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Ethylamine
May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS number: 75–04–7
NIOSH REL: 10 ppm (18 mg/m3) TWA
Current OSHA PEL: 10 ppm (18 mg/m3) TWA
1989 OSHA PEL: Same as current PEL
1993-1994 ACGIH TLV: 5 ppm (9.2 mg/m3) TWA, 15 ppm (27.6 mg/m3) STEL
Description of Substance: Colorless gas or water-white liquid (below 62 F) with an ammonia-like odor.
LEL:. . 3.5% (10% LEL, 3,500 ppm)
Original (SCP) IDLH: 4,000 ppm
Basis for original (SCP) IDLH: The chosen IDLH is based on the UCC [1958] report that a 4-hour exposure to 4,000 ppm killed 1 of 6 rats.
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA
Lethal concentration data:
| Species | Reference | LC50(ppm) | LCLo(ppm) | Time | Adjusted 0.5-hrLC (CF) | Derivedvalue |
|---|---|---|---|---|---|---|
| RatMammal
Rat |
Hine et al. 1960Kulagina 1975
UCC 1958 |
—–1,230
—– |
3,000—–
4,000 |
4 hr?
4 hr |
6,000 ppm (2.0)?
8,000 ppm (2.0) |
600 ppm?
800 ppm |
Lethal dose data:
| Species | Reference | Route | LD50(mg/kg) | LDLo(mg/kg) | Adjusted LD | Derived value |
|---|---|---|---|---|---|---|
| Rat | UCC 1958 | oral | 400 | —– | 1,497 ppm | 150 ppm |
Human data: None relevant for use in determining the revised IDLH.
| Revised IDLH: 600 ppmBasis for revised IDLH: The revised IDLH for ethylamine is 600 ppm based on acute inhalation toxicity data in animals [Hine et al. 1960; UCC 1958]. |
REFERENCES:
1. Hine CH, Kodama JK, Guzman RJ, Loquvam GS [1960]. The toxicity of allylamines. Arch Environ Health 1:343-352.
2. Kulagina NK [1975]. Dependence of biological activity of aliphatic hydrocarbons on their chemical structure and physical-chemical properties. Toksikol Nov Prom Khim Vesh 14:80-90 (in Russian).
3. Smyth HF Jr, Carpenter CP, Weil CS, Pozzani UC [1954]. Range-finding toxicity data: list V. AMA Arch Ind Hyg Occup Med 10:61-68.
4. UCC [1958]. Toxicology studies: ethyl amine. New York, NY: Union Carbide Corporation.