Ammonia
May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS number: 7664-41-7
NIOSH REL: 25 ppm (18 mg/m3) TWA, 35 ppm (27 mg/m3) STEL
Current OSHA PEL: 50 ppm (35 mg/m3) TWA
1989 OSHA PEL: 35 ppm (27 mg/m3) STEL
1993-1994 ACGIH TLV: 25 ppm (17 mg/m3) TWA, 35 ppm (24 mg/m3) STEL
Description of substance: Colorless gas with a pungent, suffocating odor.
LEL: 15% (10% LEL, 15,000 ppm)
Original (SCP) IDLH: 500 ppm
Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by AIHA [1971] that 300 to 500 ppm for 30 to 60 minutes have been reported as a maximum short exposure tolerance [Henderson and Haggard 1943]. AIHA [1971] also reported that 5,000 to 10,000 ppm are reported to be fatal [Mulder and Van der Zahm 1967] and exposures for 30 minutes to 2,500 to 6,000 ppm are considered dangerous to life [Smyth 1956].
Existing short-term exposure:
1988 American Industrial Hygiene Association (AIHA) Emergency Response Planning Guidelines (ERPGs)
- ERPG-1: 25 ppm
- ERPG-2: 200 ppm
- ERPG-3: 1,000 ppm
National Research Council [NRC 1987] Emergency Exposure Guidance Levels (EEGLs)
- 1-hour EEGL: 100 ppm
- 24-hour EEGL: 100 ppm
U.S. Navy Standards [U.S. Bureau of Ships 1962] Maximum allowable concentrations (MACs):
- Continuous exposure (60 days): 25 ppm
- 1 hour: 400 ppm
ACUTE TOXICITY DATA
Lethal concentration data:
Species | Reference | LC50(ppm) | LCLo(ppm) | Time | Adjusted 0.5-hr LC (CF) | Derived Value |
---|---|---|---|---|---|---|
Rat | Alarie 1981 | 40,300 | —– | 10 min | 23,374 ppm (0.58) | 2,337 ppm |
Rat | Alarie 1981 | 28,595 | —– | 20 min | 23,448 ppm (0.82) | 2,335 ppm |
Rat | Alarie 1981 | 20,300 | —– | 40 min | 23,345 ppm (1.15) | 2,335 ppm |
Rat | Alarie 1981 | 11,590 | —– | 1 hr | 16,342 ppm (1.41) | 1,634 ppm |
Rat | Back et al. 1972 | 7,338 | —– | 1 hr | 10,347 ppm (1.41) | 1,035 ppm |
Mouse | Back et al. 1972 | 4,837 | —– | 1 hr | 6,820 ppm (1.41) | 682 ppm |
Rabbit | Boyd et al. 1944 | 9,859 | —– | 1 hr | 13,901 ppm (1.41) | 1,309 ppm |
Cat | Boyd et al. 1944 | 9,859 | —– | 1 hr | 13,901 ppm (1.41) | 1,309 ppm |
Rat | Deichmann and Gerarde 1969 | 2,000 | —– | 4 hr | 5,660 ppm (2.83) | 566 ppm |
Mammal | Flury 1928 | —– | 5,000 | 5 min | 2,050 ppm (0.41) | 205 ppm |
Mouse | Kapeghian et al. 1982 | 4,230 | —– | 1 hr | 5,964 ppm (1.41) | 596 ppm |
Human | Tab Biol Per 1933 | —– | 5,000 | 5 min | 2,050 ppm (0.41) | 205 ppm |
*Note: Conversion factor (CF) was determined with “n” = 2.0 [ten Berge et al. 1986].
Other animal data:RD50 (mouse), 303 ppm [Appelman et al. 1982].
Other human data: The maximum short exposure tolerance has been reported as being 300 to 500 ppm for 0.5 to 1 hour [Henderson and Haggard 1943]. A change in respiration rate and moderate to severe irritation has been reported in 7 subjects exposed to 500 ppm for 30 minutes [Silverman et al. 1946].
Revised IDLH: 300 ppm Basis for revised IDLH: The revised IDLH for ammonia is 300 ppm based on acute inhalation toxicity data in humans [Henderson and Haggard 1943; Silverman et al. 1946]. |
REFERENCES:
- AIHA [1971]. Anhydrous ammonia. In: Hygienic guide series. Am Ind Hyg Assoc J 32:139-142.
- Alarie Y [1981]. Dose-response analysis in animal studies: prediction of human responses. Environ Health Perspect 42:9-13.
- Appelman LM, ten Barge WF, Reuzel PGJ [1982]. Acute inhalation toxicity study of ammonia in rats with variable exposure periods. Am Ind Hyg Assoc J 43:662-665.
- Back KC, Thomas AA, MacEwen JD [1972]. Reclassification of materials listed as transportation health hazards. Wright-Patterson Air Force Base, OH: 6570th Aerospace Medical Research Laboratory, Report No. TSA-20-72-3, pp. A-172 to A-173.
- Boyd EM, MacLachlan ML, Perry WF [1944]. Experimental ammonia gas poisoning in rabbits and cats. J Ind Hyg Toxicol 26:29-34.
- Deichmann WB, Gerarde HW [1969]. Trifluoroacetic acid (3FA). In: Toxicology of drugs and chemicals. New York, NY: Academic Press, Inc., p. 607.
- Flury F [1928]. Moderne gewerbliche vergiftungen in pharmakologisch-toxikologischer hinsicht (Pharmacological-toxicological aspects of intoxicants in modern industry). Arch Exp Pathol Pharmakol 138:65-82 (translated).
- Henderson Y, Haggard HW [1943]. Noxious gases. 2nd ed. New York, NY: Reinhold Publishing Corporation, p. 126.
- Kapeghian JC, Jones AB, Mincer HH, Verlangieri AJ, Waters IW [1982]. The toxicity of ammonia gas in the mouse. Fed Proc 41:1568 [Abstract #7586].
- Mulder JS, Van der Zahm HO [1967]. Fatal case of ammonium poisoning. Tydschrift Voor Sociale Geneeskunde (Amsterdam) 45:458-460 (translated).
- NRC [1987]. Emergency and continuous exposure guidance levels for selected airborne contaminants. Vol. 7. Ammonia, hydrogen chloride, lithium bromide, and toluene. Washington, DC: National Academy Press, Committee on Toxicology, Board on Toxicology and Environmental Health Hazards, Commission on Life Sciences, National Research Council, pp. 7-15.
- Silverman L, Whittenberger JL, Muller J [1946]. Physiological response of man to ammonia in low concentrations. J Ind Hyg Toxicol 31:74-78.
- Smyth HF Jr [1956]. Improved communication: hygienic standards for daily inhalation. Am Ind Hyg Assoc Q 17(2):129-185.
- Tab Biol Per [1933]; 3:231-296 (in German).
- ten Berge WF, Zwart A, Appelman LM [1986]. Concentration-time mortality response relationship of irritant and systematically acting vapours and gases. J Haz Mat 13:301-309.
- U.S. Bureau of Ships [1962]. Submarine atmosphere habitability data book. AVSHIPS 250-649-1. Rev. 1. Washington, DC: U.S. Department of the Navy, U.S. Bureau of Ships, p. 629.