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Module 2: Toxicological Principles

Page 25 of 33

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Toxicokinetics: What the Body Does to the Toxic Agent

It is also important to consider toxicokinetics during an outbreak investigation. Understanding the toxicokinetic principles of a toxic agent helps determine which biological tests should be performed to confirm exposure to the toxic agent.

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There are four key concepts in toxicokinetics: absorption, distribution, metabolism, and elimination.

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If toxic agents are absorbed into the body, they are typically distributed through the blood to various organs.

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They are then eliminated through different ways such as urine or feces, or metabolized first and then eliminated.

Four key concepts in toxicokinetics: absorption, distribution, metabolism, and elimination.

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