Powassan: Causes and How It Spreads

Key Points

  • Powassan virus disease (Powassan) is caused by a virus primarily spread to people through the bite of infected ticks.
  • Powassan is maintained in the environment between ticks and animals.
  • People do not spread the infection except in rare cases through blood transfusions.
Blacklegged tick on a white fingernail

Primary cause

Powassan is caused by either Powassan virus or deer tick virus. These viruses are often referred to as lineage 1 and lineage 2 Powassan virus.

The two virus lineages are very similar but different in the specific types of ticks that spread the virus to people.

How it spreads

  • Powassan virus is spread to people primarily through the bite of an infected tick.
  • Three types of Ixodes species ticks spread Powassan virus and are primarily found in the eastern half of the United States.
  • Ticks become infected when they feed on groundhogs, squirrels, mice, or other rodents that have the virus in their blood.
  • People do not develop high enough levels of the virus in their blood to infect biting ticks. As a result, people are considered "dead-end" hosts for Powassan virus.
  • The virus is not transmitted from person-to-person, except rarely by blood transfusion.
  • Because the virus can be transmitted through blood, persons who were recently diagnosed with Powassan virus infection should not donate blood or bone marrow for 120 days following infection.
  • Prevent getting sick with Powassan virus by preventing tick bites.