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The 6- to 9-month RIPE TB treatment regimens consist of

• Rifampin (RIF),
• Isoniazid (INH),
• Pyrazinamide (PZA), and
• Ethambutol (EMB)

RIPE regimens for treating TB disease have an intensive phase of 2 months, followed by a continuation phase of either 4 or 7 months (total of 6 to 9 months for treatment).

While all the regimens are effective, the 6-month RIPE TB regimen for the treatment of drug-susceptible pulmonary TB can be used in most patients.

• Intensive phase:

- Isoniazid (INH), rifampin (RIF), pyrazinamide (PZA), and ethambutol (EMB) 7 days a week for 56 doses (8 weeks)

OR

- Isoniazid (INH), rifampin (RIF), pyrazinamide (PZA), and ethambutol (EMB) 5 days a week for 40 doses (8 weeks)

• Continuation phase:

- Isoniazid (INH) and rifampin (RIF) 7 days a week for 126 doses (18 weeks)

OR

- Isoniazid (INH) and rifampin (RIF) 5 days a week for 90 doses (18 weeks)