Fast Facts: Rubella and Congenital Rubella Syndrome (CRS)

At a glance

Rubella is a leading cause of vaccine-preventable birth defects. When a woman is infected with the rubella virus during pregnancy, particularly in the first trimester, the newborn can have birth defects, known as congenital rubella syndrome (CRS).

A health worker performs an exam on an infant.

Impacts

Rubella can cause severe birth defects and death

Rubella infection creates mild symptoms in most children and adults but can cause serious health problems when it happens during pregnancy.

Rubella virus infection is a leading cause of vaccine-preventable birth defects, known as congenital rubella syndrome (CRS). Rubella infection during pregnancy can also lead to miscarriage (loss of the fetus within 20 weeks of conception) and stillbirth (death of the fetus after 20 weeks of pregnancy).

When a pregnant woman is infected with rubella in early pregnancy, she has up to a 90% chance of giving birth to a baby with CRS:

  • CRS can cause hearing impairment, cataracts or glaucoma, heart defects, or developmental delays
  • 33% of infants born with CRS die before their first birthday
  • In 2019, an estimated 32,000 children were born with CRS

Prevention

Rubella is a preventable disease

A health worker performs an exam on an infant.
A health worker examines an infant in Bolivia before the child gets vaccines. ©UNICEF/U.S.CDC/UN0769714 /Czajkowskito

The World Health Organization recommends that all countries include rubella vaccines in their national immunization programs.

Rubella vaccines are safe and effective and have been used for over 50 years. One dose can provide lifelong protection. In most countries, a combined measles and rubella vaccine is used.

Over half the world's countries have eliminated rubella. Most countries include rubella vaccines in their national immunization programs, but 19 countries have not introduced rubella vaccine. The majority of children born with CRS live in these countries.

Rubella vaccination is almost always done with measles vaccination.‎‎

Most vaccines to prevent rubella are also given with a measles vaccine in a single shot. Learn about what CDC is doing to protect children from measles globally: Global Measles Vaccination