Acetyl chloride, chloro-
RTECS #
AO6475000
CAS #
Updated
December 2018
Molecular Weight
112.94
Molecular Formula
C2H2Cl2O
Synonyms
Chloracetyl chloride
Chlorid kyseliny chloroctove (Czech)
Chloroacetic acid chloride
Chloroacetic chloride
Chloroacetyl chloride
Chloroacetyl chloride (ACGIH)
Chlorure de chloracetyle (French)
Monochloroacetyl chloride
Chlorid kyseliny chloroctove (Czech)
Chloroacetic acid chloride
Chloroacetic chloride
Chloroacetyl chloride
Chloroacetyl chloride (ACGIH)
Chlorure de chloracetyle (French)
Monochloroacetyl chloride
Skin and Eye Irritation and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
eye /rabbit | 0.1 mL | severe | HPV172 -,-,2001 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/mouse | lethal concentration (50 percent kill): 1300 ppm/2H | 85INA8 5,123(89),1986 | |
inhalation/rat | lethal concentration (50 percent kill): 660 ppm/1H | HPV172 -,-,2001 | |
intravenous/mouse | lethal dose (50 percent kill): 32 mg/kg | CSLNX* NX#04538 | |
oral/mouse | lethal dose (50 percent kill): 220 mg/kg | GISAAA 54(2),90,1989 | |
oral/rat | lethal dose (50 percent kill): 208 mg/kg | 85INA8 5,123(89),1986 | |
oral/rat | lowest published lethal dose: 1260 mg/kg | HPV172 -,-,2001 | |
oral/rat | lethal dose (50 percent kill): 207 mg/kg | Lung, Thorax, or Respiration: Acute pulmonary edema Liver: Other changes Blood: Hemorrhage | HPV172 -,-,2001 |
skin/rabbit | lowest published lethal dose: 316 mg/kg | Lung, Thorax, or Respiration: Other changes Blood: Hemorrhage Skin: After topical application: Primary irritation | HPV172 -,-,2001 |
skin/rabbit | lowest published lethal dose: 316 mg/kg | 85INA8 5,123(89),1986 | |
skin/rat | lethal dose (50 percent kill): 662 mg/kg | Skin: After topical application: Corrosive | GISAAA 54(2),90,1989 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/hamster | lowest published toxic concentration: 5 ppm/6H/4W- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTIS** OTS0536493 |
inhalation/mouse | lowest published toxic concentration: 5 ppm/6H/4W- intermittent | Olfaction: Other olfaction effects Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTIS** OTS0536493 |
inhalation/rat | lowest published toxic concentration: 1 ppm/6H/4W- intermittent | Olfaction: Other olfaction effects Behavioral: Somnolence (general depressed activity) Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTIS** OTS0536493 |
inhalation/rat | lowest published toxic concentration: 0.5 ppm/4W- intermittent | Olfaction: Other olfaction effects Lung, Thorax, or Respiration: Other changes | HPV172 -,-,2001 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.05 ppm;short term exposure limit 0.15 ppm (skin) | DTLVS* TLV/BEI,2013 |
TOXICOLOGY REVIEW | RTOPDW 54,247,2009 |
Standards and Regulations
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CHLOROACETYL CHLORIDE-air | 10H time-weighted average 0.05 ppm | NIOSH* DHHS #95-121,1995 |
National Occupational Exposure Survey 1983 | Hazard Code A1131; Number of Industries 1; Total Number of Facilities 21; Number of Occupations 5; Total Number of Employees Exposed 4354; Total Number of Female Employees Exposed 729 | |
National Occupational Hazard Survey 1974 | Hazard Code A1131; Number of Industries 1; Total Number of Facilities 33; Number of Occupations 1; Total Number of Employees Exposed 66 |
Status in Federal Agencies
Organization | Reference |
---|---|
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health