At a glance
Number and rate* of newly reported cases† of chronic hepatitis B, by demographic characteristics — United States, 2022
| Characteristics | No. | Rate* |
|---|---|---|
| Total§ | 16,729 | 5.8 |
| Age (years) | ||
| 0–19 | 252 | 0.4 |
| 20–29 | 1,564 | 4.1 |
| 30–39 | 3,881 | 9.9 |
| 40–49 | 3,912 | 11.1 |
| 50–59 | 3,206 | 8.8 |
| ≥60 | 3,892 | 5.6 |
| Sex | ||
| Male | 9,348 | 6.6 |
| Female | 7,334 | 5.1 |
| Race/ethnicity | ||
| American Indian/Alaska Native, non-Hispanic | 73 | 3.2 |
| Asian/Pacific Islander, non-Hispanic | 3,651 | 20.1 |
| Black, non-Hispanic | 2,759 | 7.7 |
| White, non-Hispanic | 3,112 | 1.8 |
| Hispanic | 817 | 1.6 |
| Other | 1,098 | n/a |
| Urbanicity¶ | ||
| Urban | 15,513 | 6.2 |
| Rural | 1,188 | 3.1 |
| HHS region** | ||
| Region 1: Boston | 744 | 6.5 |
| Region 2: New York | 2,442 | 8.4 |
| Region 3: Philadelphia | 2,202 | 7.0 |
| Region 4: Atlanta | 4,341 | 7.1 |
| Region 5: Chicago | 1,746 | 3.3 |
| Region 6: Dallas | 1,302 | 12.1 |
| Region 7: Kansas City | 585 | 4.1 |
| Region 8: Denver | 363 | 2.9 |
| Region 9: San Francisco | 2,436 | 4.9 |
| Region 10: Seattle | 568 | 3.9 |
Source: CDC, National Notifiable Diseases Surveillance System.
* Rates per 100,000 population.
† Reported confirmed cases. For the case definition, see Chronic Hepatitis B.
§ Numbers reported in each category may not add up to the total number of reported cases in a year due to cases with missing data.
¶ Urban-rural region was categorized according to the 2013 National Center for Health Statistics (NCHS) urban-rural classification scheme for counties and county-equivalent entities. Large central metro, large fringe metro, medium metro, and small metro counties were grouped as urban. Micropolitan and noncore counties were grouped as rural.
** US Department of Health and Human Services regions were categorized according to the grouping of states and US territories assigned under each of the 10 Health and Human Services regional offices. For the purposes of this report, regions with US territories (Region 2 and Region 9) contain data from states only.
n/a: Not applicable. Rate cannot be calculated due to lack of corresponding denominator.
Summary
During 2022, the rate of newly reported cases of chronic hepatitis B was highest among persons aged 30–39 and 40–49 years and accounted for 47% of all chronic hepatitis B cases reported during 2022. The highest rate of newly reported chronic hepatitis B cases occurred among males, in urban areas (as defined by the National Center for Health Statistics), and among US Department of Health and Human Services Region 6 (Arkansas, Louisiana, New Mexico, Oklahoma, and Texas).
Although the rate of reported acute hepatitis B was the lowest among non-Hispanic Asian/Pacific Islander (A/PI) persons (Figure 2.6), the rate of newly reported chronic hepatitis B was highest among non-Hispanic A/PI persons (20.1 cases per 100,000 population) and was over 11 times the rate among non-Hispanic White persons (1.8 cases per 100,000 population). Variations of disease rates by race or ethnicity may reflect systemic cultural, behavioral, environmental, and social factors, including structural racism.
Race and ethnicity information was only available for 11,510 (69%) cases of newly reported chronic hepatitis B. Because the majority of prevalent chronic hepatitis B virus (HBV) infections in the United States are among persons who are non-US-born1, differences in the rates of newly reported chronic hepatitis B by race and ethnicity are likely influenced by country of birth. However, country of birth is not routinely collected in the National Notifiable Diseases Surveillance System (NNDSS).
- Bixler D, Barker L, Lewis K, Peretz L, Teshale E. Prevalence and awareness of Hepatitis B virus infection in the United States: January 2017–March 2020. Hepatol Commun. 2023 Mar 30; 7(4).