9),1,1987 |
sister chromatid exchange | ovary/hamster | 300 mg/L | EMMUEG 13,133,1989 |
specific locus test | lymphocyte/mouse | 75 mg/L | EMMUEG 17,196,1991 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
In Vitro/Human, leukemia cells | Inhibitor Concentration Low: >10 µmol/L | In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc. | TOLED5 239,32,2015 |
In Vitro/Human, leukemia cells | Inhibitor Concentration (50 percent kill): 1762 µmol/L/24H | In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc. | TOLED5 239,32,2015 |
In Vitro/Human, lung | Inhibitor Concentration (20 percent kill): 0.15 mmol/L | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 30,274,2015 |
In Vitro/Human, lung | Inhibitor Concentration (50 percent kill): 207 gm/L/3H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 27,174,2013 |
In Vitro/Human, lung | Inhibitor Concentration (50 percent kill): 100 gm/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 27,174,2013 |
In Vitro/Human, lung | Inhibitor Concentration (50 percent kill): 63 gm/L/24H | In Vitro Toxicity Studies: Other assays | TIVIEQ 27,174,2013 |
In Vitro/Human, lung tumor | Inhibitor Concentration (50 percent kill): 7.3 gm/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 27,174,2013 |
In Vitro/Human, monocyte | Inhibitor Concentration (20 percent kill): 500 µmol/L/2H | In Vitro Toxicity Studies: Other assays | TOLED5 199,51,2010 |
In Vitro/Mouse, fibroblast | Inhibitor Concentration (50 percent kill): 12 gm/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 27,174,2013 |
inhalation/guinea pig | lethal concentration (50 percent kill): 13 ppm/4H | Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance Lung, Thorax, or Respiration: Pleural effusion | AIHAAP 23,447,1962 |
inhalation/human | lowest published toxic concentration: 20 ppb/2Y | Lung, Thorax, or Respiration: Cough Lung, Thorax, or Respiration: Sputum | PRSMA4 63,372,1970 |
inhalation/human | lowest published toxic concentration: 500 ppb | Olfaction: Other olfaction effects Lung, Thorax, or Respiration: Other changes | JOCMA7 1,448,1959 |
inhalation/human | lowest published toxic concentration: 80 ppb | Olfaction: Other olfaction effects Eye: Other eye effects Lung, Thorax, or Respiration: Other changes | ATXKA8 19,364,1962 |
inhalation/mouse | lethal concentration (50 percent kill): 10 ppm/4H | Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance | AIHAAP 23,447,1962 |
inhalation/mouse | lethal concentration (50 percent kill): 10 ppm/4H | ENTOX* -,204,2005 | |
inhalation/rabbit | lethal concentration (50 percent kill): 11 ppm/4H | Behavioral: Excitement Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Changes in structure or function of salivary glands | AIHAAP 23,447,1962 |
inhalation/rat | lowest published toxic concentration: 0.004 gm/m3/4H | Liver: Hepatitis (hepatocellular necrosis), zonal | TPKVAL 9,37,1967 |
inhalation/rat | lethal concentration (50 percent kill): 14 ppm/4H | ENTOX* -,204,2005 | |
inhalation/rat | lethal concentration (50 percent kill): 14 ppm/4H | Eye: Lacrimation Behavioral: Excitement Lung, Thorax, or Respiration: Dyspnea | AIHAAP 23,447,1962 |
inhalation/woman | lowest published toxic concentration: 300 ppt/8H/5D | Lung, Thorax, or Respiration: Respiratory obstruction | LANCAO 1,756,1980 |
intravenous/mouse | lethal dose (50 percent kill): 56 mg/kg | CSLNX* NX#07807 | |
oral/rat | lethal dose (50 percent kill): 5800 mg/kg | Gastrointestinal: Other changes | AMIHAB 15,324,1957 |
oral/rat | lethal dose (30 percent kill): 6.17 gm/kg | ENTOX* -,204,2005 | |
oral/wild bird | lethal dose (50 percent kill): 100 mg/kg | AECTCV 12,355,1983 | |
