L1CAM immunocapture generates a unique extracellular vesicle population with a reproducible miRNA fingerprint

Key points

Examines the use of extracellular vesicle-derived microRNA as biomarkers for detecting ALS. The analysis generated microRNA fingerprints unique to ALS.

Screenshot of the first two pages of Dunlop L1CAM paper

Affiliate

Rachael Anne Dunlop[1], Sandra Anne Banack[1], and Paul Alan Cox[1]

  1. Brain Chemistry Labs, Jackson, Wyoming, USA

Journal

RNA Biology

Summary

This paper examines the use of microRNA (miRNA) extracted from extracellular vesicles (EVs) purified via L1CAM enrichment as biomarkers for detecting ALS. Comparisons between L1CAM immunocapture and control groups show that the generation of a unique miRNA fingerprint diagnostic of ALS. Further analyses of the predictive value of these miRNAs compared to ALS-like diseases is a necessary next step.

Link to Paper

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