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Sexually Transmitted Infections Treatment Guidelines, 2021
On March 6, 2026, the FDA announced they are allowing the temporary importation of Lentocilin© due to the ongoing limited availability and extended recovery of Bicillin® L-A.
- Information for health care providers on the administration of Lentocilin© .
- Further details and priority actions for health departments and healthcare providers
- Availability of STI testing and treatment products
CDC’s Sexually Transmitted Infections (STI) Treatment Guidelines, 2021 provides current evidence-based prevention, diagnostic and treatment recommendations that replace the 2015 guidance. The recommendations are intended to be a source for clinical guidance. Healthcare providers should always assess patients based on their clinical circumstances and local burden.
View the full STI Treatment Guidelines.
Access print-friendly versions of the wall chart, pocket guide, and guidelines.
Explore STD trainings, technical assistance, clinical consultation services, and more.
View tables of screening recommendations by disease or by population.
- Suspected Gonorrhea Treatment Failure Consultation Form
- Mycoplasma genitalium Treatment Failure Registry
- Customizable Announcement
- Screening Recommendations
- Tables of Evidence
- A Guide to Taking a Sexual History
- Expedited Partner Therapy
- Availability of STI Testing & Treatment Products
- Prenatal Syphilis Screening Laws
- National STD Curriculum