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Volume 30, Number 6—June 2024
Research

Chest Radiograph Screening for Detecting Subclinical Tuberculosis in Asymptomatic Household Contacts, Peru

Qi Tan1, Chuan-Chin Huang1, Mercedes C. Becerra, Roger Calderon, Carmen Contreras, Leonid Lecca, Judith Jimenez, Rosa Yataco, Jerome T. Galea, Jia-Yih Feng, Sheng-Wei Pan, Yen-Han Tseng, Jhong-Ru Huang, Zibiao Zhang, and Megan B. MurrayComments to Author 
Author affiliations: Harvard Medical School, Boston, Massachusetts, USA (Q. Tan, C.-C. Huang, M.C. Becerra, M.B. Murray); Brigham and Women’s Hospital, Boston (C.-C. Huang, M.C. Becerra, Z. Zhang, M.B. Murray); Partners In Health—Socios En Salud Sucursal Peru, Lima, Peru (R. Calderon, C. Contreras, L. Lecca, J. Jimenez, R. Yataco); University of South Florida, Tampa, Florida, USA (J.T. Galea); Taipei Veterans General Hospital, Taipei, Taiwan (J.-Y. Feng, S.-W. Pan, Y.-H. Tseng, J.-R. Huang); National Yang Ming Chiao Tung University, Taipei (J.-Y. Feng, S.-W. Pan, Y.-H. Tseng, J.-R. Huang); Harvard T.H. Chan School of Public Health, Boston (M.B. Murray)

Main Article

Table 4

Chest radiograph and symptom screening results and their association with risk for subsequent TB in adults with no known TB history*

Result† No. (%) incident TB cases Univariate analysis
 Multivariate analysis‡
Hazard ratio (95% CI), n = 1,440, event = 37 p value Hazard ratio (95% CI), n = 1,347, event = 34 p value
CXR–SX– 14 (1) Referent Referent
CXR–SX+ 4 (3) 1.45 (0.48–4.39) 0.51 1.64 (0.53–5.11) 0.39
CXR+SX– 15 (21) 19.46 (9.39–40.33) <0.001 23.11 (10.35–51.57) <0.001
CXR+SX+ 4 (40) 38.53 (12.67–117.18) <0.001 34.24 (9.65–121.54) <0.001

*In both analyses, n indicates number of analyzed participants and event indicates number of participants in whom incident TB developed. CXR–, unremarkable chest radiograph, CXR+, abnormal chest radiograph; SX–, no symptoms; SX+, symptoms; TB, tuberculosis. †Symptoms were defined as any of the following: cough>14 d, cough with blood or phlegm, fever, shortness of breath, night sweats. Abnormal chest radiograph was defined as a radiograph with any intra-thorax abnormalities compatible with TB. Abnormal CXR was defined as a CXR with any intra-thorax abnormalities compatible with TB. ‡Adjusted for age, sex, alcohol use, tobacco use, diabetes, hypertension, cardiovascular disease, kidney disease, asthma, TB history and BMI. HIV-positive persons (n = 3) were excluded.

Main Article

1These authors contributed equally to this article.

Page created: April 19, 2024
Page updated: May 22, 2024
Page reviewed: May 22, 2024
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