skin/rabbit | lethal dose (50 percent kill): >16 mL/kg | UCDS** 3/8/1973 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/guinea pig | lowest published toxic concentration: 3100 ppb/4H/5D- intermittent | Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Blood: Changes in leukocyte (WBC) count | EXLRDA 11,145,1986 |
inhalation/mouse | lowest published toxic concentration: 990 ppb/6H/14D- intermittent | Olfaction: Other olfaction effects | JJATDK 15,207,1995 |
inhalation/rabbit | lowest published toxic dose: 1500 ppb/71D- intermittent | Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | AMIHAB 15,324,1957 |
inhalation/rabbit | lowest published toxic concentration: 1500 ppb/6H/79D- intermittent | Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi | AMIHAB 15,324,1957 |
inhalation/rat | lowest published toxic concentration: 204 µg/m3/24H/84D- continuous | Behavioral: Muscle contraction or spasticity Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Metabolism (intermediary): Lipids including transport | GISAAA 28(6),8,1963 |
inhalation/rat | lowest published toxic concentration: 102 ppb/24H/7D- continuous | Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi | JJATDK 14,369,1994 |
inhalation/rat | lowest published toxic concentration: 26 ppm/6H/5W- intermittent | Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTIS** OTS0570993 |
intradermal/mouse | lowest published toxic dose: 500 mg/kg/3D- intermittent | Skin: After topical application: Cutaneous sensitization (experimental) | EXPDE* 15,322,2006 |
intratracheal/rat | lowest published toxic dose: 48.84 µL/kg/21D- intermittent | Immunological Including Allergic: Other immediate (humoral): uticaria, allergic rhinitis, serum sickness (multiple organ involvement) Biochemical: Metabolism (intermediary): Histamines (including liberation not immunochemical in origin) | JPHSC* 109,606,2009 |
multiple/mouse | lowest published toxic dose: 0.3 pph/3D- intermittent | Lung, Thorax, or Respiration: Bronchiolar constriction, including asthma Lung, Thorax, or Respiration: Acute pulmonary edema Lung, Thorax, or Respiration: Changes in lung weight | TOXID9 72,43,2003 |
oral/guinea pig | lowest published toxic dose: 70 mg/kg/7D- intermittent | Immunological Including Allergic: Other immediate (humoral): uticaria, allergic rhinitis, serum sickness (multiple organ involvement) Biochemical: Metabolism (intermediary): Histamines (including liberation not immunochemical in origin) | ACPSI* 24,251,2003 |
oral/rat | lowest published toxic dose: 15 gm/kg/10D- intermittent | Gastrointestinal: Other changes Liver: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | AMIHAB 15,324,1957 |
skin/mouse | lowest published toxic dose: 1 pph/3D- intermittent | Immunological Including Allergic: Increased immune response Biochemical: Metabolism (intermediary): Other proteins Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TXCYAC 261,103,2009 |
skin/mouse | lowest published toxic dose: 90 mg/kg/3D- intermittent | Skin: After topical application: Dermatitis, allergic Biochemical: Metabolism (intermediary): Other proteins Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TOLED5 190,231,2009 |
skin/mouse | lowest published toxic dose: 7.2 mg/kg/6D- intermittent | Skin: After topical application: Cutaneous sensitization (experimental) | FCTOD7 48,1704,2010 |
skin/mouse | lowest published toxic dose: 12 mg/kg/8D- intermittent | Blood: Other changes Skin: After topical application: Cutaneous sensitization (experimental) | TXCYAC 279,85,2011 |
