Acetic acid, (2,4,5-trichlorophenoxy)-

RTECS #

AJ8400000

CAS #

93-76-5
See: NMAM or OSHA Methods

Updated

September 2013

Molecular Weight

255.48

Molecular Formula

C₈H₅Cl₃O₃

Synonyms

(2,4,5-Trichloor-fenoxy)-azijnzuur (Dutch)
(2,4,5-Trichlor-phenoxy)-essigsaeure (German)
2,4,5-T
2,4,5-T (ACGIH:OSHA)
2,4,5-Trichlorophenoxyacetic acid (OSHA)
Acide 2,4,5-trichloro phenoxyacetique (French)
Acido (2,4,5-tricloro-fenossi)-acetico (Italian)
Arbokan
BCF-Bushkiller
Brush RHAP
Brush-off 445 low volatile brush killer
Brushtox
Dacamine
Debroussaillant concentre
Debroussaillant super concentre
Ded-weed brush killer
Ded-weed LV-6 brush kil and T-5 brush kil
Envert-T
Estercide T-2 and T-245
Farmco fence rider
Fence rider
Fortex
Fruitone A
Inverton 245
Kwas 2,4,5-trojchlorofenoksyoctowy (Polish)
Line rider
Phortox
RCRA waste number U232
Tippon
Verton 2T
Visko rhap low volatile ester

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Cytogenetic Analysis	oral/Drosophila melanogaster	250 ppm	MUREAV 65,83,1979
Cytogenetic Analysis	ovary/hamster	1750 mg/L	EMMUEG 10(Suppl 10),1,1987
Cytogenetic Analysis	intraperitoneal/mammal (species unspecified)	250 mg/kg/5D- intermittent	JOHEA8 64,213,1973
Cytogenetic Analysis	intraperitoneal/gerbil	250 mg/kg	MUREAV 65,83,1979
Cytogenetic Analysis	parenteral/gerbil	250 mg/kg	ECBUDQ 27,182,1978
Cytogenetic Analysis	intraperitoneal/mouse	4 mg/kg	ARTODN 74,560,2000
DNA Damage	lymphocyte/mammal (species unspecified)	100 µmol/L	PYTCAS 11,3135,1972
DNA Damage	sperm/salmon	100 µmol/L	PYTCAS 11,3135,1972
mutation in microorganisms	/Saccharomyes cerevisiae	35 mg/L (-enzymatic activation step)	ECBUDQ 27,193,1978
mutation in microorganisms	/Bacillus subtilis	1 nmol/plate (-enzymatic activation step)	MSERDS 5,93,1981
sex chromosome loss and nondisjunction	oral/Drosophila melanogaster	1000 ppm/15D	MUREAV 65,83,1979
sex chromosome loss and nondisjunction	unreported route/Drosophila melanogaster	1000 ppm/15D	ECBUDQ 27,182,1978
sister chromatid exchange	ovary/hamster	300 mg/L	EMMUEG 10(Suppl 10),1,1987
specific locus test	multiple/Drosophila melanogaster	10 ppb	EMMUEG 25,148,1995
specific locus test	/Drosophila melanogaster	10 mmol/L	EMMUEG 36,40,2000

