Acetamide, N,N-dimethyl-

RTECS #

AB7700000

CAS #

127-19-5
See: NMAM or OSHA Methods

Updated

March 2019

Molecular Weight

87.14

Molecular Formula

C₄H₉NO

Synonyms

Acetdimethylamide
Acetic acid, dimethylamide
Dimethyl acetamide (ACGIH:OSHA)
Dimethylacetamide
Dimethylacetone amide
Dimethylamid kyseliny octove (Czech)
Dimethylamide acetate
DMA
DMAc
N,N-Dimethylacetamide
NSC 3138
U-5954

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /rabbit	100 mg	mild	DCTODJ 9,147,1986
skin /rabbit	10 mg/24H open irritation test	mild	AIHAAP 23,95,1962

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
DNA inhibition	unreported route/mouse	4400 mg/kg	APHGAO 56,97,1986
sister chromatid exchange	ovary/hamster	10 gm/L	APHGAO 56,97,1986

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	288 ppm/6H (10D male)	Reproductive: Paternal effects: Testes, epididymis, sperm duct	TOXID9 4,65,1984
inhalation/rat	281 ppm/6H (6-15D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	TJADAB 29(2),59A,1984
inhalation/rat	300 ppm/6H (10W pre-3W after birth)	Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	FAATDF 7,132,1986
inhalation/rat	282 ppm/6H (6-15D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	FAATDF 16,414,1991
inhalation/rat	282 ppm (6-15D pregnant)	Reproductive: Other effects on female Reproductive: Other effects to embryo or fetus	CRTXB2 31,139,2001
inhalation/rabbit	570 ppm (7-19D pregnant)	Reproductive: Other effects to embryo or fetus	CRTXB2 31,139,2001
intraperitoneal/rat	2 mg/kg (1D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	85DJA5 -,95,1971
oral/rabbit	3900 mg/kg (6-18D pregnant)	Reproductive: Specific developmental abnormalities: Eye, ear Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) Reproductive: Specific developmental abnormalities: Musculoskeletal system	ARZNAD 30,1557,1980
oral/rabbit	3900 mg/kg (6-18D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	ARZNAD 30,1557,1980
oral/rat	5600 mg/kg (6-19D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)	FAATDF 9,550,1987
oral/rat	5600 mg/kg (6-19D pregnant)	Reproductive: Specific developmental abnormalities: Musculoskeletal system Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system Reproductive: Specific developmental abnormalities: Homeostasis	FAATDF 9,550,1987
oral/rat	5600 mg/kg (6-19D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on embryo or fetus: Fetal death	CRTXB2 31,139,2001
oral/rat	2240 mg/kg (6-19D pregnant)	Reproductive: Other effects on female Reproductive: Other effects to embryo or fetus	CRTXB2 31,139,2001
oral/rat	5600 mg/kg (6-19D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system	CRTXB2 31,139,2001
oral/rat	6 gm/kg (7-21D pregnant)	Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Musculoskeletal system Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system	CRTXB2 31,139,2001
skin/rat	2400 mg/kg (10-11D pregnant)	Reproductive: Effects on embryo or fetus: Fetal death Reproductive: Specific developmental abnormalities: Central nervous system	TXAPA9 41,35,1977

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Human, liver tumor	Inhibitor Concentration Low: 25 mmol/l/24H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. In Vitro Toxicity Studies: Apoptosis in vitro	BESCE5 29,153,2016
In Vitro/jzx	Inhibitor Concentration (50 percent kill): 14.5 pph/60M	In Vitro Toxicity Studies: Other assays	TIVIEQ 26,150,2012
inhalation/mammal (species unspecified)	Lowest published lethal concentration: 406 ppm	Liver: Fatty liver degeneration	TXAPA9 3,12,1961
inhalation/mouse	lethal concentration (50 percent kill): 7200 mg/m³	Behavioral: Ataxia Lung, Thorax, or Respiration: Other changes Liver: Other changes	CHYCDW 13,29,1979
inhalation/rat	lethal concentration (50 percent kill): 2475 ppm/1H	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	DCTODJ 9,147,1986
intraperitoneal/mouse	lethal dose (50 percent kill): 2800 mg/kg		YKIGAK 31,327,1980
intraperitoneal/rat	lethal dose (50 percent kill): 2750 mg/kg		JRPFA4 4,219,1962
intravenous/chicken	lowest published lethal dose: 12 gm/kg		ARZNAD 20,1242,1970
intravenous/mouse	lethal dose (50 percent kill): 3020 mg/kg		ARZNAD 26,1581,1976
intravenous/rabbit	lowest published lethal dose: 8340 mg/kg		ARZNAD 20,1242,1970
intravenous/rat	lethal dose (50 percent kill): 2640 mg/kg		ARZNAD 26,1581,1976
oral/mouse	lethal dose (50 percent kill): 4620 mg/kg		ARZNAD 26,1581,1976
oral/rat	lethal dose (50 percent kill): 4300 mg/kg		GISAAA 45(6),76,1980
skin/mouse	lethal dose (50 percent kill): 9600 mg/kg	Behavioral: Food intake (animal) Lung, Thorax, or Respiration: Other changes Liver: Other changes	CHYCDW 13,29,1979
skin/rabbit	lethal dose (50 percent kill): 2240 mg/kg	Skin: After topical application: Primary irritation	AIHAAP 23,95,1962
skin/rat	lethal dose (50 percent kill): >2 gm/kg		EPASR* 8EHQ-1190-0981
unreported route/rat	lethal dose (50 percent kill): 3 gm/kg		ARZNAD 19,1073,1969