skin/mouse | lowest published toxic dose: 30 mg/kg/3D- intermittent | Blood: Other changes Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TOLED5 280,133,2017 |
skin/mouse | lowest published toxic dose: 15 mg/kg/3D- intermittent | Skin: After topical application: Cutaneous sensitization (experimental) Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TXAPA9 184,46,2002 |
skin/mouse | lowest published toxic dose: 800 mg/kg/4D- intermittent | Immunological Including Allergic: Increased immune response Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | EJPHAZ 446,195,2002 |
skin/mouse | lowest published toxic dose: 240 mg/kg/28D- intermittent | Immunological Including Allergic: Increase in humoral response | TOSCF2 94,108,2006 |
skin/mouse | lowest published toxic dose: 0.03 mL/kg/3D- intermittent | Skin: After topical application: Cutaneous sensitization (experimental) | TOLED5 177,1,2008 |
skin/mouse | lowest published toxic dose: 1.8 ul/kg/3D- intermittent | Skin: After topical application: Cutaneous sensitization (experimental) | TOLED5 180,1,2008 |
skin/mouse | lowest published toxic dose: 18 ul/kg/17D- intermittent | Skin: After topical application: Cutaneous sensitization (experimental) | TOLED5 180,1,2008 |
skin/mouse | lowest published toxic dose: 18.2 ul/kg/31D- intermittent | Skin: After topical application: Cutaneous sensitization (experimental) Immunological Including Allergic: Increased immune response | TOLED5 180,1,2008 |
skin/mouse | lowest published toxic dose: 1.7 mg/kg/17D- intermittent | Immunological Including Allergic: Increase in cellular immune response Immunological Including Allergic: Increase in humoral response | TOLED5 181,163,2008 |
skin/mouse | lowest published toxic dose: 90 mg/kg/3D- intermittent | Immunological Including Allergic: Increase in humoral response Biochemical: Metabolism (intermediary): Other proteins Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TXCYAC 250,116,2008 |
skin/mouse | lowest published toxic dose: 4.8 mg/kg/8D- intermittent | Lung, Thorax, or Respiration: Other changes Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TOXID9 -,11,2009 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.005 ppm;short term exposure limit 0.02 ppm (sen) | DTLVS* TLV/BEI,2013 |
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
International Agency for Research on Cancer (IARC) | Cancer Review:Animal Sufficient Evidence | IMEMDT 39,287,1986 |
International Agency for Research on Cancer (IARC) | Cancer Review:Animal Sufficient Evidence | IMEMDT 71,865,1999 |
International Agency for Research on Cancer (IARC) | Cancer Review:Human No Adequate Data | IMEMDT 39,287,1986 |
International Agency for Research on Cancer (IARC) | Cancer Review:Human Inadequate Evidence | IMEMDT 71,865,1999 |
International Agency for Research on Cancer (IARC) | Cancer Review:Group 2B | IMEMDT 71,865,1999 |
TOXICOLOGY REVIEW | AOHYA3 17,143,1974 | |
TOXICOLOGY REVIEW | JJOMDZ 15,808,1973 | |
TOXICOLOGY REVIEW | CMTVAS 10(3),49,1973 | |
TOXICOLOGY REVIEW | CRTXB2 31,737,2001 | |
TOXICOLOGY REVIEW | MUREAV 539,77,2003 | |
TOXICOLOGY REVIEW | MUREAV 567,227,2004 | |
TOXICOLOGY REVIEW | DIMON* 46,551,2000 | |
TOXICOLOGY REVIEW | ENTOX* -,204,2005 | |
TOXICOLOGY REVIEW | MUREAV 584,1,2005 | |
TOXICOLOGY REVIEW | MUREAV 681,93,2009 | |
TOXICOLOGY REVIEW | MUREAV 802,1,2016 | |
TOXICOLOGY REVIEW | RTOPDW 56,54,2010 | |
TOXICOLOGY REVIEW | RTOPDW 61,1,2011 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Mine Safety and Health Administration (MSHA) STANDARD | air-ceiling concentration 0.02 ppm (0.14 mg/m3) | DTLVS* 3,260,1971 |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