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
intraperitoneal/hamster	200 mg/kg (7-11D pregnant)	Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	BECTA6 6,559,1971
oral/hamster	500 mg/kg (7-11D pregnant)	Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Eye, ear Reproductive: Specific developmental abnormalities: Musculoskeletal system	BECTA6 6,559,1971
oral/rat	100 mg/kg (8D pregnant)	Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	PHBHA4 9,357,1972
oral/rat	6 mg/kg (8D pregnant)	Reproductive: Effects on newborn: Behavioral	EXPEAM 39,891,1983
oral/rat	714 mg/kg (multigenerations)	Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	FCTXAV 19,41,1981
oral/rat	27600 µg/kg (10-15D pregnant)	Reproductive: Specific developmental abnormalities: Urogenital system Reproductive: Other developmental abnormalities	EVSRBT 2,708,1973
oral/rat	100 mg/kg (11D pregnant)	Reproductive: Effects on embryo or fetus: Fetal death	BEXBAN 76,831,1973
oral/rat	500 mg/kg (6-10D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)	TJADAB 4,243,1971
oral/mouse	200 mg/kg (6-15D pregnant)	Reproductive: Effects on newborn: Stillbirth	TJADAB 23,33,1981
oral/mouse	6250 µg/kg (10D male)	Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands Reproductive: Other effects on male	TXAPA9 25,441,1973
oral/mouse	300 mg/kg (12D pregnant)	Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)	NSAPCC 272,243,1972
oral/mouse	900 mg/kg (6-15D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)	NSAPCC 272,243,1972
oral/mouse	150 mg/kg (6-15D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	NSAPCC 272,243,1972
oral/mouse	1 gm/kg (8-12D pregnant)	Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	TCMUD8 6,361,1986
subcutaneous/mouse	1 gm/kg (6-15D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Other effects on female Nutritional and Gross Metabolic: Weight loss or decreased weight gain	TXAPA9 20,396,1971
subcutaneous/mouse	1 gm/kg (6-15D pregnant)	Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) Reproductive: Specific developmental abnormalities: Urogenital system	TXAPA9 20,396,1971
subcutaneous/mouse	1 gm/kg (6-15D pregnant)	Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)	TXAPA9 22,317,1972
subcutaneous/mouse	450 mg/kg (6-14D pregnant)	Reproductive: Effects on embryo or fetus: Fetal death Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)	APTOA6 32,408,1973
subcutaneous/rat	300 mg/kg (13-14D pregnant)	Reproductive: Effects on embryo or fetus: Fetal death	TXAPA9 20,396,1971
unreported route/rat	27600 µg/kg (10-15D pregnant)	Reproductive: Effects on embryo or fetus: Fetal death Reproductive: Specific developmental abnormalities: Gastrointestinal system Reproductive: Specific developmental abnormalities: Urogenital system	NTIS** PB223-160
unreported route/rat	278 mg/kg (10-15D pregnant)	Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)	NTIS** PB223-160
unreported route/rat	60 mg/kg (10-15D pregnant)	Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)	NTIS** PB223-160

Tumorigenic Data and References

Route/Organism	Dose	Effect	Reference
oral/mouse	lowest published toxic dose: 3379 mg/kg/33W- continuous	Tumorigenic: Neoplastic by RTECS criteria Kidney, Ureter, and Bladder: Bladder tumors Skin and Appendages: Tumors	BJCAAI 33,626,1976
subcutaneous/mouse	lowest published toxic dose: 215 mg/kg	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors Blood: Tumors	NTIS** PB223-159

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Mouse, embryo	Inhibitor Concentration Low: 0.88 mmol/L/48H	Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Eye, ear	TIVIEQ 4,771,1990
In Vitro/Rat, embryo	Inhibitor Concentration Low: 1.76 mmol/L/48H	Reproductive: Effects on embryo or fetus: Fetal death	TIVIEQ 4,771,1990
In Vitro/Rat, embryo	Inhibitor Concentration Low: 3.52 mmol/L/48H	Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Eye, ear	TIVIEQ 4,771,1990
oral/chicken	lethal dose (50 percent kill): 310 mg/kg	Gastrointestinal: Gastritis Behavioral: Somnolence (general depressed activity) Liver: Fatty liver degeneration	AJVRAH 15,622,1954
oral/Dog	lethal dose (50 percent kill): 100 mg/kg		PAREAQ 14,225,1962
oral/guinea pig	lethal dose (50 percent kill): 381 mg/kg		PCOC** -,1178,1966
oral/hamster	lethal dose (50 percent kill): 425 mg/kg		MUREAV 65,83,1979
oral/mammal (species unspecified)	lethal dose (50 percent kill): 500 mg/kg		SCIEAS 165,465,1969
oral/mouse	lethal dose (50 percent kill): 242 mg/kg		RPZHAW 31,373,1980
oral/rat	lethal dose (50 percent kill): 300 mg/kg		RREVAH 10,97,1965
skin/rat	lethal dose (50 percent kill): 1535 mg/kg		FAATDF 7,299,1986
unreported route/rat	lethal dose (50 percent kill): 500 mg/kg		30ZDA9 -,171,1971