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mouse	lowest published toxic concentration: 700 mg/m³/4H/2W- intermittent	Blood: Pigmented or nucleated red blood cells Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	INHTE5 9,141,1997
inhalation/mouse	lowest published toxic concentration: 375 ppm/6H/78W- intermittent	Eye: Retinal changes pigmentary deposition, retinitis, other) Liver: Other changes Liver: Changes in liver weight	FAATDF 28,80,1995
inhalation/rat	lowest published toxic dose: 103 ppm/6H/26W- intermittent	Liver: Other changes	TXAPA9 3,12,1961
inhalation/rat	lowest published toxic concentration: 300 ppm/6H/12D- intermittent	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Metabolism (intermediary): Lipids including transport	DCTODJ 16,175,1993
inhalation/rat	lowest published toxic concentration: 120 ppm/6H/64D- intermittent	Liver: Changes in liver weight	JTEHD6 27,297,1989
inhalation/rat	lowest published toxic concentration: 100 ppm/6H/2Y- intermittent	Liver: Other changes	FAATDF 28,80,1995
oral/rat	lowest published toxic dose: 15 gm/kg/10D- continuous	Gastrointestinal: Other changes Liver: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	NTIS** OTS0572893
oral/rat	lowest published toxic dose: 364 mg/kg/26W- intermittent	Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases	GISAAA 45(6),76,1980
oral/rat	lowest published toxic dose: 4500 mg/kg/90D- continuous	Blood: Changes in erythrocyte (RBC) count Blood: Changes in leukocyte (WBC) count	DCTODJ 9,147,1986
skin/Dog	lowest published toxic dose: 113 gm/kg/6W- intermittent	Liver: Fatty liver degeneration Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	TXAPA9 3,12,1961
skin/rabbit	lowest published toxic dose: 8 gm/kg/4D- intermittent	Liver: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	DCTODJ 9,147,1986

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 10 ppm (skin)	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		FCTOD7 47,1287,2009
TOXICOLOGY REVIEW		REPTED 58,252,2015

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 10 ppm (35 mg/m³) (skin)	DTLVS* 3,88,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 10 ppm (36 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 10 ppm (36 mg/m³);KZW 20 ppm (72 mg/m³), skin, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 10 ppm (36 mg/m³), MAR2002
Occupational Exposure Limit-BELGIUM	short term exposure limit 20 ppm (72 mg/m³), Skin, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 10 ppm (35 mg/m³), skin, MAY2011
Occupational Exposure Limit-EC	time-weighted average 36 mg/m³ (10 ppm);short term exposure limit 72 mg/m³ (20 ppm), skin, JUN2000
Occupational Exposure Limit-FINLAND	time-weighted average 10 ppm (36 mg/m³), short term exposure limit 20 ppm (72 mg/m³), skin, NOV2011
Occupational Exposure Limit-FRANCE	VME 2 ppm (7.2 mg/m³), VLE 10 ppm (36 mg/m³), Skin, FEB2006
Occupational Exposure Limit-GERMANY	MAK 10 ppm (36 mg/m³), 2011
Occupational Exposure Limit-HUNGARY	time-weighted average 36 mg/m³, short term exposure limit 72 mg/m³, Skin, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 10 ppm (36 mg/m³), short term exposure limit 20 ppm (72 mg/m³), skin, NOV2011
Occupational Exposure Limit-JAPAN	Occupational Exposure Limit 10 ppm (36 mg/m³), skin, MAY2012
Occupational Exposure Limit-KOREA	time-weighted average 10 ppm (35 mg/m³), skin, 2006
Occupational Exposure Limit-MEXICO	time-weighted average 10 ppm (35 mg/m³);short term exposure limit 15 ppm (50 mg/m³) (skin), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 10 ppm (36 mg/m³), skin, JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 10 ppm (35 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 10 ppm (36 mg/m³), JUL2005
Occupational Exposure Limit-POLAND	MAC(time-weighted average) 35 mg/m³, JAN1999
Occupational Exposure Limit-RUSSIA	time-weighted average 1 mg/m³, short term exposure limit 3 mg/m³, Skin, JUN2003
Occupational Exposure Limit-SWEDEN	time-weighted average 10 ppm (35 mg/m³);short term exposure limit 20 ppm (70 mg/m³), Skin, JUN2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 10 ppm (35 mg/m³), KZG-week 20 ppm (70 mg/m³), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 36 mg/m³, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 10 ppm (35 mg/m³), Skin, JAN1993
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 10 ppm (36 mg/m³);short term exposure limit 20 ppm (72 mg/m³), skin, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 10 ppm (35 mg/m³) (skin)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 10 ppm (35 mg/m³) (skin)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 10 ppm (35 mg/m³) (skin)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 10 ppm (35 mg/m³) (skin)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIMETHYL ACETAMIDE-air	10H time-weighted average 10 ppm (Sk)	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 26095; Number of Industries 14; Total Number of Facilities 907; Number of Occupations 27; Total Number of Employees Exposed 28943; Total Number of Female Employees Exposed 15028
National Occupational Hazard Survey 1974	Hazard Code 26095; Number of Industries 5; Total Number of Facilities 66; Number of Occupations 13; Total Number of Employees Exposed 7658

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Dimethylacetamide, 2004

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health