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Table 20. Total Syphilis* — Reported Cases and Rates of Reported Cases by State/Territory and Region in Alphabetical Order, United States, 2018–2022

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Table 20. Total Syphilis* — Reported Cases and Rates of Reported Cases by State/Territory and Region in Alphabetical Order, United States, 2018–2022
State/Territory Cases Rates per 100,000 Population
2018 2019 2020 2021 2022 2018 2019 2020 2021 2022
Alabama 1,285 1,634 1,518 2,173 3,088 26.3 33.3 30.2 43.1 60.9
Alaska 113 242 361 447 424 15.3 33.1 49.2 61.0 57.8
Arizona 3,251 4,025 4,461 6,331 7,496 45.3 55.3 62.4 87.0 101.9
Arkansas 964 1,106 1,243 2,403 2,817 32.0 36.6 41.3 79.4 92.5
California 25,253 28,811 26,414 31,280 33,346 63.8 72.9 66.8 79.7 85.4
Colorado 1,085 1,434 1,785 2,303 3,100 19.0 24.9 30.9 39.6 53.1
Connecticut 264 482 536 889 760 7.4 13.5 14.9 24.7 21.0
Delaware 129 216 222 295 435 13.3 22.2 22.4 29.4 42.7
District of Columbia 764 1,085 988 870 1,275 108.8 153.7 143.3 129.8 189.8
Florida 10,701 12,121 12,416 16,439 18,838 50.2 56.4 57.6 75.5 84.7
Georgia 4,937 5,685 5,595 6,711 7,361 46.9 53.5 52.2 62.1 67.5
Hawaii 210 252 397 643 606 14.8 17.8 27.3 44.6 42.1
Idaho 134 149 184 270 351 7.6 8.3 10.0 14.2 18.1
Illinois 4,472 4,511 4,568 5,124 5,734 35.1 35.6 35.7 40.4 45.6
Indiana 985 993 1,349 1,980 2,129 14.7 14.7 19.9 29.1 31.2
Iowa 286 359 501 763 886 9.1 11.4 15.7 23.9 27.7
Kansas 495 565 539 803 958 17.0 19.4 18.3 27.4 32.6
Kentucky 881 1,096 1,143 1,559 2,032 19.7 24.5 25.4 34.6 45.0
Louisiana 2,744 2,744 2,497 3,480 4,453 58.9 59.0 53.6 75.3 97.0
Maine 147 136 81 135 154 11.0 10.1 5.9 9.8 11.1
Maryland 2,536 2,779 2,683 NR 2,798 42.0 46.0 43.4 — 45.4
Massachusetts 1,305 1,844 1,658 2,051 2,444 18.9 26.8 23.6 29.4 35.0
Michigan 1,692 1,905 2,059 2,671 2,824 16.9 19.1 20.4 26.6 28.1
Minnesota 918 1,127 1,098 1,465 1,839 16.4 20.0 19.2 25.7 32.2
Mississippi 1,454 2,006 2,131 2,605 3,260 48.7 67.4 72.0 88.3 110.9
Missouri 1,914 2,188 2,332 3,780 4,176 31.2 35.7 37.9 61.3 67.6
Montana 104 140 101 225 629 9.8 13.1 9.3 20.4 56.0
Nebraska 219 291 269 476 653 11.4 15.0 13.7 24.2 33.2
Nevada 2,000 2,356 2,218 3,065 3,610 65.9 76.5 71.4 97.5 113.6
New Hampshire 137 135 120 145 175 10.1 9.9 8.7 10.4 12.5
New Jersey 1,777 2,085 2,386 3,389 3,615 19.9 23.5 25.7 36.6 39.0
New Mexico 812 1,294 1,496 2,069 2,469 38.8 61.7 70.6 97.8 116.8
New York 10,183 10,500 10,613 13,106 13,685 52.1 54.0 52.5 66.1 69.5
North Carolina 2,989 3,369 3,714 5,030 6,587 28.8 32.1 35.6 47.7 61.6
North Dakota 84 97 91 106 128 11.1 12.7 11.7 13.7 16.4
Ohio 1,909 2,005 2,457 3,958 5,300 16.3 17.2 20.8 33.6 45.1
Oklahoma 1,137 1,749 1,888 3,003 3,501 28.8 44.2 47.7 75.3 87.1
Oregon 1,032 1,245 1,320 2,010 2,393 24.6 29.5 31.2 47.3 56.4
Pennsylvania 2,414 2,764 2,898 3,816 4,486 18.8 21.6 22.3 29.4 34.6
Rhode Island 284 423 315 567 516 26.9 39.9 28.7 51.8 47.2
South Carolina 1,152 1,306 1,681 2,079 2,473 22.7 25.4 32.8 40.1 46.8
South Dakota 74 86 128 924 1,947 8.4 9.7 14.4 103.2 214.0
Tennessee 1,726 2,226 2,463 3,181 3,874 25.5 32.6 35.6 45.6 54.9
Texas 12,974 12,659 15,362 21,480 26,985 45.2 43.7 52.7 72.7 89.9
Utah 423 431 351 531 673 13.4 13.4 10.7 15.9 19.9
Vermont 29 24 23 16 5 4.6 3.8 3.6 2.5 0.8
Virginia 2,039 2,071 1,953 2,205 2,962 23.9 24.3 22.6 25.5 34.1
Washington 1,911 2,186 2,079 3,366 4,410 25.4 28.7 27.0 43.5 56.6
West Virginia 185 277 407 536 610 10.2 15.5 22.7 30.1 34.4
Wisconsin 509 569 835 1,615 1,919 8.8 9.8 14.2 27.4 32.6
Wyoming 42 42 32 43 66 7.3 7.3 5.5 7.4 11.4
US TOTAL 115,064 129,825 133,959 176,733 207,255 35.2 39.6 40.4 53.2 62.2
    Northeast 16,540 18,393 18,630 24,114 25,840 29.5 32.9 32.3 42.2 45.3
   Midwest 13,557 14,696 16,226 23,665 28,493 19.8 21.5 23.5 34.4 41.4
   South 48,597 54,129 57,904 76,371 93,349 39.0 43.1 45.9 60.0 72.5
   West 36,370 42,607 41,199 52,583 59,573 46.6 54.4 52.4 66.8 75.7
American Samoa 0 0 0 0 0 0.0 0.0 0.0 0.0 0.0
Commonwealth of the Northern Mariana Islands 2 2 2 2 4 3.8 3.8 3.9 3.9 7.8
Guam 30 31 21 22 19 17.9 18.4 12.5 13.0 11.2
Puerto Rico 1,089 949 829 1,132 1,424 33.1 29.7 25.2 34.7 44.2
US Virgin Islands NR 45 40 42 33 — 42.2 37.6 39.7 31.3
TERRITORIES TOTAL 1,121 1,027 892 1,198 1,480 31.4 28.8 24.4 32.9 41.2
TOTAL 116,185 130,852 134,851 177,931 208,735 35.1 39.4 40.2 53.0 62.0
* Includes cases of congenital syphilis
NR = No report.
NOTE: See Technical Notes for more information on syphilis case reporting and on interpreting case counts and rates in US territories. This report includes data from years that coincide with the COVID-19 pandemic, which introduced uncertainty and difficulty in interpreting case data. See Impact of COVID-19 on STIs for more information. Due to a network security incident in December 2021, the Maryland Department of Health could not finalize their 2021 STI case notification data. Although 2021 data from Maryland are included in national and regional case counts and rates displayed in this table, state-specific data have been suppressed.

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