Occupational Exposure Limit-ARAB Republic of Egypt | time-weighted average 0.02 ppm (0.14 mg/m3), JAN1993 | |
Occupational Exposure Limit-AUSTRALIA | time-weighted average 0.02 mg(NCO)/m3, short term exposure limit 0.07 mg(NCO)/m3, JUL2008 | |
Occupational Exposure Limit-AUSTRIA | MAK-TMW 0.005 ppm (0.035 mg/m3);KZW 0.02 ppm (0.14 mg/m3), sen, 2007 | |
Occupational Exposure Limit-BELGIUM | time-weighted average 0.005 ppm (0.037 mg/m3), MAR2002 | |
Occupational Exposure Limit-BELGIUM | short term exposure limit 0.02 ppm (0.14 mg/m3), MAR2002 | |
Occupational Exposure Limit-DENMARK | time-weighted average 0.005 ppm (0.035 mg/m3), carc, MAY2011 | |
Occupational Exposure Limit-HUNGARY | ceiling concentration 0.035 mg/m3, Carcinogen, SEP2000 | |
Occupational Exposure Limit-ICELAND | time-weighted average 0.005 ppm (0.04 mg/m3), short term exposure limit 0.01 ppm (0.07 mg/m3), sen, NOV2011 | |
Occupational Exposure Limit-JAPAN | Occupational Exposure Limit 0.005 ppm, skin, 2B carc, s1 sen, MAY2012 | |
Occupational Exposure Limit-JAPAN | ceiling concentration 0.02 ppm (0.14 mg/m3), MAY2012 | |
Occupational Exposure Limit-KOREA | time-weighted average 0.005 ppm (0.04 mg/m3), short term exposure limit 0.02 ppm (0.15 mg/m3), 2006 | |
Occupational Exposure Limit-MEXICO | time-weighted average 0.02 ppm (0.14 mg/m3), 2004 | |
Occupational Exposure Limit-NEW ZEALAND | time-weighted average 0.02 mg(NCO)/m3; short term exposure limit 0.07 mg(NCO)/m3, sen, JAN2002 | |
Occupational Exposure Limit-NORWAY | time-weighted average 0.005 ppm (0.035 mg/m3), JAN1999 | |
Occupational Exposure Limit-PERU | time-weighted average 0,005 ppm (0,036 mg/m3); short term exposure limit 0,02 ppm (0,014 mg/m3), JUL2005 | |
Occupational Exposure Limit-POLAND | MAC(time-weighted average) 0.035 mg/m3, MAC(short term exposure limit) 0.070 mg/m3, JAN1999 | |
Occupational Exposure Limit-RUSSIA | short term exposure limit 0.05 mg/m3, JUN2003 | |
Occupational Exposure Limit-SWEDEN | time-weighted average 0.002 ppm (0.014 mg/m3), Carcinogen, Sen, JUN2005 | |
Occupational Exposure Limit-SWEDEN | ceiling concentration 0.005 ppm (0.04 mg/m3), JUN2005 | |
Occupational Exposure Limit-SWITZERLAND | ceiling concentration 0.02 mg(NCO)/m3, skin, sen, JAN2011 | |
Occupational Exposure Limit-THAILAND | time-weighted average 0.02 ppm (0.14 mg/m3), JAN1993 | |
Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 0.04 mg/m3, 2003 | |
Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 0.02 ppm (0.14 mg/m3), JAN1993 | |
Occupational Exposure Limit-TURKEY | time-weighted average 0.02 ppm (0.14 mg/m3), JAN1993 | |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | ceiling concentration 0.02 ppm (0.14 mg/m3) | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | ceiling concentration 0.02 ppm (0.14 mg/m3) | CFRGBR 41,50-204.50,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | ceiling concentration 0.02 ppm (0.14 mg/m3) | CFRGBR 29,1910.1000,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | ceiling concentration 0.02 ppm (0.14 mg/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TOLUENE DIISOCYANATE-air | Carcinogen lowest feasible conc | NIOSH* DHHS#92-100,1992 |
National Occupational Exposure Survey 1983 | Hazard Code 73390; Number of Industries 19; Total Number of Facilities 838; Number of Occupations 30; Total Number of Employees Exposed 10921; Total Number of Female Employees Exposed 545 | |
National Occupational Hazard Survey 1974 | Hazard Code 73390; Number of Industries 47; Total Number of Facilities 2310; Number of Occupations 54; Total Number of Employees Exposed 26654 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health