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Volume 30, Number 3—March 2024
CME ACTIVITY - Synopsis

Molecular Epidemiology of Underreported Emerging Zoonotic Pathogen Streptococcus suis in Europe

Jaime BrizuelaComments to Author , Thomas J. Roodsant, Qureisha Hasnoe, Boas C.L. van der Putten, Jana Kozakova, Hans-Christian Slotved, Mark van der Linden, Ilse G.A. de Beer-Schuurman, Ewa Sadowy, Juan Antonio Sáez-Nieto, Victoria J. Chalker, Kees C.H. van der Ark, and Constance Schultsz
Author affiliations: Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands (J. Brizuela, T.J. Roodsant, Q. Hasnoe, B.C.L. van der Putten, I.G.A de Beer-Schuurman, K.C.H. van der Ark, C. Schultsz); National Institute for Public Health, Prague, Czech Republic (J. Kozakova); Statens Serum Institut, Copenhagen, Denmark (H.-C. Slotved); University Hospital RWTH Aachen, Aachen, Germany (M. van der Linden); National Medicines Institute, Warsaw, Poland (E. Sadowy); Carlos III Health Institute, Madrid, Spain (J.A. Sáez-Nieto); UK Health Security Agency, London, UK (V.J. Chalker).

Main Article

Figure 4

Presence/absence matrix of 46 genes putatively associated with zoonotic potential in study of zoonotic Streptococcus suis in Europe. The same phylogenetic tree presented in Figure 3 was used. Blue squares indicate presence of the gene while red squares indicate absence. The colored branches indicate CCs and follow the same pattern as in Figure 3 (blue, CC1; red, CC20; purple, CC87; yellow, CC94; green, CC25). We defined gene presence with 80% protein identity and coverage. We used Phandango (19) to visualize the tree. Bios, biosynthesis; CC, clonal complex; CS, complement system evasion.

Figure 4. Presence/absence matrix of 46 genes putatively associated with zoonotic potential in study of zoonotic Streptococcus suis in Europe. The same phylogenetic tree presented in Figure 3 was used. Blue squares indicate presence of the gene while red squares indicate absence. The colored branches indicate CCs and follow the same pattern as in Figure 3 (blue, CC1; red, CC20; purple, CC87; yellow, CC94; green, CC25). We defined gene presence with 80% protein identity and coverage. We used Phandango (19) to visualize the tree. Bios, biosynthesis; CC, clonal complex; CS, complement system evasion.

