Table 1: Treatment for HBV Exposures in Health Care Settings

At a glance

This table showcases postexposure testing, postexposure prophylaxis, and postvaccination serological testing guidance for health care providers and clinicians, depending on their vaccination status.

Hepatitis B exposure guidelines for health professionals.

Table 1

Treatment for HBV Exposures in Health Care Settings
HCP status Post-exposure testing Post-exposure prophylaxis Post-vaccination serologic testing
Source patient HCP testing HBIG Vaccination
Documented responder after complete series No action needed
Documented non-responder after two complete series Positive/unknown — HBIG x2 separated by 1 month — n/a
Negative No action needed
Response unknown after complete series Positive/unknown <10 mIU/mL HBIG x1 Initiate revaccination Yes
Negative <10 mIU/mL — Initiate revaccination Yes
Any result ≥10 mIU/mL — — —
Unvaccinated/incompletely vaccinated or vaccine refusers Positive/unknown — HBIG x1 Complete vaccination Yes
Negative — None Complete vaccination Yes
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Content Source:
Division of Viral Hepatitis