Funding for Long-Acting Injectables for the Treatment of HIV in Non-Clinic Community-Based Settings

Funding overview

Long-acting injectable (LAI) antiretroviral therapy (ART) offers many potential advantages over daily oral treatment, such as:

• Improved convenience.
• Adherence.
• Treatment satisfaction.

There are barriers and challenges for the implementation of LAI-ART into current healthcare practice in logistics and equity. Some of these barriers may be overcome by using non-clinic sites, such as community pharmacies, to administer LAI-ART. This Notice of Funding Opportunity (NOFO) supports research on LAI-ART by implementing LAI-ART administration in non-clinic settings.

A multisite effectiveness-implementation research study will show how to improve the acceptability, availability, and uptake of LAI-ART. This study should compare the delivery of LAI-ART in non-clinic community settings with traditional HIV clinical treatment.

Implementation outcomes of interest include:

• Acceptability.
• Perceived barriers and facilitators.
• Feasibility.
• Sustainability.

Health outcomes of interest include:

• Missed visits.
• On-time receipt of injections.
• The HIV care continuum, including retention in care and viral load suppression.

Using innovative strategies of LAI-ART administration in non-clinic-based settings to decentralize its delivery will expand treatment opportunities. This NOFO funds qualitative and quantitative research to study real-world LAI-ART use in an era of multiple HIV treatment modalities.

Important dates

• Letter of Intent due date: Friday, January 27, 2023, 11:59 p.m. EST
• Application due date: Monday, February 27, 2023, 11:59 p.m. EST

Initiative priorities

The applied qualitative and quantitative research that results from this funding will strengthen adherence to ART. This research aligns with the:

• National HIV/AIDS Strategy (NHAS).
• Ending the HIV Epidemic in the U.S. (EHE) initiative's Treat pillar.

Activities and progress

This NOFO announcement is available at www.grants.gov. Select the Search Grants tab and enter RFA-PS-23-004 into the Basic Search Criteria, Opportunity Number box. Select the checkbox next to Archived.

To learn more about the CDC application process, visit the How to Apply for Grants webpage.

Recipients

Eligible locations

National

Support type

Cooperative agreements

Eligibility

• State governments
• County governments
• City or township governments
• Special district governments
• Independent school districts
• Public and state-controlled institutions of higher education
• Native American tribal governments (federally recognized)
• Public housing authorities/Indian housing authorities
• Native American tribal organizations (other than federally recognized tribal governments)
• Nonprofits that have a 501c3 status with the IRS (other than institutions of higher education)
• Nonprofits that do not have 501c3 status with the IRS (other than institutions of higher education)
• Private institutions of higher education
• For profit organizations other than small businesses
• Small businesses

The following types of higher education institutions are always encouraged to apply for CDC support as public or private institutions of higher education:

• Hispanic-serving institutions
• Historically Black Colleges and Universities (HBCUs)
• Tribally Controlled Colleges and Universities (TCCUs)
• Alaska Native and Native Hawaiian-serving institutions
• Nonprofits (other than institutions of higher education)

Governments/other

• Eligible agencies of the federal government
• U.S. territory or possession
• Faith-based or community-based organizations
• Regional organizations

Contacts

Program official/Scientific research

Jocelyn Patterson Mosley, MPH, MA
Extramural Research Program Office
404-639-6437
jpatterson@cdc.gov

Peer review

Gregory Anderson, MPH, MS
Extramural Research Program Office
404-718-8833
ganderson@cdc.gov

Financial/Grants management

Sharon Cassell
Office of Financial Resources/Office of Grant Services
770-488-2703
scassell@cdc.gov

Resources

Pre-application informational slides

PS-23-004 Pre-App NOFO Overview

Technical assistance mailbox

Potential applicants can send questions about the NOFO and application process to jpatterson@cdc.gov.