At a glance
The Laboratory Response Network for Biological Threats (LRN-B) is comprised of national, reference, and sentinel laboratories, each with their own responsibilities. The LRN-B enables the United States to detect biological threats and emerging infectious disease quickly and accurately.
National laboratories
National laboratories, including those operated by CDC, U.S. Army Medical Research Institute for Infectious Diseases (USAMRIID), and the National Bioforensics Analysis Center (NBFAC), are responsible for specialized characterization of organisms, bioforensics, select agent activity, and handling highly infectious biological agents.
Reference laboratories
Reference laboratories, often called LRN-B member laboratories, are responsible for investigation and/or referral of specimens. There are approximately 120 domestic state and local public health, military, veterinary, agriculture, and food laboratories. These laboratories receive reagents, protocols, and specialized training to perform testing for multiple agents in high risk environmental or clinical samples. Reference laboratories also provide training and guidance to thousands of sentinel laboratories across the U.S.
Sentinel laboratories
Sentinel laboratories play a key role in the early detection of biological agents. Sentinel laboratories provide routine diagnostic services, rule-out, and referral steps in the identification process. These laboratories can evaluate whether samples should be sent to an LRN reference laboratory for further testing.
CDC's Laboratory Response Network for Biological Threats (LRN-B)
LRN-B factsheet webpage | LRN-B factsheet download
The LRN works with the American Society for Microbiology and state public health laboratory directors to ensure that sentinel laboratories, such as private and commercial laboratories, are part of the LRN. There are an estimated 25,000 private and commercial laboratories in the United States. The majority of these laboratories are hospital-based, clinical institutions, and commercial diagnostic laboratories.