Large Drug-resistant Klebsiella pneumoniae Outbreak in an Acute Care Hospital — Indiana, United States, 2025
- Presentation Day/Time: Friday, April 24, 1:25 PM
- Presenter: Courtney Victor, PhD, MPH, EIS officer assigned to the National Center for Emerging and Zoonotic Infectious Diseases, Division of Healthcare Quality Promotion
The Issue
- Extended-spectrum beta-lactamase (ESBL)-producing Enterobacterales are antimicrobial resistant pathogens which cause difficult-to-treat infections. In April 2025, a hospital notified the Indiana Department of Health about an outbreak of ESBL-Klebsiella pneumoniae.
What We Did
- CDC assisted with identifying the sources of the outbreak and recommending control measures.
What We Found
- Our investigation linked the outbreak to gaps in infection prevention and control (IPC) practices and contamination of the healthcare environment.
What This Means
- This outbreak highlights the often-overlooked role of the environment in the spread of ESBL-producing pathogens.
