Appendix: Prophylaxis and Screening for Prevention of Respiratory Illness in Neonatal Intensive Care Unit Patients: A Systematic Review
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Table 1. Search of MEDLINE® for Guidelines
# | Search History | Results |
---|---|---|
1 | exp Respiratory Tract Infections/ | 244,589 |
2 | exp Virus Diseases/ | 599,053 |
3 | 1 and 2 | 52,335 |
4 | exp Respiratory Syncytial Virus Infections/ | 3,517 |
5 | 3 or 4 | 54,539 |
6 | limit 5 to (english language and humans and (guideline or practice guideline)) | 156 |
7 | limit 6 to (systematic reviews) | 130 |
8 | limit 7 to (all infant (birth to 23 months)) | 61 |
Table 2. Search of Cochrane Library for Guidelines
# | Search History | Results |
---|---|---|
1 | (virus diseases):ti,ab,kw and (respiratory tract infections):ti,ab,kw | 153 |
2 | (respiratory syncytial virus):ti,ab,kw | 361 |
3 | 1 or 2, in Cochrane Reviews and Health Technology Assessments | 25 |
Table 3. Search of National Guideline Clearinghouse (NGC) for Guidelines
Keyword | Results |
---|---|
respiratory viral infection | 140 |
limit to infant age group | 64 |
Table 4. Search of American Academy of Pediatrics (AAP) for Guideline
Search History | Results |
---|---|
Browsed http://pediatrics.aappublications.org/site/aappolicy/index.xhtml | 49 |
Table 5. Search of Association for Professionals in Infection Control and Epidemiology (APIC) for Guidelines
Search History | Results |
---|---|
Browsed http://www.apic.org | 3 |
Table 6. Search of CDC and Healthcare Infection Control Practices Advisory Committee (HICPAC) for Guidelines
Search History | Results |
---|---|
Browsed http://www.cdc.gov/hicpac | 2 |
Table 7. Search of Infectious Diseases Society of America (IDSA) for Guidelines
Search History | Results |
---|---|
Browsed http://www.idsociety.org | 1 |
Table 8. Search of National Institute for Health and Clinical Excellence (NICE) for Guidelines
Search History | Results |
---|---|
Browsed http://guidance.nice.org.uk | 1 |
Table 9. Search of Scottish Intercollegiate Guidelines Network (SIGN) for Guidelines
Search History | Results |
---|---|
Browsed http://sign.ac.uk/guidelines/index.html | 0 |
Table 10. Search of Society for Healthcare Epidemiology of America (SHEA) for Guidelines
Search History | Results |
---|---|
Browsed http://www.shea-online.org | 1 |
Table 11. Primary Viral Illness Search of MEDLINE®
Search History | Results through 12/2012 | Results 12/2012 – 7/5/2016 | Results 7/5/2016 11/18/2022 |
---|---|---|---|
exp Intensive Care Units, Neonatal/ or exp Intensive Care, Neonatal/ OR Infant, Newborn/ AND (exp Respiratory Tract Infections/ AND exp Virus Diseases/) OR exp Respiratory Syncytial Virus Infections/ or exp Respiratory Syncytial Viruses/ AND exp Infection Control/ OR exp Cross Infection/ OR exp Communicable Disease Control/ NOT Exp Animals/ NOT exp humans/ AND publication dates English |
341 | 158 | 631 |
Table 12. Primary Viral Illness Search of EMBASE
Search History | Results through 12/2012 | Results 12/2012 – 7/5/2016 | Results 7/5/2016 11/18/2022 |
---|---|---|---|
(Exp respiratory tract infection/ and exp virus infection/) OR Exp respiratory syncytial virus infection/ OR exp respiratory syncytial pneumovirus/ AND Exp newborn intensive care/ or exp newborn/ AND Exp infection control/ or exp hospital infection/ or exp cross infection/ NOT Exp Animal/ NOT exp human/ AND publication dates English |
16 | 9 | 52 |
Table 13. Primary Viral Illness Search of Cochrane Library
Search History | Results through 12/2012 | Results 12/2012 – 7/5/2016 | Results 7/5/2016 11/18/2022 |
---|---|---|---|
Publication date July 2016 – |
71 | 12 | 4 |
Table 14. Primary Viral illness Search of CINAHL
Search History | Results through 12/2012 | Results 12/2012 – 7/5/2016 | Results 7/5/2016 11/18/2022 |
---|---|---|---|
