Volume 30, Number 2—February 2024
Dispatch
Identification of Large Adenovirus Infection Outbreak at University by Multipathogen Testing, South Carolina, USA, 2022
Table 1
Characteristics |
Adenovirus infections |
---|---|
Total no. infected students |
195 |
Sex | |
M | 97 (50) |
F | 98 (50) |
Median age, y (range) |
19 (18–24) |
Academic class | |
Freshman | 76 (39) |
Sophomore | 58 (30) |
Junior | 33 (17) |
Senior | 25 (13) |
Graduate student |
3 (1) |
Residence | |
On-campus dormitory | 115 (59) |
On-campus apartment | 6 (3) |
Off campus | 68 (35) |
Unknown |
6 (3) |
Area of academic study | |
Prebusiness or business | 41 (21) |
Finance | 17 (9) |
Biology | 17 (9) |
Psychology | 13 (7) |
Public health | 9 (5) |
Sports/entertainment management | 8 (4) |
Undeclared | 8 (4) |
Political science | 7 (4) |
All others |
75 (38) |
Symptoms† | |
Cough | 149 (76) |
Sore throat | 166 (85) |
Fever | 146 (75) |
Headache | 120 (62) |
GI | 52 (27) |
Conjunctivitis |
20 (10) |
Smoking or vaping |
30 (15) |
Comorbidities | |
Asthma | 14 (7) |
Immunocompromised‡ | 2 (1) |
Other or not reported |
179 (92) |
Co-detected respiratory viruses§ | |
Human rhinovirus/enterovirus | 28 (14) |
Seasonal coronavirus¶ | 9 (5) |
SARS-CoV-2 | 8 (4) |
Parainfluenza, types 2–4 | 6 (3) |
Influenza A | 1 (1) |
RSV | 1 (1) |
Human metapneumovirus |
1 (1) |
Adenovirus typing by hexon gene sequencing | |
Human adenovirus type 4 | 30 (15) |
Not typed# | 165 (85) |
*Values are no. (%) except as indicated. †Students could report multiple symptoms. ‡Immunocompromised because of methotrexate or immunomodulatory agent treatment. §Other respiratory viruses were detected by using multipathogen PCR. A total of 43 students tested positive for human adenovirus (HAdV) and >1 other respiratory pathogen. Ten of 43 students tested positive for HAdV and >2 other pathogens; 5 of those students had HAdV, SARS-CoV-2, and human rhinovirus/enterovirus. One student tested positive for HAdV, SARS-COV-2, parainfluenza 2, and human rhinovirus/enterovirus. Additional testing, including typing or genomic sequencing, was not performed on specimens that were negative for HAdV. ¶Seasonal coronavirus types were OC43, 229E, NL63, and HKU1. #Typing not attempted or not possible.