Main Article

References
  1. Huong  VTL, Ha  N, Huy  NT, Horby  P, Nghia  HDT, Thiem  VD, et al. Epidemiology, clinical manifestations, and outcomes of Streptococcus suis infection in humans. Emerg Infect Dis. 2014;20:110514. DOIPubMedGoogle Scholar
  2. Nghia  HD, Tu  TP, Wolbers  M, Thai  CQ, Hoang  NV, Nga  TV, et al. Risk factors of Streptococcus suis infection in Vietnam. A case-control study. PLoS One. 2011;6:e17604. DOIPubMedGoogle Scholar
  3. Segura  M, Aragon  V, Brockmeier  SL, Gebhart  C, Greeff  A, Kerdsin  A, et al. Update on Streptococcus suis research and prevention in the era of antimicrobial restriction: 4th International Workshop on S. suis. Pathogens. 2020;9:374. DOIPubMedGoogle Scholar
  4. Goyette-Desjardins  G, Auger  JP, Xu  J, Segura  M, Gottschalk  M. Streptococcus suis, an important pig pathogen and emerging zoonotic agent-an update on the worldwide distribution based on serotyping and sequence typing. Emerg Microbes Infect. 2014;3:e45. DOIPubMedGoogle Scholar
  5. Tall  H, Njanpop-Lafourcade  BM, Mounkoro  D, Tidjani  L, Agbenoko  K, Alassani  I, et al. Identification of Streptococcus suis meningitis through population-based surveillance, Togo, 2010–2014. Emerg Infect Dis. 2016;22:12624. DOIPubMedGoogle Scholar
  6. Raberahona  M, Rasoanandrasana  S, Rahajamanana  VL, Ranaivo-Rabetokotany  F, Andriananja  V, Rakotomalala  FA, et al. Novel Streptococcus suis sequence type 834 among humans, Madagascar. Emerg Infect Dis. 2018;24:3912. DOIPubMedGoogle Scholar
  7. Alarcón L  P, Araya R  P, Aguayo  C, Fernández  J, Illesca  V, Zaror  A, et al. [Laboratory confirmation of Streptococcus suis in Chile] [in Spanish]. Rev Chilena Infectol. 2013;30:53940. DOIPubMedGoogle Scholar
  8. Susilawathi  NM, Tarini  NMA, Fatmawati  NND, Mayura  PIB, Suryapraba  AAA, Subrata  M, et al. Streptococcus suis-Associated Meningitis, Bali, Indonesia, 2014-2017. Emerg Infect Dis. 2019;25:223542. DOIPubMedGoogle Scholar
  9. Kerdsin  A, Hatrongjit  R, Wongsurawat  T, Jenjaroenpun  P, Chopjitt  P, Boueroy  P, et al. Genomic characterization of Streptococcus suis serotype 24 clonal complex 221/234 from human patients. Front Microbiol. 2021;12:812436. DOIPubMedGoogle Scholar
  10. Kerdsin  A. Human Streptococcus suis infections in Thailand: epidemiology, clinical features, genotypes, and susceptibility. Trop Med Infect Dis. 2022;7:359. DOIPubMedGoogle Scholar
  11. Liang  P, Wang  M, Gottschalk  M, Vela  AI, Estrada  AA, Wang  J, et al. Genomic and pathogenic investigations of Streptococcus suis serotype 7 population derived from a human patient and pigs. Emerg Microbes Infect. 2021;10:196074. DOIPubMedGoogle Scholar
  12. King  SJ, Leigh  JA, Heath  PJ, Luque  I, Tarradas  C, Dowson  CG, et al. Development of a multilocus sequence typing scheme for the pig pathogen Streptococcus suis: identification of virulent clones and potential capsular serotype exchange. J Clin Microbiol. 2002;40:367180. DOIPubMedGoogle Scholar
  13. Willemse  N, Howell  KJ, Weinert  LA, Heuvelink  A, Pannekoek  Y, Wagenaar  JA, et al. An emerging zoonotic clone in the Netherlands provides clues to virulence and zoonotic potential of Streptococcus suis. Sci Rep. 2016;6:28984. DOIPubMedGoogle Scholar
  14. Page  MJ, McKenzie  JE, Bossuyt  PM, Boutron  I, Hoffmann  TC, Mulrow  CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71. DOIPubMedGoogle Scholar
  15. Athey  TBT, Teatero  S, Lacouture  S, Takamatsu  D, Gottschalk  M, Fittipaldi  N. Determining Streptococcus suis serotype from short-read whole-genome sequencing data. BMC Microbiol. 2016;16:162. DOIPubMedGoogle Scholar
  16. Tonkin-Hill  G, MacAlasdair  N, Ruis  C, Weimann  A, Horesh  G, Lees  JA, et al. Producing polished prokaryotic pangenomes with the Panaroo pipeline. Genome Biol. 2020;21:180. DOIPubMedGoogle Scholar
  17. Page  AJ, Taylor  B, Delaney  AJ, Soares  J, Seemann  T, Keane  JA, et al. SNP-sites: rapid efficient extraction of SNPs from multi-FASTA alignments. Microb Genom. 2016;2:e000056. DOIPubMedGoogle Scholar
  18. Nguyen  LT, Schmidt  HA, von Haeseler  A, Minh  BQ. IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies. Mol Biol Evol. 2015;32:26874. DOIPubMedGoogle Scholar
  19. Hadfield  J, Croucher  NJ, Goater  RJ, Abudahab  K, Aanensen  DM, Harris  SR. Phandango: an interactive viewer for bacterial population genomics. Bioinformatics. 2018;34:2923. DOIPubMedGoogle Scholar
  20. Roodsant  TJ, Van Der Putten  BCL, Tamminga  SM, Schultsz  C, Van Der Ark  KCH. Identification of Streptococcus suis putative zoonotic virulence factors: A systematic review and genomic meta-analysis. Virulence. 2021;12:278797. DOIPubMedGoogle Scholar
