Volume 29, Number 4—April 2023
Research Letter
Retrospective Screening of Clinical Samples for Monkeypox Virus DNA, California, USA, 2022
Caitlin A. Contag
, Jacky Lu, Zachary T. Renfro, Abraar Karan, Jorge L. Salinas, Michelle Khan, Daniel Solis, Malaya K. Sahoo, Fumiko Yamamoto, and Benjamin A. Pinsky
, Jacky Lu, Zachary T. Renfro, Abraar Karan, Jorge L. Salinas, Michelle Khan, Daniel Solis, Malaya K. Sahoo, Fumiko Yamamoto, and Benjamin A. Pinsky
Table
Patients with newly diagnosed mpox via retrospective qPCR of oropharyngeal or rectal swab samples, California, USA, 2022*
| Age, y/sex | Sample type, Ct values† |
Clinical manifestations and history | History of HIV or PrEP | Concurrent STI | |
|---|---|---|---|---|---|
| Oropharyngeal | Rectal | ||||
| 55/M | ND/ND | 28.6/29.4 | Asymptomatic; sought CT/NG testing after notification of STI exposure 2 wks before at a sex club in Europe; specific sexual practice unknown | PrEP | Syphilis |
| 30/M | ND/ND | 35.5/35.1 | Asymptomatic; undergoing routine CT/NG screening; exposure unknown | PrEP | None diagnosed |
| 17/M | 37.5/38.2 | 22.0/24.0 | Asymptomatic; undergoing STI screening after recent vaginal sex and receptive and insertive oral and anal sex with male and female partners; timing of exposure unknown; MPXV-positive cutaneous lesions subsequently developed | HIV-1–negative; not on PrEP | Chlamydia, gonorrhea, syphilis |
| 31/M | 29.6/29.8 | Not collected | Sore throat, tonsillar exudates, and lymphadenopathy 4 d after sexual encounter with a male partner 11 d before testing | Unknown | None diagnosed |
| 29/M | ND/ND | 17.2/17.9 | Hematochezia; reported receptive anal sex 4 wk before testing | HIV-1–positive | None diagnosed |
| 46/M |
34.2/34.7 |
19.1/19.2 |
Hematochezia and rectal pain; reported recent receptive anal sex |
HIV-1–positive |
Chlamydia, gonorrhea |
| *Ct, cycle threshold; CT/NG, Chlamydia trachomatis and Neisseria gonorrhoeae; MPXV, monkeypox virus; ND, not detected; PrEP, preexposure prophylaxis; qPCR, quantitative PCR; STI, sexually transmitted infection. †Results indicate Ct for viral DNA polymerase/viral tumor necrosis factor receptor. |
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Page created: February 13, 2023
Page updated: March 21, 2023
Page reviewed: March 21, 2023
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