((MH “Virus Diseases+”) AND (MH “Respiratory Tract Infections”)) OR (MH “Respiratory Syncytial Virus Infections”) OR (MH “Respiratory Syncytial Viruses”) AND (MH “Intensive Care Units, Neonatal”) OR (MH “Intensive Care, Neonatal”) OR (MH “Infant, Newborn+”) AND Limit to english language; exclude MEDLINE records; Published Date- |
71 | 12 | 86 |
Table 15 Primary Varicella Search of MEDLINE®
# | Search History | Results through 12/2012 | Results 12/2012 – 7/5/2016 | Results 12/2012 – 7/5/2016 |
---|---|---|---|---|
1 | exp Intensive Care Units, Neonatal/ or exp Intensive Care, Neonatal/ | 10,468 | 15,068 | 22,079 |
2 | exp Infant, Newborn/ | 440,039 | 541,022 | 655,642 |
3 | 1 or 2 | 440,773 | 542,198 | 657,262 |
4 | exp Chickenpox/ or exp Herpesvirus 3, Human/ | 9,087 | 11,297 | 13,218 |
5 | 3 and 4 | 758 | 893 | 974 |
6 | exp Infection Control/ | 43,472 | 55,607 | 69,291 |
7 | exp Cross Infection/ | 39,337 | 51,355 | 63,616 |
8 | exp Communicable Disease Control/ | 207,130 | 288,187 | 395,159 |
9 | 6 or 7 or 8 | 236,616 | 326,701 | 443,885 |
10 | 5 and 9 | 95 | 123 | 156 |
11 | limit 10 to (english language and humans) | 79 | 108 | 139 |
12 | (201607* OR 201608* OR 201609* OR 201610* OR 201611* OR 201612* OR 2017* OR 2018* OR 2019* OR 2020* OR 2021* OR 2022*).dt | – | 22 | 28 |
Table 16. Primary Varicella Search of EMBASE
# | Search History | Results through 12/2012 | Results 12/2012 – 7/5/2016 | Results 12/2012 – 7/5/2016 |
---|---|---|---|---|
1 | Exp newborn intensive care/ or exp newborn/ | 434,871 | 351,852 | 676,874 |
2 | Exp chickenpox/ or exp varicella zoster virus/ | 15,108 | 16,152 | 27,589 |
3 | 1 and 2 | 647 | 538 | 966 |
4 | Exp infection control/ or exp hospital infection/ or exp cross infection/ | 90,076 | 120,312 | 184,646 |
5 | 3 and 4 | 29 | 28 | 35 |
6 | Limit 5 to (english language and humans) | 21 | 22 | 27 |
7 | publication dates | – | 4 | 1 |
Table 17. Primary Varicella Search of Cochrane Library
# | Search History | Results through 12/2012 | Results 12/2012 – 7/5/2016 | Results 12/2012 – 7/5/2016 |
---|---|---|---|---|
1 | MeSH descriptor Intensive Care, Neonatal explode all trees | 253 | 307 | 139 |
2 | MeSH descriptor Intensive Care Units, Neonatal explode all trees | 401 | 559 | 95 |
3 | MeSH descriptor Infant, Newborn explode all trees | 11,218 | 14,329 | 207 |
4 | 1 or 2 or 3 | 11,250 | 14,370 | 253 |
5 | MeSH descriptor Cross Infection explode all trees | 1,277 | 1,477 | 1,392 |
6 | MeSH descriptor Infection Control explode all trees | 1,080 | 1,293 | 1,631 |
7 | MeSH descriptor Communicable Disease Control explode all trees | 3,811 | 5,096 | 72 |
8 | 5 or 6 or 7 | 4,796 | 6,267 | 1,713 |
9 | 4 and 8 | 366 | 478 | 150 |
10 | MeSH descriptor Chickenpox explode all trees | 154 | 139 | 3 |
11 | MeSH descriptor Herpesvirus 3, Human explode all trees | 116 | 133 | 10 |
12 | 10 or 11 | 223 | 226 | 12 |
13 | 9 and 12 | 6 | 3 | 3 |
14 | Limit to 2016-current | – | 1 | 3 |
Table 18. Primary Varicella Search of CINAHL
# | Search History | Results through 12/2012 | Results 12/2012 – 7/5/2016 | Results 12/2012 – 7/5/2016 |
---|---|---|---|---|
1 | (MH “Intensive Care, Neonatal+”) or (MH “Intensive Care Units, Neonatal”) | 6,428 | 10,033 | 19,863 |
2 | (MH “Chickenpox”) or (MH “Herpesviruses+”) | 2,160 | 3,144 | 8,287 |
3 | MH “Infection Control+” | 29,526 | 42,696 | 80,711 |
4 | MH “Cross Infection+” | 14,160 | 21,838 | 34,914 |
5 | MH “Communicable Diseases” | 4,254 | 5,884 | 12,383 |
6 | 3 or 4 or 5 | 40,673 | 59,588 | 112,404 |
7 | MH “Infant, Newborn+” | 49,610 | 66,361 | 152,560 |
8 | 1 or 7 | 50,951 | 69,458 | 157,914 |
9 | 2 and 6 and 8 | 29 | 37 | 63 |
10 | Limit to publication dates | – | 3 | 13 |
Table 19. Primary Pertussis Search of MEDLINE
# | Search History | Results through 12/2012 | Results 12/2012 – 7/5/2016 | Results 12/2012 – 7/5/2016 |
---|---|---|---|---|
1 | exp Intensive Care Units, Neonatal/ or exp Intensive Care, Neonatal/ | 10,468 | 15,068 | 22,079 |
