Acetic acid, isopropyl ester

RTECS #

AI4930000

CAS #

108-21-4
See: NMAM or OSHA Methods

Updated

September 2013

Molecular Weight

102.15

Molecular Formula

C₅H₁₀O₂

Synonyms

2-Acetoxypropane
2-Propyl acetate
Acetate d'isopropyle (French)
Acetic acid, 1-methylethyl ester (9CI)
Isopropile (acetato di) (Italian)
Isopropyl (acetate d') (French)
Isopropyl acetate
Isopropyl acetate (ACGIH:OSHA)
Isopropylacetaat (Dutch)
Isopropylacetat (German)
Isopropylester kyseliny octove (Czech)

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /human	200 ppm/15M		JIHTAB 28,262,1946
skin /rabbit	500 mg/24H	mild	85JCAE -,354,1986

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/human	lowest published toxic concentration: 200 ppm	Lung, Thorax, or Respiration: Other changes	AMIHAB 21,28,1960
inhalation/rat	lethal concentration (50 percent kill): 50600 mg/m³/8H		AIHAAP 20,364,1959
intraperitoneal/rat	Lethal dose: >174 mg/kg		JSGRA2 53,572,1992
intravenous/rat	lowest published lethal dose: 174 mg/kg		JSGRA2 53,572,1992
oral/rabbit	lethal dose (50 percent kill): 6946 mg/kg		IMSUAI 41,31,1972
oral/rat	lethal dose (50 percent kill): 6750 mg/kg		UCDS** 3/24/1970
skin/rabbit	lethal dose (50 percent kill): >20 mL/kg		AMIHBC 10,61,1954
unreported route/human	lowest published toxic concentration: 200 ppm	Eye: Conjunctiva irritation	JIHTAB 28,262,1946

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 100 ppm;short term exposure limit 200 ppm	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		AMIHAB 21,28,1960
TOXICOLOGY REVIEW		HUTOX* -,649,1996

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 250 ppm (950 mg/m³)	DTLVS* 3,141,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 250 ppm (1040 mg/m³), short term exposure limit 310 ppm (1290 mg/m³), JUL2008
Occupational Exposure Limit-BELGIUM	time-weighted average 100 ppm(424 mg/m³), short term exposure limit 200 ppm(849 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 150 ppm (625 mg/m³), MAY2011
Occupational Exposure Limit-FRANCE	VME 250 ppm (950 mg/m³), VLE 300 ppm (1140 mg/m³), FEB2006
Occupational Exposure Limit-GERMANY	MAK 100 ppm (420 mg/m³), 2011
Occupational Exposure Limit-HUNGARY	time-weighted average 840 mg/m³, short term exposure limit 840 mg/m³, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 150 ppm (625 mg/m³), NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 250 ppm (950 mg/m³), short term exposure limit 310 ppm (1185 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 250 ppm (950 mg/m³);short term exposure limit 310 ppm (1185 mg/m³), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 250 ppm (1040 mg/m³); short term exposure limit 310 ppm (1290 mg/m³), JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 100 ppm (240 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 100 ppm (418 mg/m³); short term exposure limit 200 ppm (835 mg/m³), JUL2005
Occupational Exposure Limit-RUSSIA	time-weighted average 50 mg/m³, short term exposure limit 200 mg/m³, JUN2003
Occupational Exposure Limit-SWITZERLAND	MAK-week 100 ppm (420 mg/m³), KZG-week 200 ppm (840 mg/m³), JAN2011
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 250 ppm (950 mg/m³), JAN1993
Occupational Exposure Limit-UNITED KINGDOM	short term exposure limit 200 ppm (849 mg/m³), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 250 ppm (950 mg/m³)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 250 ppm (950 mg/m³)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 250 ppm (950 mg/m³)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 250 ppm (950 mg/m³)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Occupational Exposure Survey 1983	Hazard Code 40984; Number of Industries 85; Total Number of Facilities 8643; Number of Occupations 68; Total Number of Employees Exposed 159819; Total Number of Female Employees Exposed 50913
National Occupational Hazard Survey 1974	Hazard Code 40984; Number of Industries 103; Total Number of Facilities 10160; Number of Occupations 67; Total Number of Employees Exposed 84001

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Isopropyl acetate, 1454

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health