Aziridine, 2-methyl-
RTECS #
CM8050000
CAS #
Updated
March 2018
Molecular Weight
57.11
Molecular Formula
C3H7N
Synonyms
1,2-Propyleneimine
1,2-Propylenimine
2-Methylazacyclopropane
2-Methylaziridine
2-Methylethylenimine
Methylethylenimine
Propylene imine
Propylene imine (ACGIH:OSHA)
Propylenimine
RCRA waste number P067
1,2-Propylenimine
2-Methylazacyclopropane
2-Methylaziridine
2-Methylethylenimine
Methylethylenimine
Propylene imine
Propylene imine (ACGIH:OSHA)
Propylenimine
RCRA waste number P067
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
DNA Damage | intraperitoneal/mouse | 40 mg/kg | MUREAV 467,83,2000 |
DNA Damage | lung/hamster | 300 µmol/L/1H | BBRCA9 72,732,1976 |
DNA repair | /Escherichia coli | 2 µg/plate | JJIND8 62,873,1979 |
gene conversion and mitotic recombination | /Saccharomyes cerevisiae | 100 ppm | JJIND8 62,901,1979 |
host-mediated assay | Salmonella typhimurium/mouse | 355 mg/kg | JJIND8 62,911,1979 |
micronucleus test | intraperitoneal/mouse | 10 mg/kg | MUREAV 389,3,1997 |
morphological transform | fibroblast/mouse | 80 µg/L | JJIND8 67,1303,1981 |
morphological transform | embryo/hamster | 1 mg/L | JJIND8 67,1303,1981 |
morphological transform | embryo/rat | 15 mg/L | JJIND8 67,1303,1981 |
mutation in microorganisms | /Schizosaccharomyces pombe | 5470 µmol/L (-enzymatic activation step) | ADWMAX -,193,1962 |
mutation in microorganisms | /Salmonella typhimurium | 3300 ng/plate (+/-enzymatic activation step) | ENMUDM 6(Suppl 2),1,1984 |
mutation in microorganisms | /Escherichia coli | 10 µg/plate (+enzymatic activation step) | ENMUDM 6(Suppl 2),1,1984 |
other mutation test systems | /Escherichia coli | 80 nmol/tube | MUREAV 147,79,1985 |
specific locus test | oral/Drosophila melanogaster | 1 mmol/L | MUREAV 252,305,1991 |
Unscheduled DNA Synthesis | liver/rat | 10 mg/L | MUREAV 97,359,1982 |
Tumorigenic Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
oral/rat | lowest published toxic dose: 1120 mg/kg/28W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Brain and Coverings: Tumors Skin and Appendages: Tumors | NATUAS 230,460,1971 |
oral/rat | toxic dose: 3920 mg/kg/27W- continuous | Tumorigenic: Carcinogenic by RTECS criteria Blood: Leukemia Skin and Appendages: Tumors | JJIND8 67,75,1981 |
oral/rat | toxic dose: 4129 mg/kg/58W- continuous | Tumorigenic: Carcinogenic by RTECS criteria Skin and Appendages: Tumors | JJIND8 67,75,1981 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/guinea pig | Lowest published lethal concentration: 500 ppm/1H | Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Lung, Thorax, or Respiration: Dyspnea Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) | JIHTAB 30,2,1948 |
inhalation/mouse | Lethal concentration: >2 gm/m3/10M | NDRC** NDCrc-132,Feb,1942 | |
inhalation/rat | Lowest published lethal concentration: 500 ppm/4H | JIHTAB 31,343,1949 | |
intraperitoneal/mouse | lethal dose (50 percent kill): 355 mg/kg | JJIND8 62,911,1979 | |
oral/rat | lethal dose (50 percent kill): 19 mg/kg | JIHTAB 30,63,1948 | |
skin/guinea pig | lethal dose (50 percent kill): 43 mL/kg | JIHTAB 30,63,1948 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.2 ppm;short term exposure limit 0.4 ppm (skin) | DTLVS* TLV/BEI,2013 |
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Confirmed animal carcinogen | DTLVS* TLV/BEI,2013 |
International Agency for Research on Cancer (IARC) | Cancer Review:Animal Sufficient Evidence | IMEMDT 9,61,1975 |
International Agency for Research on Cancer (IARC) | Cancer Review:Animal Sufficient Evidence | IMEMDT 71,1497,1999 |
International Agency for Research on Cancer (IARC) | Cancer Review:Human No Adequate Data | IMEMDT 9,61,1975 |
International Agency for Research on Cancer (IARC) | Cancer Review:Human No Adequate Data | IMEMDT 71,1497,1999 |
International Agency for Research on Cancer (IARC) | Cancer Review:Group 2B | IMEMDT 71,1497,1999 |
TOXICOLOGY REVIEW | MUREAV 721,27,2011 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 2 ppm (5 mg/m3) (skin) | DTLVS* 3,218,1971 |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
Occupational Exposure Limit-AUSTRALIA | time-weighted average 2 ppm (4.7 mg/m3), Carcinogen, JUL2008 | |
Occupational Exposure Limit-BELGIUM | time-weighted average 2 ppm (4.8 mg/m3), Skin, Carcinogen, MAR2002 | |
Occupational Exposure Limit-DENMARK | time-weighted average 2 ppm (5 mg/m3), skin, carc, MAY2011 | |
Occupational Exposure Limit-FINLAND | short term exposure limit 2 ppm (4.7 mg/m3), skin, NOV2011 | |
Occupational Exposure Limit-HUNGARY | ceiling concentration 5 mg/m3, Carcinogen, SEP2000 | |
Occupational Exposure Limit-ICELAND | time-weighted average 2 ppm (5 mg/m3), carc, skin, NOV2011 | |
Occupational Exposure Limit-JAPAN | Occupational Exposure Limit 2 ppm (4.7 mg/m3), skin, MAY2012 | |
Occupational Exposure Limit-KOREA | time-weighted average 2 ppm (5 mg/m3), skin, 2006 | |
Occupational Exposure Limit-MEXICO | time-weighted average 2 ppm (5 mg/m3), 2004 | |
Occupational Exposure Limit-NEW ZEALAND | time-weighted average 2 ppm (4.7 mg/m3), skin, JAN2002 | |
Occupational Exposure Limit-PERU | time-weighted average 2 ppm (4.7 mg/m3), JUL2005 | |
Occupational Exposure Limit-RUSSIA | time-weighted average 2 ppm, JUN2003 | |
Occupational Exposure Limit-SWEDEN | Group B Carcinogen, JUN2005 | |
Occupational Exposure Limit-SWITZERLAND | MAK-week 2 ppm (5 mg/m3), carc 2, skin, JAN2011 | |
Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 0.6 µg/m3, 2003 | |
Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 2 ppm (5 mg/m3), Skin, JAN1993 | |
Occupational Exposure Limit-TURKEY | time-weighted average 2 ppm (5 mg/m3), Skin, JAN1993 | |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 2 ppm (5 mg/m3) (skin) | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 2 ppm (5 mg/m3) (skin) | CFRGBR 41,50-204.50,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 2 ppm (5 mg/m3) (skin) | CFRGBR 29,1910.1000,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 2 ppm (5 mg/m3) (skin) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PROPYLENE IMINE-air | 10H Carcinogen time-weighted average 2 ppm (Sk) | NIOSH* DHHS #92-100,1992 |
National Occupational Hazard Survey 1974 | Hazard Code 08390; Number of Industries 1; Total Number of Facilities 5; Number of Occupations 2; Total Number of Employees Exposed 20 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health