Acetic acid, tert-butyl ester
RTECS #
AF7400000
CAS #
Updated
September 2018
Molecular Weight
116.18
Molecular Formula
C6H12O2
Synonyms
1,1-Dimethyl acetate
Acetic acid, 1,1-dimethylethyl ester (9CI)
t-Butyl acetate
tert-Butyl acetate
tert-Butyl acetate (ACGIH:OSHA)
Texaco lead appreciator
TLA
Acetic acid, 1,1-dimethylethyl ester (9CI)
t-Butyl acetate
tert-Butyl acetate
tert-Butyl acetate (ACGIH:OSHA)
Texaco lead appreciator
TLA
Skin and Eye Irritation and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
eye /rabbit | 100 µL | mild | NTIS** OTS0573684-1 |
skin /rabbit | 500 µL/24H | mild | NTIS** OTS0573684-1 |
Reproductive Effects Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
oral/rat | 22400 mg/kg (6-19D pregnant) | Reproductive: Other effects on female Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system | BDERB* 80,374,2007 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/rat | lethal concentration (50 percent kill): >2230 mg/m3/4H | NTIS** OTS0573684-1 | |
inhalation/rat | Lowest published lethal concentration: 1000 mg/m3 | Lung, Thorax, or Respiration: Other changes Blood: Hemorrhage | RTOPDW 40,168,2004 |
oral/rat | lethal dose (50 percent kill): 4100 mg/kg | Behavioral: Altered sleep time (including change in righting reflex) Behavioral: Ataxia Lung, Thorax, or Respiration: Dyspnea | NTIS** OTS0573684-1 |
oral/rat | lethal dose (50 percent kill): 4500 mg/kg | USXXAM #6673157 | |
skin/rabbit | lethal dose (50 percent kill): >2 gm/kg | Gastrointestinal: Hypermotility, diarrhea Kidney, Ureter, and Bladder: Other changes | NTIS** OTS0573684-1 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/mouse | lowest published toxic dose: 86268 mg/kg/13W- intermittent | Behavioral: Excitement | RTOPDW 68,332,2014 |
inhalation/rat | lowest published toxic dose: 49140 mg/kg/13W- intermittent | Behavioral: Excitement | RTOPDW 68,332,2014 |
oral/rat | lowest published toxic dose: 22400 mg/kg/13D- intermittent | Liver: Changes in liver weight Endocrine: Changes in adrenal weight Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | BDERB* 80,374,2007 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 200 ppm | DTLVS* TLV/BEI,2013 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 200 ppm (950 mg/m3) | DTLVS* 3,31,1971 |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
Occupational Exposure Limit-AUSTRALIA | time-weighted average 200 ppm (950 mg/m3), JUL2008 | |
Occupational Exposure Limit-AUSTRIA | MAK-TMW 20 ppm (96 mg/m3);KZW 20 ppm (96 mg/m3), 2007 | |
Occupational Exposure Limit-BELGIUM | time-weighted average 200 ppm (964 mg/m3), MAR2002 | |
Occupational Exposure Limit-DENMARK | time-weighted average 150 ppm (710 mg/m3), MAY2011 | |
Occupational Exposure Limit-FINLAND | time-weighted average 150 ppm (720 mg/m3), short term exposure limit 200 ppm (960 mg/m3), NOV2011 | |
Occupational Exposure Limit-FRANCE | VME 200 ppm (950 mg/m3), FEB2006 | |
Occupational Exposure Limit-GERMANY | MAK 20 ppm (96 mg/m3), 2011 | |
Occupational Exposure Limit-ICELAND | time-weighted average 150 ppm (700 mg/m3), NOV2011 | |
Occupational Exposure Limit-INDIA | time-weighted average 200 ppm (950 mg/m3), JAN1993 | |
Occupational Exposure Limit-KOREA | time-weighted average 200 ppm (950 mg/m3), 2006 | |
Occupational Exposure Limit-MEXICO | time-weighted average 200 ppm (950 mg/m3);short term exposure limit 250 ppm (1190 mg/m3), 2004 | |
Occupational Exposure Limit-NEW ZEALAND | time-weighted average 200 ppm (950 mg/m3), JAN2002 | |
Occupational Exposure Limit-PERU | time-weighted average 200 ppm (950 mg/m3), JUL2005 | |
Occupational Exposure Limit-POLAND | MAC(time-weighted average) 900 mg/m3, MAC(short term exposure limit) 900 mg/m3, JAN1999 | |
Occupational Exposure Limit-SWEDEN | time-weighted average 100 ppm (500 mg/m3);short term exposure limit 150 ppm (700 mg/m3), JUN2005 | |
Occupational Exposure Limit-SWITZERLAND | MAK-week 20 ppm (96 mg/m3), KZG-week 80 ppm (384 mg/m3), JAN2011 | |
Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 950 mg/m3, 2003 | |
Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 200 ppm (950 mg/m3), JAN1993 | |
Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 200 ppm (966 mg/m3);short term exposure limit 250 ppm (1210 mg/m3), OCT2007 | |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 200 ppm (950 mg/m3) | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 200 ppm (950 mg/m3) | CFRGBR 41,50-204.50,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 200 ppm (950 mg/m3) | CFRGBR 29,1910.1000,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 200 ppm (950 mg/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO t-BUTYL ACETATE-air | 10H time-weighted average 200 ppm | NIOSH* DHHS #92-100,1992 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health