2 | exp Infant, Newborn/ | 440,039 | 541,022 | 655,642 |
3 | 1 or 2 | 440,773 | 542,198 | 657,262 |
4 | exp Infection Control/ | 43,472 | 55,607 | 69,291 |
5 | exp Cross Infection/ | 39,337 | 51,355 | 63,616 |
6 | exp Communicable Disease Control/ | 207,130 | 288,187 | 395,159 |
7 | 4 or 5 or 6 | 236,616 | 326,701 | 443,885 |
8 | exp Whooping Cough/ | 5,724 | 7,591 | 8,996 |
9 | exp Bordetella/ or exp Bordetella Infections/ or exp Bordetella pertussis/ | 9,661 | 11,920 | 13,711 |
10 | 8 or 9 | 9,661- | 11,920 | 13,711 |
11 | 3 and 7 and 10 | 237 | 362 | 533 |
12 | limit 11 to (english language and humans) | 177 | 292 | 450 |
13 | publication year | – | 93 | 142 |
Table 20. Primary Pertussis Search of EMBASE
# | Search History | Results through 12/2012 | Results 12/2012 – 7/5/2016 | Results 12/2012 – 7/5/2016 |
---|---|---|---|---|
1 | Exp newborn intensive care/ or exp newborn/ | 434,871 | 351,852 | 676,874 |
2 | Exp bordetella pertussis/ or exp pertussis/ | 12,291 | 11,227 | 22518 |
3 | Exp infection control/ or exp hospital infection/ or exp cross infection/ | 90,076 | 120,312 | 184,646 |
4 | 1 and 2 | 634 | 561 | 1,204 |
5 | 3 and 4 | 41 | 45 | 56 |
6 | Limit 5 to (english language and humans) | 31 | 38 | 44 |
7 | publication year | – | 7 | 2 |
Table 21. Primary Pertussis Search of Cochrane Library
# | Search History | Results through 12/2012 | Results 12/2012 – 7/5/2016 | Results 12/2012 – 7/5/2016 |
---|---|---|---|---|
1 | MeSH descriptor Intensive Care, Neonatal explode all trees | 253 | 307 | 139 |
2 | MeSH descriptor Intensive Care Units, Neonatal explode all trees | 401 | 559 | 95 |
3 | MeSH descriptor Infant, Newborn explode all trees | 11,218 | 14,329 | 207 |
4 | 1 or 2 or 3 | 11,250 | 14,370 | 253 |
5 | MeSH descriptor Cross Infection explode all trees | 1,277 | 1,477 | 1,392 |
6 | MeSH descriptor Infection Control explode all trees | 1,080 | 1,293 | 1,631 |
7 | MeSH descriptor Communicable Disease Control explode all trees | 3,811 | 5,096 | 72 |
8 | 5 or 6 or 7 | 4,796 | 6,267 | 1,713 |
9 | 4 and 8 | 366 | 478 | 150 |
10 | MeSH descriptor Bordetella pertussis explode all trees | 116 | 118 | 5 |
11 | MeSH descriptor Whooping Cough explode all trees | 203 | 221 | 10 |
12 | MeSH descriptor Bordetella explode all trees | 117 | 119 | 6 |
13 | MeSH descriptor Bordetella Infections explode all trees | 203 | 221 | 6 |
14 | 10 or 11 or 12 or 13 | 255 | 274 | 12 |
15 | 9 and 14 | 4 | 8 | 5 |
16 | Publication Year | – | 2 | 3 |
Table 22. Primary Pertussis Search of CINAHL
# | Search History | Results through 12/2012 | Results 12/2012 – 7/5/2016 | Results 12/2012 – 7/5/2016 |
---|---|---|---|---|
1 | (MH “Intensive Care, Neonatal+”) or (MH “Intensive Care Units, Neonatal”) or (MH “Infant, Newborn+”) | 50,951 | 72,510 | 157,914 |
2 | (MH “Bordetella Pertussis”) or (MH “Whooping Cough”) | 707 | 1,186 | 2,160 |
3 | MH “Infection Control+” | 29,526 | 42,696 | 80,711 |
4 | MH “Cross Infection+” | 14,160 | 21,838 | 34,914 |
5 | MH “Communicable Diseases” | 4,254 | 5,884 | 12,383 |
6 | 3 or 4 or 5 | 40,673 | 59,588 | 112,404 |
7 | 1 and 2 and 6 | 41 | 77 | 134 |
8 | Limit 7 to (english language; exclude MEDLINE records) | 10 | 19 | 37 |
9 | Limit to year | – | 8 | 11 |
Criteria for excluding studies from the literature review are:
- Not relevant to key questions
- Not primary research
- Meeting abstract only
- No full text available
- Not in English
- Not 100% of patients are in NICU, with no subpopulation analysis
- Mixed patient population without NICU subgroups or infant location not specified
- Methods paper on HAI surveillance only
- Studies examining interventions of any kind (single or multi-intervention) unless they provide a clear description of the interventions and statistical analysis comparing time points before and after the intervention
- N<10 exposed
- Studies examining immunizations only