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
oral/Dog	lowest published toxic dose: 700 mg/kg/90D- intermittent	Blood: Changes in other cell count (unspecified) Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	AMIHBC 7,61,1953
oral/mammal (species unspecified)	lowest published toxic dose: 78480 mg/kg/30D- continuous	Behavioral: Somnolence (general depressed activity) Skin and Appendages: Other: Hair Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	NTIS** PB288-416
oral/mouse	lowest published toxic dose: 450 mg/kg/3D- intermittent	Liver: Other changes Liver: Changes in liver weight	TXCYAC 249,176,2008
oral/rat	lowest published toxic dose: 196 mg/kg/28W- intermittent	Liver: Fatty liver degeneration	GTPZAB 30(7),48,1986

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 10 mg/m³	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)	Cancer Review:Human Limited Evidence	IMEMDT 41,357,1986
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Inadequate Evidence	IMEMDT 15,273,1977
TOXICOLOGY REVIEW		RREVAH 59,1,1975
TOXICOLOGY REVIEW		ARPAAQ 94,125,1972
TOXICOLOGY REVIEW		DTTIAF 80,485,1973
TOXICOLOGY REVIEW		RREVAH 56,107,1975
TOXICOLOGY REVIEW		ECMAAI 14,141,1973
TOXICOLOGY REVIEW		BIOGAL 40(2),44,1974
TOXICOLOGY REVIEW		STEVA8 2,305,1974
TOXICOLOGY REVIEW		EVSRBT 2,708,1973
TOXICOLOGY REVIEW		VHTODE 22,31,1980
TOXICOLOGY REVIEW		JTCTDW 38,111,2000
TOXICOLOGY REVIEW		CRTXB2 33,137,2003
TOXICOLOGY REVIEW		ENTOX* -,569,2005
TOXICOLOGY REVIEW		JTEHD6 7,1,2004
TOXICOLOGY REVIEW		HUTOX* -,551,1996
TOXICOLOGY REVIEW		MUREAV 543,251,2003
TOXICOLOGY REVIEW		MUREAV 721,27,2011

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 10 mg/m³	DTLVS* 3,242,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 10 mg/m³, JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 10 mg/m³;KZW 50 mg/m³, inhal, skin, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 10 mg/m³, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 5 mg/m³, skin, MAY2011
Occupational Exposure Limit-FRANCE	VME 10 mg/m³, FEB2006
Occupational Exposure Limit-GERMANY	MAK 2 mg/m³, inhal, skin, 2011
Occupational Exposure Limit-HUNGARY	time-weighted average 10 mg/m³, short term exposure limit 40 mg/m³, Skin, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 5 mg/m³, skin, NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 10 mg/m³, 2006
Occupational Exposure Limit-MEXICO	time-weighted average 10 mg/m³, 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 10 mg/m³, JAN2002
Occupational Exposure Limit-PERU	time-weighted average 10 mg/m³, JUL2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 10 mg/m³, KZG-week 20 mg/m³, inhal, skin, JAN2011
Occupational Exposure Limit-THAILAND	time-weighted average 10 mg/m³, JAN1993
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 10 mg/m³, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 10 mg/m³, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 10 mg/m³	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 10 mg/m³	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 10 mg/m³	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 10 mg/m³	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 2,4,5-T-air	10H time-weighted average 10 mg/m³	NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974	Hazard Code 73900; Number of Industries 2; Total Number of Facilities 177; Number of Occupations 3; Total Number of Employees Exposed 1560

Status in Federal Agencies

Organization	Reference
EPA GENETOX PROGRAM 1988, Inconclusive: Host-mediated assay; Mammalian micronucleus
EPA GENETOX PROGRAM 1988, Negative: D melanogaster-nondisjunction
EPA GENETOX PROGRAM 1988, Negative: D melanogaster-whole sex chrom. loss
EPA GENETOX PROGRAM 1988, Positive/dose response: In vivo cytogenetics-nonhuman bone marrow
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal; S cerevisiae-reversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: 2,4,5-T, 5001
On EPA IRIS database

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health