  21. Augère-Granier  M-L. European Parliamentary Research Service. The EU pig meat sector [cited 2022 Nov 8]. https://www.europarl.europa.eu/RegData/etudes/BRIE/2020/652044/EPRS_BRI(2020)652044_EN.pdf
  22. Public Health England, Department for Environment, Food and Rural Affairs. Zoonoses: UK annual reports: 2017 [cited 2022 Nov 8]. https://www.gov.uk/government/publications/zoonoses-uk-annual-reports
  23. National Institute for Public Health and the Environment. Zoonotic infections with Streptococcus suis in the Netherlands/IB 11–2013 [in Dutch] [cited 2022 Nov 8]. https://www.rivm.nl/weblog/zoonotische-infecties-met-streptococcus-suis-in-nederland-ib-11-2013
  24. @mrvr79. Meningitis due to Streptococcus suis in a butcher [in Spanish]. 2020 Dec 19 [cited 2022 Apr 1]. https://twitter.com/mrvr79/status/1340282705439801345
  25. Goyette-Desjardins  G, Auger  JP, Dolbec  D, Vinogradov  E, Okura  M, Takamatsu  D, et al. Comparative study of immunogenic properties of purified capsular polysaccharides from Streptococcus suis serotypes 3, 7, 8, and 9: the serotype 3 polysaccharide induces an opsonizing IgG response. Infect Immun. 2020;88:e0037720. DOIPubMedGoogle Scholar
  26. Wang  J, Kong  D, Zhang  S, Jiang  H, Zheng  Y, Zang  Y, et al. Interaction of fibrinogen and muramidase-released protein promotes the development of Streptococcus suis meningitis. Front Microbiol. 2015;6:1001. DOIPubMedGoogle Scholar
  27. Kong  D, Chen  Z, Wang  J, Lv  Q, Jiang  H, Zheng  Y, et al. Interaction of factor H-binding protein of Streptococcus suis with globotriaosylceramide promotes the development of meningitis. Virulence. 2017;8:1290302. DOIPubMedGoogle Scholar
  28. Haas  B, Vaillancourt  K, Bonifait  L, Gottschalk  M, Grenier  D. Hyaluronate lyase activity of Streptococcus suis serotype 2 and modulatory effects of hyaluronic acid on the bacterium’s virulence properties. BMC Res Notes. 2015;8:722. DOIPubMedGoogle Scholar
  29. Brizuela  J, Kajeekul  R, Roodsant  TJ, Riwload  A, Boueroy  P, Pattanapongpaibool  A, et al. Streptococcus suis outbreak caused by an emerging zoonotic strain with acquired multi-drug resistance in Thailand. Microb Genom. 2023;9:mgen000952. DOIPubMedGoogle Scholar
  30. Bojarska  A, Molska  E, Janas  K, Skoczyńska  A, Stefaniuk  E, Hryniewicz  W, et al. Streptococcus suis in invasive human infections in Poland: clonality and determinants of virulence and antimicrobial resistance. Eur J Clin Microbiol Infect Dis. 2016;35:91725. DOIPubMedGoogle Scholar
  31. Estrada  AA, Gottschalk  M, Rossow  S, Rendahl  A, Gebhart  C, Marthaler  DG. Serotype and genotype (multilocus sequence type) of Streptococcus suis isolates from the United States serve as predictors of pathotype. J Clin Microbiol. 2019;57:e0037719. DOIPubMedGoogle Scholar
  32. Dumesnil  A, Auger  JP, Roy  D, Vötsch  D, Willenborg  M, Valentin-Weigand  P, et al. Characterization of the zinc metalloprotease of Streptococcus suis serotype 2. Vet Res (Faisalabad). 2018;49:109. DOIPubMedGoogle Scholar
  33. Roy  D, Fittipaldi  N, Dumesnil  A, Lacouture  S, Gottschalk  M. The protective protein Sao (surface antigen one) is not a critical virulence factor for Streptococcus suis serotype 2. Microb Pathog. 2014;67-68:315. DOIPubMedGoogle Scholar
  34. Spoerry  C, Seele  J, Valentin-Weigand  P, Baums  CG, von Pawel-Rammingen  U. Identification and characterization of IgdE, a novel IgG-degrading protease of Streptococcus suis with unique specificity for porcine IgG. J Biol Chem. 2016;291:791525. DOIPubMedGoogle Scholar
  35. Seele  J, Beineke  A, Hillermann  LM, Jaschok-Kentner  B, von Pawel-Rammingen  U, Valentin-Weigand  P, et al. The immunoglobulin M-degrading enzyme of Streptococcus suis, IdeSsuis, is involved in complement evasion. Vet Res (Faisalabad). 2015;46:45. DOIPubMedGoogle Scholar
  36. Takeuchi  D, Kerdsin  A, Akeda  Y, Chiranairadul  P, Loetthong  P, Tanburawong  N, et al. Impact of a food safety campaign on Streptococcus suis infection in humans in Thailand. Am J Trop Med Hyg. 2017;96:13707. DOIPubMedGoogle Scholar
  37. Yu  H, Jing  H, Chen  Z, Zheng  H, Zhu  X, Wang  H, et al.; Streptococcus suis study groups. Human Streptococcus suis outbreak, Sichuan, China. Emerg Infect Dis. 2006;12:91420. DOIPubMedGoogle Scholar
  38. European Centre for Disease Prevention and Control. Surveillance atlas of infectious diseases [cited 2023 Jul 27]. https://www.ecdc.europa.eu/en/surveillance-atlas-infectious-diseases

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Page created: January 12, 2024
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