Objective
- The objective of this study is:
- To determine the accuracy of salivary osmolality measurements taken with a new hand-held osmometer compared to a standard laboratory osmometer using freeze point depression technology during states of acute, mild dehydration (3%, 5%),
- To evaluate any correlation between salivary osmolality by both pieces of equipment with plasma osmolality measured by the standard laboratory osmometer
- To examine the effect of various subject characteristics (i.e., age, gender, fitness, smoking) upon readings from the hand-held salivary osmometer.
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- ASTM F 2668-07 Standard Practice for Determining the Physiological Responses of the Wearer to Protective Clothing Ensembles
- ISO 7933 Hot Environments – Analytical Determination and Interpretation of Thermal Stress Using Calculation of Required Sweat Rates
- Technical Support Working Group (Washington, DC)
- Cantimer, Inc. (Menlo Park, CA)
- Woolongong University (Australia)
- Firefighters
- Military Personnel
- Agricultural workers
- Roofers
- Lifeguards
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Project Scope
- This study may require ~60 subjects to complete all phases. If the hand-held osmometer is found to be accurate, this could allow for detection of early dehydration in populations at risk (e.g., firefighters, military personnel, roofers, agricultural workers, etc.).
Milestones
- Q1 Send draft protocol to TSWG for approval (completed, December, 2008) and Send draft dehydration protocol out for peer-review (completed, January 2009)
- Q2 Submit draft protocol to HSRB for approval and Obtain HSRB approval and begin subject recruitment (Spring, 2009)
- Q3 Recruit an initial 30 subjects, complete first phase (medical screening, GXT) and second phase (dehydration induction and laboratory measurements) of dehydration study (Fall of 2010)
- Q4 Complete third phase of dehydration study (dental appliance use, SCBA use)
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Outputs
- Final Report to the client (TSWG)
- Publications in peer-reviewed journals
- Guidance documents to key stakeholders on thermal stress monitoring
Outcomes
- Use of data in the development and modification of standards (ASTM, ISO) related to heat stress and hydration status.
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