ORIGINAL RESEARCH

Factors Related to Coronary Heart Disease Risk Among Men: Validation of the Framingham Risk Score

Exclusion and Inclusion Criteria for Aerobics Center Longitudinal Study (ACLS).		Population Size After Each Criterion is Applied
1	ACLS men with complete FRS data aged 30 to 74 years	38,469
2	Free of CHD at baseline, BMI ≥ 18.5 kg/m2	36,629
3	Free of cancer at baseline	35,603
4	Men with at least one year of follow-up	34,557
5a	Free of coronary heart disease during the 12-year follow-up	33,970
5b	Experienced a coronary heart disease event during the 12-year follow-up period	587

Abbreviations: FRS, Framingham Heart Study; CHD, coronary heart disease; BMI, body mass index.

Figure 1. Study flow and Aerobic Center Longitudinal Study inclusion criteria depicting final sample size and coronary heart disease event frequency. Men with complete Framingham Risk Score data and body mass index ≥ 18.5 kg/m² were included in the analysis. Abbreviations: FRS, Framingham Heart Study; CHD, coronary heart disease; BMI, body mass index.

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Receiver Operating Characteristic Curve Association Statistics	Area Under the Curve	Standard Error	95% Confidence Interval
Model	0.7697	0.00889	0.7523	0.7871

Figure 2. Receiver operating characteristic curve representing the predictive ability of the Framingham Risk Score applied to the Aerobics Center Longitudinal Study cohort after a 12-year follow-up. The Hosmer-Lemeshow C statistic is represented by the Area Under the Curve (C = 0.7697, 95% confidence interval, 0.7523–0.7871).

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