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Table 3 – STI Treatment Guidelines

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Vaccines for Preventing Hepatitis A Infection

Table 3
Vaccine Trade name (manufacturer) Age group (yrs) Dose Route Schedule Booster
Hep A inactivated (2 doses) Havrix (GlaxoSmithKline) 1–18 0.5 mL (720 ELISA units inactivated HAV) IM 0, 6–12 mos None
≥19 1 mL (1,440 ELISA units inactivated HAV IM 0, 6–12 mos None
Hep A inactivated (2 doses) Vaqta (Merck) 1–18 0.5 mL (25 units HAV antigen) IM 0, 6–18 mos None
≥19 1 mL (50 units HAV antigen) IM 0, 6–18 mos None
Combined Hep A and Hep B* (3 doses) Twinrix (GlaxoSmithKline) ≥18 (primary) 1 mL (720 ELISA units inactivated plus 20 µg HBsAg IM 0, 1, 6 mos None
≥18 (accelerated) 1 mL (720 ELISA units inactivated plus 20 µg HBsAg IM 0, 7, 21–30 days 12 mos

Source: Nelson NP, Weng MK, Hofmeister MG, et al. Prevention of hepatitis A virus infection in the United States: recommendations of the Advisory Committee on Immunization Practices, 2020. MMWR Recomm Rep 2020;69(No. RR-5).

Abbreviations: ELISA = enzyme-linked immunosorbent assay; HAV = hepatitis A virus; HBsAg = hepatitis B surface antigen; Hep A = hepatitis A; Hep B = hepatitis B; IM= intramuscular.

* Combined Hep A and Hep B vaccine (Twinrix) should not be used as postexposure prophylaxis.

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