Condition

Sub-condition

Combined pill, patch, ring

Progestin-only pill

Injection

Implant

LNG-IUD

Copper-IUD

I

C

I

C

I

C

I

C

I

C

I

C

Cirrhosis

a) Mild (compensated)

1

1

1

1

1

1

b) Severe† (decompensated)

4

3

3

3

3

1

DVT/PE

a) History of DVT/PE, not on anticoagulant therapy

i) higher risk for recurrent DVT/PE

4

2

2

2

2

1

ii) lower risk for recurrent DVT/PE

3

2

2

2

2

1

b) Acute DVT/PE

4

2

2

2

2

2

c) DVT/PE and established on anticoagulant therapy for at least 3 months

i) higher risk for recurrent DVT/PE

4*

2

2

2

2

2

ii) lower risk for recurrent DVT/PE

3*

2

2

2

2

2

d) Family history (first-degree relatives)

2

1

1

1

1

1

e) Major surgery

(i) with prolonged immobilization

4

2

2

2

2

1

(ii) without prolonged immobilization

2

1

1

1

1

1

f) Minor surgery without immobilization

1

1

1

1

1

1

Depressive disorders

1*

1*

1*

1*

1*

1*

Condition

Sub-condition

Combined pill, patch, ring

Progestin-only pill

Injection

Implant

LNG-IUD

Copper-IUD

I

C

I

C

I

C

I

C

I

C

I

C

Diabetes mellitus

a) History of gestational diabetes mellitus only

1

1

1

1

1

1

b) Non-vascular disease

(i) non-insulin dependent

2

2

2

2

2

1

(ii) insulin dependent†

2

2

2

2

2

1

c) Nephropathy/ retinopathy/ neuropathy†

3/4*

2

3

2

2

1

d) Other vascular disease or diabetes of >20 years' duration†

3/4*

2

3

2

2

1

Endometrial cancer†

1

1

1

1

4

2

4

2

Endometrial
hyperplasia

1

1

1

1

1

1

Endometriosis

1

1

1

1

1

2

Epilepsy†

(see also Drug Interactions)

1*

1*

1*

1*

1

1

Gallbladder disease

a) Symptomatic

(i) treated by cholecystectomy

2

2

2

2

2

1

(ii) medically treated

3

2

2

2

2

1

(iii) current

3

2

2

2

2

1

b) Asymptomatic

2

2

2

2

2

1

Gestational
trophoblastic disease

a) Decreasing or undetectable ß-hCG levels

1

1

1

1

3

3

b) Persistently elevated ß-hCG levels or malignant disease†

1

1

1

1

4

4

Headaches

a) Non-migrainous

1*

2*

1*

1*

1*

1*

1*

1*

1*

1*

1*

b) Migraine

i) without aura, age <35

2*

3*

1*

2*

2*

2*

2*

2*

2*

2*

1*

ii) without aura, age >35

3*

4*

1*

2*

2*

2*

2*

2*

2*

2*

1*

iii) with aura, any age

4*

4*

2*

3*

2*

3*

2*

3*

2*

3*

1*

Condition

Sub-condition

Combined pill, patch, ring

Progestin-only pill

Injection

Implant

LNG-IUD

Copper-IUD

I

C

I

C

I

C

I

C

I

C

I

C

History of bariatric surgery†

a) Restrictive procedures

1

1

1

1

1

1

b) Malabsorptive procedures

COCs: 3

3

1

1

1

1

P/R: 1

History of cholestasis

a) Pregnancy-related

2

1

1

1

1

1

b) Past COC-related

3

2

2

2

2

1

History of high blood pressure
during pregnancy

2

1

1

1

1

1

History of pelvic surgery

1

1

1

1

1

1

HIV

High risk

1

1

1*

1

2

2

2

2

HIV infected (see also Drug Interactions)†

1*

1*

1*

1*

2

2

2

2

AIDS (see also Drug Interactions) †

1*

1*

1*

1*

3

2*

3

2*

Clinically well on therapy

If on treatment, see Drug Interactions

2

2

2

2

Hyperlipidemias

2/3*

2*

2*

2*

2*

1*

Hypertension

a) Adequately controlled hypertension

3*

1*

2*

1*

1

1

b) Elevated blood pressure levels (properly taken measurements)

(i) systolic 140-159 or diastolic 90-99

3

1

2

1

1

1

(ii) systolic ≥160 or diastolic ≥100†

4

2

3

2

2

1

c) Vascular disease

4

2

3

2

2

1

Inflammatory bowel disease

(Ulcerative colitis, Crohn's disease)

2/3*

2

2

1

1

1

Ischemic heart
disease†

Current and
history of

4

2

3

3

2

3

2

3

1

Liver tumors

a) Benign

i) Focal nodular hyperplasia

2

2

2

2

2

1

ii) Hepatocellular adenoma†

4

3

3

3

3

1

b) Malignant†

4

3

3

3

3

1

Malaria

1

1

1

1

1

1

Condition

Sub-condition

Combined pill, patch, ring

Progestin-only pill

Injection

Implant

LNG-IUD

Copper-IUD

I

C

I

C

I

C

I

C

I

C

I

C

Multiple risk factors for arterial cardiovascular disease

(such as older age, smoking, diabetes and hypertension)

3/4*

2*

3*

2*

2

1

Obesity

a) >30 kg/m2 BMI

2

1

1

1

1

1

b) Menarche to <18 years and >30 kg/m2 BMI

2

1

2

1

1

1

Ovarian cancer†

1

1

1

1

1

1

Parity

a) Nulliparous

1

1

1

1

2

2

b) Parous

1

1

1

1

1

1

Past ectopic
pregnancy

1

2

1

1

1

1

Pelvic inflammatory disease

a) Past, (assuming no current risk factors of STIs)

