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Volume 28, Number 3—March 2022
Dispatch

Relationship of SARS-CoV-2 Antigen and Reverse Transcription PCR Positivity for Viral Cultures

Dustin W. CurrieComments to Author , Melisa M. Shah, Phillip P. Salvatore, Laura Ford, Melissa J. Whaley, Jennifer Meece, Lynn Ivacic, Natalie J. Thornburg, Azaibi Tamin, Jennifer L. Harcourt, Jennifer Folster, Magdalena Medrzycki, Shilpi Jain, Phili Wong, Kimberly Goffard, Douglas Gieryn, Juliana Kahrs, Kimberly Langolf, Tara Zochert, Christopher H. Hsu, Hannah L. Kirking, Jacqueline E. Tate, and for the CDC COVID-19 Response Epidemiology Field Studies Team1
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (D.W. Currie, M.M. Shah, P.P. Salvatore, L. Ford, M.J. Whaley, N.J. Thornburg, A. Tamin, J.L. Harcourt, J. Folster, M. Medrzycki, S. Jain, P. Wong, C.H. Hsu, H.L. Kirking, J.E. Tate); Marshfield Clinic Research Institute, Marshfield, Wisconsin, USA (J. Meece, L. Ivacic); Winnebago County Health Department, Oshkosh, Wisconsin, USA (K. Goffard, D. Gieryn); University of Wisconsin‒Oshkosh, Oshkosh (J. Kahrs, K. Langolf, T. Zochert)

Main Article

Figure

Box plots of Ct values among participants with recoverable virus who had concordant positive SARS-CoV-2 RT-PCR and antigen test results (A) compared with those who had positive RT-PCR and negative antigen test results (B), Winnebago County, Wisconsin, USA, November–December 2020. The difference between the 2 groups was significant (p<0.0001). Diamonds indicate means, boxes indicate the first quartile through the third quartile, horizontal bars in boxes indicate medians, and errors bars indicate minimum values to maximum values; outliers are plotted as individual circles. Ct, cycle threshold; RT-PCR, reverse transcription PCR; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.

Figure. Box plots of Ct values among participants with recoverable virus who had concordant positive SARS-CoV-2 RT-PCR and antigen test results (A) compared with those who had positive RT-PCR and negative antigen test results (B), Winnebago County, Wisconsin, USA, November–December 2020. The difference between the 2 groups was significant (p<0.0001). Diamonds indicate means, boxes indicate the first quartile through the third quartile, horizontal bars in boxes indicate medians, and errors bars indicate minimum values to maximum values; outliers are plotted as individual circles. Ct, cycle threshold; RT-PCR, reverse transcription PCR; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.

Main Article

1Members of CDC COVID-19 Response Epidemiology Field Studies Team who collected data are listed at the end of this article.

Page created: November 12, 2021
Page updated: February 21, 2022
Page reviewed: February 21, 2022
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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