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Volume 30, Number 6—June 2024
Synopsis

Deciphering Unexpected Vascular Locations of Scedosporium spp. and Lomentospora prolificans Fungal Infections, France

Carole VignalsComments to Author , Joseph Emmerich, Hugues Begueret, Dea Garcia-Hermoso, Guillaume Martin-Blondel, Adela Angoulvant, Damien Blez, Patrick Bruneval, Sophie Cassaing, Emilie Catherinot, Pierre Cahen, Cécile Moluçon-Chabrot, Carole Chevenet, Laurence Delhaes, Lélia Escaut, Marie Faruch, Frédéric Grenouillet, Fabrice Larosa, Lucie Limousin, Elisabeth Longchampt, François Mellot, Céline Nourrisson, Marie-Elisabeth Bougnoux, Olivier Lortholary, Antoine Roux, Laura Rozenblum, Mathilde Puges, Fanny Lanternier, and Didier Bronnimann
Author affiliations: Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France (C. Vignals, H. Begueret, L. Delhaes, M. Puges, D. Bronnimann); Hôpital Saint-Joseph, Paris, France (J. Emmerich); Institut Pasteur, Paris (D. Garcia-Hermoso, M.-E. Bougnoux, O. Lortholary, F. Lanternier); Centre Hospitalier Universitaire de Toulouse, Toulouse, France (G. Martin-Blondel, S. Cassaing, M. Faruch); Hôpital Bicêtre, Le Kremlin-Bicêtre, France (A. Angoulvant, L. Escaut); Hôpital Européen Georges Pompidou, Paris (D. Blez, P. Bruneval); Hôpital Foch, Suresnes, France (E. Catherinot, P. Cahen, L. Limousin, E. Longchampt, F. Mellot, A. Roux); Centre hospitalier universitaire de Clermont-Ferrand, Clermont-Ferrand, France (C. Moluçon-Chabrot, C. Chevenet, C. Nourrisson); Centre hospitalier universitaire de Besançon, Besançon, France (F. Grenouillet); Centre Hospitalier Universitaire de Dijon, Dijon, France (F. Larosa); Hôpital Necker-enfants malades AP-HP, Paris (M.-E. Bougnoux, O. Lortholary, F. Lanternier); Hôpital Pitié-Salpêtrière AP-HP, Paris (L. Rozenblum)

Main Article

Figure 5

Radiologic and histopathologic analysis of thoracic aortitis in case-patient 6 in study of unexpected vascular locations of Scedosporium spp. and Lomentospora prolificans fungal infections, France. A) Thoracic computed tomography scan showing sacciform aneurysm of ascending aorta (star). B) Thoracic computed tomography scan 21 days later showing the rapidly growing aneurysm (star). C) Hematoxylin-eosin-saffron stain of thoracic aorta section. Star indicates thoracic aorta wall dissection. Triangle indicates tunica media. Scale bar indicates 1 mm. D) Grocott-Gomori methenamine silver stain of thoracic aorta section. Star indicates septate fungal hyphae invading the thoracic aorta tunica media. Triangle indicates thrombus containing septate fungal hyphae. Scale bar indicates 100 μm. Data are from the Scedosporiosis/lomentosporiosis Observational Study (12).

Figure 5. Radiologic and histopathologic analysis of thoracic aortitis in case-patient 6 in study of unexpected vascular locations of Scedosporium spp. and Lomentospora prolificans fungal infections, France. A) Thoracic computed tomography scan showing sacciform aneurysm of ascending aorta (star). B) Thoracic computed tomography scan 21 days later showing the rapidly growing aneurysm (star). C) Hematoxylin-eosin-saffron stain of thoracic aorta section. Star indicates thoracic aorta wall dissection. Triangle indicates tunica media. Scale bar indicates 1 mm. D) Grocott-Gomori methenamine silver stain of thoracic aorta section. Star indicates septate fungal hyphae invading the thoracic aorta tunica media. Triangle indicates thrombus containing septate fungal hyphae. Scale bar indicates 100 μm. Data are from the Scedosporiosis/lomentosporiosis Observational Study (12).

Main Article

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