May 16, 2024

CDC Global Immunization Strategic Framework

The CDC Global Immunization Strategic Framework 2021–2030 (CDC GISF 2021-2030) is a roadmap for global immunization. Its goal is a world where everyone, everywhere is protected from vaccine-preventable disease (VPDs). The GISF is a framework to provide scientific and programmatic leadership to end VPD threats.

Framework document

CDC Global Immunization Strategic Framework 2021-2030

Global Immunization Strategic Framework cover — CDC Global Immunization Strategic Framework 2021-2030

Vision and goals

Vision‎

The vision of the GISF is a world of healthy people who are protected from VPD disease, disability, and death.

Progress toward that vision is structured around five goals, and implemented using four guiding principles, to achieve health impact objectives.

Three goals are core immunization program aspects that CDC seeks to strengthen:

Prevent VPDs by strengthening immunization services
Detect VPDs by supporting and improving disease surveillance systems
Respond to and prepare for VPD outbreaks

Two goals are cross-cutting:

Sustain immunization program strengths over time
Innovate to increase immunization program impact

Goals of CDC's Global Immunization Strategic Framework 2021-2030

Principles and objectives

Guiding principles and health impact objectives‎

Guiding principles provide the basis for how CDC will work to achieve the greatest impact. Health impact objectives target a continuously updated list of diseases for immunization program engagement.

The guiding principles of the GISF 2021-2030 include:

Data-guided policy and programmatic decision-making
Integrated approach promoting linkages between disease-specific and other initiatives
Partnership-based alliances applying the strengths of each organization
Focused investment that uses strategic information to efficiently allocate resources for impact

The health impact objectives of the GISF 2021-2030 are to:

Advance the development of new and improved vaccines for diseases that are high burden or have epidemic potential
Control diseases to reduce morbidity and mortality to locally acceptable levels
Eliminate transmission of diseases in defined geographic areas and eliminate diseases as a public health problem
Eradicate diseases by stopping all transmission worldwide

CDC GISF 2021-2030 health impact objectives
Advance Development	Control	Eliminate	Eradicate
High Disease Burden Enterotoxigenic E. coli gastroenteritis Group B streptococcal disease HIV/AIDS, malaria respiratory syncytial virus (RSV) disease shigellosis Epidemic or pandemic potential chikungunya Crimean-Congo hemorrhagic fever pandemic influenza Lassa fever Marburg hemorrhagic fever Middle East respiratory syndrome (MERS) Nipah virus disease Rift Valley fever Zika virus disease	With control targets Influenza (seasonal) Japanese encephalitis Tuberculosis Yellow fever Without control targets–with vaccines recommended in all country immunization schedules Diphtheria H. influenzae type b disease Pertussis, pneumococcal disease Rotavirus gastroenteritis Non-neonatal tetanus Without control targets–with vaccines considered based on disease burden Coronavirus disease 2019 (COVID-19) Dengue Ebola virus disease Hepatitis A Hepatitis E Mumps Typhoid Varicella	With targets for elimination of transmission Measles Rubella With targets for elimination of epidemics or as a public health problem Bacterial meningitis (Streptococcus pneumoniae, Neisseria meningitis) Cervical cancer (Human papillomavirus) Cholera Hepatitis B Rabies Tetanus (maternal and neonatal)	Polio

Working with partners

A worldwide alliance for healthier people‎

CDC GISF 2021-2030 facilitates the efficient coordination of immunization efforts across the CDC and among its international partners.

The framework achieves this coordination by defining the agency’s role within a global network of public health and development organizations.

CDC strengthens immunization programs and improves their performance at every level, from local to global. The framework leverages CDC's longstanding epidemiological, laboratory, and programmatic expertise related to VPDs for maximum impact.

The overarching strategies of CDC and its key partners align with and support one another to advance global immunization progress. They also support the ownership of national immunization programs by country governments.