(i) with subsequent pregnancy

1

1

1

1

1

1

1

1

(ii) without subsequent pregnancy

1

1

1

1

2

2

2

2

b) Current

1

1

1

1

4

2*

4

2*

Peripartum cardiomyopathy†

a) Normal or mildly impaired cardiac function

(i) <6 months

4

1

1

1

2

2

(ii) >6 months

3

1

1

1

2

2

b) Moderately or severely impaired cardiac function

4

2

2

2

2

2

Postabortion

a) First trimester

1*

1*

1*

1*

1*

1*

b) Second trimester

1*

1*

1*

1*

2

2

c) Immediately post-septic abortion

1*

1*

1*

1*

4

4

Postpartum
(see also Breastfeeding)

a) <21 days

4

1

1

1

b) 21 days to 42 days

(i) with other risk factors for VTE

3*

1

1

1

(ii) without other risk factors for VTE

2

1

1

1

c) >42 days

1

1

1

1

Condition

Sub-condition

Combined pill, patch, ring

Progestin-only pill

Injection

Implant

LNG-IUD

Copper-IUD

I

C

I

C

I

C

I

C

I

C

I

C

Postpartum (in breastfeeding or non-breastfeeding women, including post-cesarean section)

a) <10 minutes after delivery of the placenta

2

1

b) 10 minutes after delivery of the placenta to < 4 weeks

2

2

c) >4 weeks

1

1

d) Puerperal sepsis

4

4

Pregnancy

NA*

NA*

NA*

NA*

4*

4*

Rheumatoid
arthritis

a) On immunosuppressive therapy

2

1

2/3*

1

2

1

2

1

b) Not on immunosuppressive therapy

2

1

2

1

1

1

Schistosomiasis

a) Uncomplicated

1

1

1

1

1

1

b) Fibrosis of the liver†

1

1

1

1

1

1

Severe dysmenorrhea

1

1

1

1

1

2

STIs

a) Current purulent cervicitis or chlamydial infection or gonorrhea

1

1

1

1

4

2*

4

2*

b) Other STIs (excluding HIV and hepatitis)

1

1

1

1

2

2

2

2

c) Vaginitis (including trichomonas vaginalis and bacterial vaginosis)

1

1

1

1

2

2

2

2

d) Increased risk of STIs

1

1

1

1

2/3*

2

2/3*

2

Smoking

a) Age <35

2

1

1

1

1

1

b) Age >35, <15 cigarettes/day

3

1

1

1

1

1

c) Age >35, >15 cigarettes/day

4

1

1

1

1

1

Solid organ
transplantation†

a) Complicated

4

2

2

2

3

2

3

2

b) Uncomplicated

2*

2

2

2

2

2

Stroke†

History of cerebrovascular accident

4

2

3

3

2

3

2

1

Condition

Sub-condition

Combined pill, patch, ring

Progestin-only pill

Injection

Implant

LNG-IUD

Copper-IUD

I

C

I

C

I

C

I

C

I

C

I

C

Superficial venous thrombosis

a) Varicose veins

1

1

1

1

1

1

b) Superficial thrombophlebitis

2

1

1

1

1

1

Systemic lupus
erythematosus†

a) Positive (or unknown) antiphospholipid antibodies

4

3

3

3

3

3

1

1

b) Severe thrombocytopenia

2

2

3

2

2

2*

3*

2*

c) Immunosuppressive treatment

2

2

2

2

2

2

2

1

d) None of the above

2

2

2

2

2

2

1

1

Thrombogenic
mutations†

4*

2*

2*

2*

2*

1*

Thyroid disorders

Simple goiter/ hyperthyroid/hypothyroid

1

1

1

1

1

1

Tuberculosis†
(see also Drug
Interactions)

a) Non-pelvic

1*

1*

1*

1*

1

1

b) Pelvic

1*

1*

1*

1*

4

3

4

3

Unexplained vaginal bleeding

(suspicious for serious condition) before evaluation

2*

2*

3*

3*

4*

2*

4*

2*

Uterine fibroids

1

1

1

1

2

2

Valvular heart
disease

a) Uncomplicated

2

1

1

1

1

1

b) Complicated†

4

1

1

1

1

1

Vaginal bleeding
patterns

a) Irregular pattern without heavy bleeding

1

2

2

2

1

1

1

b) Heavy or prolonged bleeding

1*

2*

2*

2*

1*

2*

2*

Viral hepatitis

a) Acute or flare

3/4*

2

1

1

1

1

1

b) Carrier/Chronic

1

1

1

1

1

1

1

Condition

Sub-condition

Combined pill, patch, ring

Progestin-only pill

Injection

Implant

LNG-IUD

Copper-IUD

I

C

I

C

I

C

I

C

I

C

I

C

Drug Interactions

Antiretroviral therapy

a) Nucleoside reverse transcriptase inhibitors

1*

1

1

1

2/3*

2*

2/3*

2*

b) Non-nucleoside reverse transcriptase inhibitors

2*

2*

1

2*

2/3*

2*

2/3*

2*

c) Ritonavir-boosted protease inhibitors

3*

3*

1

2*

2/3*

2*

2/3*

2*

Anticonvulsant therapy

a) Certain anticonvulsants
(phenytoin, carbamazepine,
barbiturates, primidone,
topiramate, oxcarbazepine)

3*

3*

1

2*

1

1

b) Lamotrigine

3*

1

1

1

1

1

Antimicrobial therapy

a) Broad spectrum antibiotics

1

1

1

1

1

1

b) Antifungals

1

1

1

1

1

1

c) Antiparasitics

1

1

1

1

1

1

d) Rifampicin or rifabutin therapy

3*

3*

1

2*

1

1