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Volume 26, Number 2—February 2020
Research

Novel Subclone of Carbapenem-Resistant Klebsiella pneumoniae Sequence Type 11 with Enhanced Virulence and Transmissibility, China

Kai Zhou1, Tingting Xiao1, Sophia David1, Qin Wang, Yanzi Zhou, Lihua Guo, David Aanensen, Kathryn E. Holt, Nicholas R. Thomson, Hajo Grundmann2, Ping Shen2, and Yonghong Xiao2Comments to Author 
Author affiliations: First Affiliated Hospital of Southern University of Science and Technology (Shenzhen People’s Hospital); Shenzhen, China (K. Zhou); The Second Clinical Medical College of Jinan University, Shenzhen (K. Zhou); Zhejiang University, Hangzhou, China (T. Xiao, Q. Wang, Y. Zhou, L. Guo, P. Shen, Y. Xiao); Centre for Genomic Pathogen Surveillance, Cambridge, UK (S. David, D. Aanensen); University of Melbourne, Melbourne, Victoria, Australia (K.E. Holt); London School of Hygiene and Tropical Medicine, London, UK (K.E. Holt, N.R. Thomson); Wellcome Trust Sanger Centre, Cambridge (N.R. Thomson); University of Freiburg, Freiburg, Germany (H. Grundmann)

Main Article

Figure 1

Kaplan–Meier survival estimates for patients with bloodstream infections caused by ST11-KL47, ST11-KL64, and non-ST11 CRKP, China, 2013–2017. A significant difference was found in the 30-day mortality among the 3 groups (p = 0.039). ST11-KL64–infected patients showed significantly higher overall 30-day mortality than ST11-KL47–infected patients (62.2% vs. 52.8%; p = 0.039) and non-ST11 CRKP–infected patients (62.2% vs. 44.8%; p = 0.05). No significant difference in 30-day mortality was found bet

Figure 1. Kaplan–Meier survival estimates for patients with bloodstream infections caused by ST11-KL47, ST11-KL64, and non-ST11 CRKP, China, 2013–2017. A significant difference was found in the 30-day mortality among the 3 groups (p = 0.039). ST11-KL64–infected patients showed significantly higher overall 30-day mortality than ST11-KL47–infected patients (62.2% vs. 52.8%; p = 0.039) and non-ST11 CRKP–infected patients (62.2% vs. 44.8%; p = 0.05). No significant difference in 30-day mortality was found between patients infected with ST11-KL47 and non-ST11 CRKP (52.8% vs. 44.8%, p = 0.529). CRKP, carbapenem-resistant Klebsiella pneumoniae; KL, capsular loci; ST, sequence type.

Main Article

1These first authors contributed equally to this article.

2These senior authors contributed equally to this article.

Page created: January 17, 2020
Page updated: January 17, 2020
Page reviewed: January 17, 2020
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