Aniline, N-methyl-N,2,4,6-tetranitro-
RTECS #
BY6300000
CAS #
Updated
September 2013
Molecular Weight
287.17
Molecular Formula
C7H5N5O8
Synonyms
2,4,6-Tetryl
2,4,6-Trinitrophenylmethylnitramine
2,4,6-Trinitrophenylmethylnitramine (OSHA)
2,4,6-Trinitrophenyl-N-methylnitramine
Benzenamine, N-methyl-N,2,4,6-tetranitro- (9CI)
CE
Nitramine
Nitramine (indicator)
N-Methyl-N,2,4,6-tetranitroaniline
N-Methyl-N,2,4,6-tetranitrobenzenamine
N-Methyl-N-2,4,6-tetranitroaniline
Picrylmethylnitramine
Picrylnitromethylamine
Tetralit
Tetralite
Tetril
Tetryl
Tetryl (ACGIH:OSHA)
2,4,6-Trinitrophenylmethylnitramine
2,4,6-Trinitrophenylmethylnitramine (OSHA)
2,4,6-Trinitrophenyl-N-methylnitramine
Benzenamine, N-methyl-N,2,4,6-tetranitro- (9CI)
CE
Nitramine
Nitramine (indicator)
N-Methyl-N,2,4,6-tetranitroaniline
N-Methyl-N,2,4,6-tetranitrobenzenamine
N-Methyl-N-2,4,6-tetranitroaniline
Picrylmethylnitramine
Picrylnitromethylamine
Tetralit
Tetralite
Tetril
Tetryl
Tetryl (ACGIH:OSHA)
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| eye /rabbit | 100 mg | severe | ATDAEI 1,167,1992 |
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| gene conversion and mitotic recombination | /Saccharomyes cerevisiae | 5 µg/plate | TOLED5 5,11,1980 |
| mutation in microorganisms | /Salmonella typhimurium | 25 µg/plate/90M (+enzymatic activation step) | MUREAV 490,45,2001 |
| mutation in microorganisms | /Salmonella typhimurium | 2500 ng/plate (+/-enzymatic activation step) | TOLED5 5,11,1980 |
| mutation in microorganisms | /Neurospora crassa | 5 µg/plate (-enzymatic activation step) | TOLED5 5,11,1980 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/mouse | lowest published lethal dose: 5 gm/kg | Behavioral: Somnolence (general depressed activity) Skin and Appendages: Other: Hair Nutritional and Gross Metabolic: Weight loss or decreased weight gain | ATDAEI 1,167,1992 |
| oral/rat | lowest published lethal dose: 5 gm/kg | Behavioral: Somnolence (general depressed activity) Skin and Appendages: Other: Hair Nutritional and Gross Metabolic: Weight loss or decreased weight gain | ATDAEI 1,167,1992 |
| skin/rabbit | Lethal dose: >2 gm/kg | ATDAEI 1,167,1992 | |
| subcutaneous/Dog | lowest published lethal dose: 5 gm/kg | Liver: Fatty liver degeneration Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli Kidney, Ureter, and Bladder: Interstitial nephritis | JIDHAN 2,247,1920 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/rat | lowest published toxic dose: 5580 mg/kg/90D- continuous | Blood: Other changes Blood: Changes in erythrocyte (RBC) count Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TOXID9 15,202,1995 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 1.5 mg/m3 | DTLVS* TLV/BEI,2013 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 1.5 mg/m3 (skin) | DTLVS* 3,255,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 1.5 mg/m3, JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 1.5 mg/m3, inhal, skin, sen, 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 1.5 mg/m3, MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 1.5 mg/m3, skin, MAY2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 1.5 mg/m3, short term exposure limit 3 mg/m3, skin, NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 1.5 mg/m3, Skin, FEB2006 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 1.5 mg/m3, skin, NOV2011 | |
| Occupational Exposure Limit-KOREA | time-weighted average 1.5 mg/m3, 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 1.5 mg/m3;short term exposure limit 3 mg/m3, 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 1.5 mg/m3, sen, JAN2002 | |
| Occupational Exposure Limit-PERU | time-weighted average 1,5 mg/m3, JUL2005 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 1.5 mg/m3, inhal, skin, sen, JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 1.5 mg/m3, Skin, 2003 | |
| Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 1.5 mg/m3, Skin, JAN1993 | |
| Occupational Exposure Limit-TURKEY | time-weighted average 1.5 mg/m3, JAN1993 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 1.5 mg/m3 (skin) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 1.5 mg/m3 (skin) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 1.5 mg/m3 (skin) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 1.5 mg/m3 (skin) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TETRYL-air | 10H time-weighted average 1.5 mg/m3 (Sk) | NIOSH* DHHS #92-100,1992 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/264271/AS) | |
| EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health