A brief report on juvenile amyotrophic lateral sclerosis cases in the United States National ALS Registry: 2010–2018

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Affiliates Jaime Raymond [1], Jasmine Berry [1], Edward J. Kasarskis [2], Theodore Larson [1], D. Kevin Horton [1] and Paul Mehta [1]

Received 04 Aug 2023, Accepted 20 Sep 2023, Published online: 03 Oct 2023

[1] Agency for Toxic Substances and Disease Registry/Centers for Disease Control and Prevention, Atlanta, GA, USA
[2] Department of Neurology, University of Kentucky College of Medicine, Lexington, KY, USA
Journal Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Summary This paper describes the demographic characteristics of Juvenile ALS (jALS), designated as presenting ALS symptoms before age 25, in the United States between 2010 and 2018. Forty-four cases of were identified in National ALS Registry data, of which the majority were non-white and male. More research is needed to better understand risk factors contributing to jALS, which could lead to earlier diagnosis and therapeutic interventions.
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